Palaeomicrobiology of Tuberculosis

Donoghue, Helen D.

doi:10.1007/978-3-540-75855-6_6

Cited by 9 publications

(17 citation statements)

References 101 publications

(90 reference statements)

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“…These early studies confirmed TB in Byzantine Turkey, pre-European contact Borneo, and a pre-Columbian Andean mummy (1000 BP). They were quickly followed by reports of MTBC aDNA in ancient Egypt, China, America, and Europe, summarized in a series of reviews [18,[25][26][27][28][29].…”

Section: Early Biomolecular Studiesmentioning

confidence: 98%

“…The early development of this field in archaeology and palaeontology had a strong influence on the initial criteria that emerged regarding the precautions required for the production of verifiable data based on aDNA [16,17]. These have since been modified [18] to take account of our increased understanding of the sources of contamination [19] and the stability of Mycobacterium tuberculosis complex (MTBC) aDNA [20] as compared with other biomolecules [21,22].…”

Section: Early Biomolecular Studiesmentioning

confidence: 99%

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Insights gained from palaeomicrobiology into ancient and modern tuberculosis

Donoghue

2011

Clinical Microbiology and Infection

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The direct detection of ancient Mycobacterium tuberculosis molecular biomarkers has profoundly changed our understanding of the disease in ancient and historical times. Initially, diagnosis was based on visual changes to skeletal human remains, supplemented by radiological examination. The introduction of biomolecular methods has enabled the specific identification of tuberculosis in human tissues, and has expanded our knowledge of the palaeopathological changes associated with the disease. We now realize that the incidence of past tuberculosis was greater than previously estimated, as M. tuberculosis biomarkers can be found in calcified and non-calcified tissues with non-specific or no visible pathological changes. Modern concepts of the origin and evolution of M. tuberculosis are informed by the detection of lineages of known location and date.

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Section: Early Biomolecular Studiesmentioning

confidence: 98%

Section: Early Biomolecular Studiesmentioning

confidence: 99%

Insights gained from palaeomicrobiology into ancient and modern tuberculosis

Donoghue

2011

Clinical Microbiology and Infection

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“…For millennia, tuberculosis (TB) remains a public health problem [1][2][3] . Between 2000 and 2015, at the global level, 49 million patients survived through strategies that sought greater performance in TB diagnosis and treatment in high-burden countries.…”

mentioning

confidence: 99%

Tuberculosis: renewed challenge in Brazil

Kritski

Andrade

Galliez

et al. 2018

Rev. Soc. Bras. Med. Trop.

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“…Based on molecular analysis, the prevalence of TB was skeletal material dated to different centuries, and spinal TB was diagnosed in four cases 21 (Donoghue et al, 2008;Éry et al, 2008a, 2008b. Another case of spinal TB was described in 22 material from Zalavár-Vár (Acsádi et al, 1962).…”

mentioning

confidence: 99%

New skeletal tuberculosis cases in past populations from Western Hungary (Transdanubia)

Évinger

Bernert

Fóthi

et al. 2011

HOMO

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1The distribution, antiquity and epidemiology of tuberculosis (TB) have previously been studied in 2 osteoarchaeological material in the eastern part of Hungary, mainly on the Great Plain. The 3 purpose of this study is to map the occurrence of skeletal TB in different centuries in the Western 4 part of Hungary, Transdanubia, and to present new cases we have found. Paleopathological 5 analysis was carried out using gross observation supported by radiographic and molecular 6 methods. A large human osteoarchaeological sample (n=5684) from Transdanubian 7 archaeological sites ranging from the 2nd to the 18th centuries served as a source of material. 8Spinal TB was observed in seven individuals (in three specimens with Pott's disease two of 9 which also had cold abscess) and hip TB was assumed in one case. The results of DNA for 10Mycobacterium tuberculosis were positive in seven of the eight cases identified by 11 paleopathology, and negative in the assumed case of hip TB. However, the molecular results are 12 consistent with highly fragmented DNA, which limited further analysis. Based on the present 13 study and previously published cases, osteotuberculosis was found in Transdanubia mainly 14 during the 9th-13th centuries. However, there are no signs of TB in many other 9th-13th 15 centuries, even in those that lie geographically close to those where osteotuberculous cases were 16found. This may be due to a true absence of TB caused by the different living conditions, way of 17 life, or origin of these populations An alternative explanation is that TB was present in some 18 individuals with no typical paleopathology, but that death occurred before skeletal morphological 19 features could develop. 20 21 3

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Palaeomicrobiology of Tuberculosis

Cited by 9 publications

References 101 publications

Insights gained from palaeomicrobiology into ancient and modern tuberculosis

Insights gained from palaeomicrobiology into ancient and modern tuberculosis

Tuberculosis: renewed challenge in Brazil

New skeletal tuberculosis cases in past populations from Western Hungary (Transdanubia)

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