Palaeolithic Diet in Diabesity and Endocrinopathies – A Vegan’s Perspective

Gupta, Lovely; Khandelwal, Deepak; Lal, Priti Rishi; Kalra, Sanjay; Dutta, Deep

doi:10.17925/ee.2019.15.2.77

Cited by 13 publications

(12 citation statements)

References 39 publications

(47 reference statements)

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“…Nevertheless, it seems that the diet, but also the adherence of each patient to the regimen, remains an essential point to successfully manage loss weight and glycaemic profiles of patients with diabesity. It is important to understand that is not all about the nutrients but also the origin and the processing of foods which may be considered when associating diet with health and disease [ 62 ].…”

Section: Clinical Management Of Diabesitymentioning

confidence: 99%

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

et al. 2020

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Obesity is a condition of rising prevalence worldwide, with important socioeconomic implications, being considered as a growing public health concern. Frequently, obesity brings other complications in addition to itself—like Type 2 Diabetes Mellitus (T2DM)—sharing origin, risk factors and pathophysiological mechanisms. In this context, some authors have decided to include both conditions as a unique entity known as “diabesity”. In fact, understanding diabesity as a single disease is possible to maximise the benefits from therapies received in these patients. Gut microbiota plays a key role in individual’s health, and their alterations, either in its composition or derived products are related to a wide range of metabolic disorders like T2DM and obesity. The present work aims to collect the different changes reported in gut microbiota in patients with T2DM associated with obesity and their possible role in the onset, development, and establishment of the disease. Moreover, current research lines to modulate gut microbiota and the potential clinical translation derived from the knowledge of this system will also be reviewed, which may provide support for a better clinical management of such a complex condition.

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Section: Clinical Management Of Diabesitymentioning

confidence: 99%

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

et al. 2020

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“…Plant-based or vegan versions of a Paleolithic diet have been proposed [236]. The previously mentioned findings supporting vegan, vegetarian, low fat and lower animal product diets would suggest that these alternative versions of a Paleolithic diet are worth studying.…”

Section: Diet the Intestinal Microbiota And The Phm Hypothesismentioning

confidence: 99%

The Post-hunter-gatherer Era Microbes Hypothesis for Chronic Inflammatory Diseases

Waterhouse¹

2020

Preprint

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This article proposes an extension of the hygiene hypothesis to explain chronic inflammatory diseases (CIDs) and their increase with westernization. Instead of emphasizing microbes that are missing/reduced due to westernization, a hypothesis is proposed that emphasizes the importance of microbes that are relatively novel. Environmental microbes encountered in association with a pre-agricultural lifestyle would presumably be the most coevolved with the human immune system and thus less likely to promote chronic disease. Post-hunter-gatherer era microbes (PHMs) are microbes that are encountered more frequently and/or at higher levels since humans ceased to live as nomadic hunter-gatherers. It is hypothesized that some PHMs, particularly those increasing with westernization, colonize human tissues and dysregulate/suppress the immune system. This hypothesized colonization of PHMs could cause allergy/hypersensitivity reactions leading to physiological stress, attacks on self-tissue, hypersensitivity reactions to similar cross-reacting environmental microbes and other allergens/antigens, greater vulnerability to diverse infections (e.g., COVID-19) and CIDs. Low-level colonization with diverse PHMs could explain high levels of comorbidities among CIDs, allergic responses to self-tissue (auto allergy), allergies to varied microbial taxa and allergen-initiated stress effects. Allergic reactions and the stress they cause might be adaptive by promoting expulsion and avoidance of potentially dangerous microbes. This is consistent with the observation that selective IgE deficiency leads to increased levels of diseases such as asthma, chronic rhinosinusitis, otitis media and autoimmune disease. PHMs that could be related to CIDs include microbes in tobacco smoke, increased Candida albicans and Aspergillus fumigatus that occurs in some situations, and increased exposure to Pseudomonas fluorescens and Yersinia spp. Additionally, fungi that tolerate multiple extreme environments have been found to be more likely to be opportunistic pathogens. This might suggest that microbes associated with human-created novel and extreme environments (e.g., antibiotics, xenobiotics) would have an increased ability to colonize and persist in humans. The PHM hypothesis could help explain contradictory findings on diet, why many chronic inflammatory diseases resemble chronic infections and why stress and xenobiotics are associated with CID incidence and exacerbations. Four foundations and 11 related hypotheses are discussed. Examples discussed include sarcoidosis, inflammatory bowel disease, asthma, long-term COVID-19 and Kawasaki disease.

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“…The paleolithic (Paleo) diet is an increasingly popular way of eating that attempts to mirror what our ancestors may have consumed between 10,000 and 2.5 million years ago. 100 It is similar to the Mediterranean diet but excludes grains, dairy, legumes, and nightshade vegetables. It also calls for elimination of highly processed sugars and oils as well as chemical food additives and preservatives.…”

Section: Paleolithic Dietmentioning

confidence: 99%

“…There is a strict variation of the diet for individuals with autoimmune disease that also excludes eggs, nuts, and seeds, as these can be inflammatory or immunogenic in some patients. [100][101][102][103][104][105][106] Other variations of the diet exist, including the ketogenic Paleo diet, pegan (Paleo vegan) diet, and lacto-Paleo diet. 100 An often cited criticism of the Paleo diet is the low intake of calcium and risk for osteoporosis; however, consumption of calcium-rich foods or a calcium supplement can address this concern.…”

Section: Paleolithic Dietmentioning

confidence: 99%

Reexamining the Role of Diet in Dermatology

Svoboda¹,

Christopher²,

Shields³

2021

Cutis

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Patients are increasingly interested in dietary modifications that may influence skin appearance and aid in the treatment of cutaneous disease.• Although evidence-based dietary recommendations currently are limited, it is important for dermatologists to be aware of the varied and nuanced dietary interventions employed by patients.• There remains a lack of randomized controlled trials assessing the efficacy of various dietary interventions in the dermatologic setting.

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Palaeolithic Diet in Diabesity and Endocrinopathies – A Vegan’s Perspective

Cited by 13 publications

References 39 publications

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

The Post-hunter-gatherer Era Microbes Hypothesis for Chronic Inflammatory Diseases

Reexamining the Role of Diet in Dermatology

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