Palatability, food intake, and obesity in normal and hyperphagic rats.

Corbit, John D.; Stellar, Eliot

doi:10.1037/h0039787

Cited by 242 publications

(98 citation statements)

References 11 publications

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“…It has been demonstrated that various sensory dimensions affect the degree of hyperphagic weight gain in VMH-Iesioned rats. Studies with nonnutritive greasy additives suggest that VMH-lesioned animals overrespond to the taste and textural aspects of the highfat diet rather than to its postingestional effects (Corbit & Stellar, 1964;Strubbe & Steffens, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…Palatibility of the diet is an important variable, since rats with damage to the VMH are "finicky eaters," consuming large amounts of a highly palatable diet while eating less than controls on diets that are unpalatable (Corbit & Stellar, 1964;Panksepp, 1971;Teitelbaum, 1955). We therefore extended our previous investigation by investigating whether or not CCK would be effective as an appetite suppressant for VMH-Iesioned rats consuming a more palatable diet.…”

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Appetite suppression caused by CCK is diet specific in VMH-lesioned rats

1979

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Section: Discussionmentioning

confidence: 99%

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Appetite suppression caused by CCK is diet specific in VMH-lesioned rats

1979

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“…Such animals are hyperreactive to touch (Singh, 1969), overresponsive to oro sensory characteristics of food (Beatty & Schwartzbaum, 1967;Corbit & Stellar, 1964;Singh & Meyer, 1968), and possibly hyperphagic (Singh & Meyer, 1968). Both septal and VMH rats display reduced spontaneous alternation activity in aT-maze (Singh, 1973a), decreased spontaneous behavior (Schwartzbaum & Gay, 1966;Teitelbaum, 1961), and poor performance on passive avoidance tasks (Hamilton, Kelsey, & Grossman, 1970;Margules & Stein, 1969; Singh, 1973a).…”

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Comparison of septal and ventromedial hypothalamic lesion effects on discrete trial DRL behavior

Flynn

Mitchell

1980

Psychobiology

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The performance of rats with ventromedial hypothalamic (VMH) or septal lesions was compared with that of normal subjects on a discrete trial DRL task. Animals were pretrained at 85% of their ad-lib body weights and postoperatively tested at this level of deprivation and at greater and lesser deprivation levels. Septal rats emitted significantly more nonreinforced responses and had shorter response latencies than did control and VMH rats while tested at the different deprivation levels. VMH lesioned rats performed as well as controls_ Septal performance was not affected by deprivation level. Both VMH and control subjects obtained the greatest number of reinforcements while tested at the greater deprivation level. In spite of the large number of similarities between VMH and septal rats, VMH rats, unlike septal rats, used internal cues as well as normal rats did to perform proficiently on this task.Rats with lesions of the ventromedial hypothalamus (VMH) and septum display a number of behavioral similarities. Such animals are hyperreactive to touch (Singh, 1969), overresponsive to oro sensory characteristics of food (Beatty & Schwartzbaum, 1967;Corbit & Stellar, 1964;Singh & Meyer, 1968), and possibly hyperphagic (Singh & Meyer, 1968). Both septal and VMH rats display reduced spontaneous alternation activity in aT-maze (Singh, 1973a), decreased spontaneous behavior (Schwartzbaum & Gay, 1966;Teitelbaum, 1961), and poor performance on passive avoidance tasks (Hamilton, Kelsey, & Grossman, 1970;Margules & Stein, 1969; Singh, 1973a). Furthermore, Kaada (1951) observed that electrical stimulation of either the septum or VMH depressed respiration and blood pressure and would inhibit spinal reflexes and movement elicited by cortical stimulation.The behavioral similarities observed following septal and VMH lesions or stimulation suggest that these two areas are part of an inhibitory somatomotor system (Kaada, 1951(Kaada, , 1960. Van Hoesen, MacDougall, Wilson, and Mitchell (1971) have shown that septal rats perform poorly on a discrete trial DRL task (DT-DRL). During this task, the insertion of the lever into the operant chamber signals the start of the delay on DRL. The poor septal performance on this task was interpreted to indicate that septals are unable to organize collateral behaviors to bridge the delay period or to use response-produced cues.This research was supported in part by NIH Biomedical Research Support Grant RR07036. Requests for reprints should be addressed to James C. Mitchell, Department of Psychology, Kansas State University, Manhattan, Kansas 66506.In light of Kaada's hypothesis and the behavioral similarities of VMH and septal rats, it was of interest to see ifVMH rats also perform similarly on a DT-DRL task.Our initial observations showed no differences in performance between normal and VMH subjects, while septals performed less proficiently. In order to increase the likelihood of VMH-normal performance differences on this task, levels of food deprivation were subsequently manipulated. METHOD Subj...

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“…It should be noted that rats on NN substance diet drink considerable amounts of water-a factor which may have made weight measurements in the present study somewhat high. The body weight gain under N substance diet in the present study would be expected since the caloric value of this substance (4.00 cal/g) exceeds the caloric value of laboratory Purina Chow (3.61 cal/g; Corbit & Stellar, 1964 45 m1 "Pepsi-Cola" (non-carbonated fountain syrup) 55 m1 tap water Order of mixture. Add alI of the dry ingredients together and mix with an electric mixer.…”

Section: First Applicationsmentioning

confidence: 99%