This is a synthesis of major middle and late Cenozoic oceanographic and climatic events revealed in a diverse suite of studies by Leg 90 investigators and involving analyses of oxygen and carbon isotopes, sediment character, and accumulation rates and microfossils. The benthic δ 18 θ record in Leg 90 sites exhibits a number of large changes that reflect the sequential development of polar glaciation and cooling of bottom waters beginning in the latest Eocene-earliest Oligocene. Major climatic cooling events in the Leg 90 sequences include the Terminal Eocene Event (37 Ma); middle Oligocene cooling events clustered close to 31 Ma; the Middle Miocene Event (16.5-13.5 Ma); further temporary cooling events during the late middle Miocene (12.5 to 11.5 Ma) and the earliest late Miocene (11-9 Ma); the Terminal Miocene Event (-6.2-5.0 Ma), the Middle Pliocene Cooling Event at 3.4 Ma; the Late Pliocene Event at 2.6-2.4 Ma; and amplification of glacial-interglacial oscillations during the Quaternary at 0.9 Ma (Jaramillo Paleomagnetic Subchron). The climax of Neogene warmth occurred during the early Miocene, especially between 19.5 and 16.5 Ma. The sequences record the development during the Cenozoic of latitudinal and vertical thermal gradients in the southwest Pacific region. Major, permanent increases in the vertical temperature gradients occurred in association with the Middle Miocene Event (16.5-13.5 Ma), the Middle Pliocene Cooling Event (3.4 Ma) and the Late Pliocene Event (2.6-2.4 Ma). Deep-sea benthic foraminiferal assemblages underwent important changes near the Eocene/Oligocene boundary and during the earliest Middle Miocene, the latest Miocene, and the late Pliocene and Quaternary. Late Neogene benthic foraminiferal changes are, in part, related to changes in the organic flux rates that accompanied changes in biogenic sedimentation rates and inferred surface-water productivity. Changes in clay mineralogy, wind-blown terrigenous sediments, and opal phytoliths in the Lord Howe Rise Sites record a general expansion of Australian deserts. Important steps in aridification occurred during the Middle Miocene Event; the Terminal Miocene Event (~5 Ma), and the Middle Pliocene Cooling Event (-3.4 Ma).