Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence

Kawamoto, Sayuri; Tanaka, Shimako; Miura, Mikihiko; Kashiwagura, Yasuharu; Kamiya, Chiaki; Hakamata, Akio; Odagiri, Keiichi; Inui, Naoki; Watanabe, Hiroshi; Namiki, Noriyuki; Uchida, Shinya

doi:10.1248/cpb.c23-00102

Cited by 2 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Penelitian lain menyebutkan, bahwa tingkat kepatuhan minum obat dipengaruhi juga oleh formulasi obat itu sendiri (Kawamoto et al, 2023). Kepatuhan minum obat lebih tinggi pada pasien yang menggunakan sediaan obat dalam bentuk kapsul dibandingkan dengan tablet (Srivastava et al, 2019).…”

Section: Pembahasanunclassified

Sikap dan Perilaku Swamedikasi Dismenore Primer pada Mahasiswi Farmasi Universitas Ngudi Waluyo

Haswan,

Pujiastuti,

Pratiwi

2024

IJPNP

View full text Add to dashboard Cite

Women experience pain that varies in intensity for each individual. Menstrual pain can be treated using pharmacological and non-pharmacological therapy. The use of therapy for dysmenorrhea can improve the quality of life of sufferers. The Pharmacy Study Program at Ngudi Waluyo University is dominated by female students where menstrual pain will be an obstacle that affects their academic and daily activities. The aim of this study was to determine the attitudes and behavior of students from the Pharmacy Study Program at Ngudi Waluyo University when experiencing primary dysmenorrhea and to assess the strength of the correlation between the intensity of dysmenorrhea pain and therapy. The method used in this research is descriptive analysis with simple random sampling data collection techniques. Data was analyzed using the SPSS 25 statistical application. Based on the data obtained, 27.11% of respondents used therapy, and 72.89% of respondents did not use therapy. Reducing the pain intensity of primary dysmenorrhea has a correlation of 0.520 (moderate) with the use of therapy. Based on statistical tests on academic activities (sig. 0.006) and daily activities (sig. 0.000) which shows that there is an influence of primary dysmenorrhea on the academic and daily activities of respondents, but it has a weak correlation, namely 0.212 and 0.306 respectively. The use of therapy can reduce the intensity of pain in primary dysmenorrhea, however, many do not use therapy when experiencing primary dysmenorrhea and primary dysmenorrhea affects the respondents' academic and daily activities. ABSTRAK Perempuan mengalami nyeri haid dengan intensitas yang berbeda pada setiap individu. Nyeri haid dapat diatasi menggunakan terapi farmakologi maupun non farmakologi. Penggunaan terapi pada dismenore dapat meningkatkan kualitas hidup penderita. Prodi Farmasi Universitas Ngudi Waluyo didominasi oleh mahasiswi dimana nyeri haid akan menjadi kendala yang mempengaruhi aktivitas akademik maupun kesehariannya. Tujuan penelitian ini adalah untuk mengetahui sikap dan perilaku mahasiswi Prodi Farmasi Universitas Ngudi Waluyo ketika mengalami dismenore primer dan menilai kekuatan korelasi intensitas nyeri dismenore terhadap terapi. Metode yang digunakan pada penelitian ini adalah analisis deskriptif dengan teknik pengambilan data simple random sampling. Data dianalisis menggunakan aplikasi statistik SPSS 25. Berdasarkan data yang diperoleh, sebanyak 27,11% responden menggunakan terapi, dan 72,89% responden tidak menggunakan terapi. Penurunan intensitas nyeri dismenore primer mempunyai korelasi 0,520 (moderate) dengan penggunaan terapi. Berdasarkan uji statistik pada aktivitas akademik (sig. 0,006) dan aktivitas keseharian (sig. 0,000) yang menunjukkan terdapat pengaruh dismenore primer terhadap kegiatan akademik dan keseharian respoden, namun mempunyai korelasi yang lemah, yaitu masing-masing 0,212 dan 0,306. Penggunaan terapi dapat menurunkan intensitas nyeri pada dismenore primer, akan tetapi banyak yang tidak menggunakan terapi ketika mengalami dismenore primer dan dismenore primer mempengaruhi kegiatan akademik dan keseharian responden.

show abstract

Section: Pembahasanunclassified

Sikap dan Perilaku Swamedikasi Dismenore Primer pada Mahasiswi Farmasi Universitas Ngudi Waluyo

Haswan,

Pujiastuti,

Pratiwi

2024

IJPNP

View full text Add to dashboard Cite

show abstract

Improved Palatability of Gummy Drugs of Epinastine Hydrochloride Using Organoleptic Taste-Masking Methods

Tanaka,

Kawamoto,

Kashiwagura

et al. 2023

BPB Reports

Self Cite

View full text Add to dashboard Cite

Gummy drugs are dried jelly formulations prepared by adding a gelling agent to saccharides, which are then cooled and solidified. Epinastine hydrochloride (Epi) is commonly used to treat allergic diseases as a prescription and over-the-counter drug. However, the extremely bitter taste of Epi would affect its acceptability among patients. In this study, we aimed to improve the palatability of a gummy drug containing Epi (Epi-G) via organoleptic masking. Epi-G (10 mg of Epi/3.5 g of gummy drug) with two different organoleptic masking formulations, namely aspartame, cocoa powder, and chocolate flavoring (C-Epi-G) or aspartame, L-menthol, and lemon flavoring (L-Epi-G). The gustatory sensation test included six healthy adult volunteers (23.3 ± 1.8 years). We used a visual analogue scale (VAS) to evaluate bitterness, sweetness, and the overall palatability of each Epi-G formulation during chewing and after spitting out the drugs. In the gustatory sensation test, the VAS scores for bitterness and sweetness were decreased and increased for C-Epi-G and L-Epi-G, respectively, compared with the values for Epi-G without organoleptic masking. The VAS scores for overall palatability during chewing for C-Epi-G and L-Epi-G were significantly increased by 2.3-and 2.0-fold, respectively, versus the value for Epi-G. The score after spitting out C-Epi-G remained higher than that of Epi-G. These data illustrated that Epi-G with organoleptic masking had good palatability, which could improve patient adherence to treatment. The gummy drugs could represent an alternative dosing formulation for pediatric and geriatric patients by allowing them to take the drugs more easily than other oral formulations.

show abstract

Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence

Cited by 2 publications

References 20 publications

Sikap dan Perilaku Swamedikasi Dismenore Primer pada Mahasiswi Farmasi Universitas Ngudi Waluyo

Sikap dan Perilaku Swamedikasi Dismenore Primer pada Mahasiswi Farmasi Universitas Ngudi Waluyo

Improved Palatability of Gummy Drugs of Epinastine Hydrochloride Using Organoleptic Taste-Masking Methods

Contact Info

Product

Resources

About