Paleoneurology: Neurodegenerative diseases are age-related diseases of specific brain regions recently developed by homo sapiens

Ghika, Joseph-André

doi:10.1016/j.mehy.2008.05.034

Cited by 26 publications

(19 citation statements)

References 243 publications

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“…[68][69][70] Over the 5-6 million years of hominid evolution, the acquisition of enormously big brains with advanced cognitive ability, complex vocal organs, bipedalism, and opposable thumbs has induced major neocortical changes with new cortical areas and increased interconnections. 10,71,72 As described earlier, the corpus callosum may have been an important ''enabler'' in this complex evolution.…”

Section: Other Evolutionary Considerationsmentioning

confidence: 99%

Amyotrophic lateral sclerosis—Evolutionary and other perspectives

Eisen¹

2009

Muscle and Nerve

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In this study some particular and puzzling aspects of amyotrophic lateral sclerosis (ALS) are discussed, with an emphasis on the role of neocortical evolution. Other issues explored include the nature of the clinical deficit in ALS; anatomical and evolutionary aspects of the neocortex, motor cortex, and corpus callosum; and some discussion as to when ALS begins. In common with other neurodegenerative diseases, ALS may result from dysfunctional neocortical circuitry. It is suggested that the disease starts some years prior to clinical onset, possibly in adolescence, or even earlier, when there is marked alteration of anatomy, physiology, and biochemistry of the neocortex. The failure of naturally occurring animal models of ALS or models that truly replicate the human disease may reflect the unique, continued, and increased neocortical evolution of modern humans. Muscle Nerve 40: 297-304, 2009.

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Section: Other Evolutionary Considerationsmentioning

confidence: 99%

Amyotrophic lateral sclerosis—Evolutionary and other perspectives

Eisen¹

2009

Muscle and Nerve

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“…Actually, these cases had been known in Turkey for many years and had attracted the curiosity of the public media. It was first reported scientifically to the members of the Turkish Academy of Sciences in Ankara and Istanbul, and published under the proposed name, "Uner Tan Syndrome" (Tan, 2005a-d), which sparked world-wide interest (Garber, 2008;Ghika, 2008;Akpinar, 2009;Le Fanu, 2009;Held, 2009). Two interesting and rather comprehensive articles by Greg Downey (2010a, b), Senior Lecturer in Anthropology at Macquarie University in Sydney, were published about UTS in the recently introduced PLoS blog Neuroanthropology.…”

Section: "As We Rose Out Of the Next Valley A Donkey And A Figure On mentioning

confidence: 99%

“…Under Darwinian diseases, Rapoport (1988) first considered Alzheimer's disease as a "phylogenic regression" under the main heading "phylogenic diseases," "that compares brain aging involution to the reversed phenomenon of Darwinian evolution" (Ghika, 2008). Similarly, many neurodegenerative diseases such as Parkinson's disease (Vernier et al, 2004), gait disorders (Tan, 2005d;Tan, 2006a, b;Tan, 2010a), schizophrenia (Brüne, 2004;Burns, J.K. (2004), and the highest level gait disorders including Uner Tan syndrome, with its simianlike gait and posture or apraxia, i.e., the re-emergence of old automatism of pre-human gait, may also be considered under these phylogenic diseases (Ghika, 2008).…”

Section: Darwinian Medicinementioning

confidence: 99%

“…Similarly, many neurodegenerative diseases such as Parkinson's disease (Vernier et al, 2004), gait disorders (Tan, 2005d;Tan, 2006a, b;Tan, 2010a), schizophrenia (Brüne, 2004;Burns, J.K. (2004), and the highest level gait disorders including Uner Tan syndrome, with its simianlike gait and posture or apraxia, i.e., the re-emergence of old automatism of pre-human gait, may also be considered under these phylogenic diseases (Ghika, 2008). In this context, the paleoneurologic standpoint recently introduced to clinical neurology may help us to more deeply understand the pathogenesis of the neural disorders, provided that they are reconsidered under evolutionary principles.…”

Section: Darwinian Medicinementioning

confidence: 99%

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Üner Tan Syndrome: Review and Emergence of Human Quadrupedalism in Self-Organization, Attractors and Evolutionary Perspectives

Tan¹,

Tamam²,

Karaca³

et al. 2012

Latest Findings in Intellectual and Developmental Disabilities Research

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“…The clinical and radiological characteristics of these cases are presented in Table 1. The syndrome has sparked a world-wide interest: see, for instance, Garber (2008), Ghika (2008), Caglayan (2008, Thesis), Akpinar (2009), Le Fanu (2009), Held (2009, Kolb (2009, Thesis), Kutty (2010), Bornstein (2010), Pribut (2010), Downey (2010a, b), MacLellan et al (2011), Arif et al (2011).…”

mentioning

confidence: 99%