PAL spectroscopy and testing for potential carcinogens

Abstract

Chemical carcinogens are often strong electrophiles. The variation of the Ps formation probability versus concentration of the substance being tested in a solvent (modelling intracellular milieu) may serve as an indicator of carcinogenic properties of the solute. Being effectivescavengers of track electrons such chemicals strongly inhibit Ps formation.Tests carried out with a number of well‐known chemical compounds indicate this expectation and indicate the possibility of using PAL spectroscopy in the search for carcinogenic and anticarcinogenic agents. It is further shown that carcinogenic activity of macro‐samples seemto correlate well with their work function. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

Positronium in a Liquid Phase: Formation, Bubble State and Chemical Reactions

“…Therefore, there is a need for a fast and cheap method of testing such compounds. Positron annihilation spectroscopy may provide such a method [43,44]. This work is supported by the Russian Foundation of Basic Research (grant 11-03-…”

Detection of carcinogenic and anticancerogenic properties of chemicals by means of the positron annihilation lifetime spectroscopy

“…The first group is composed by substances with "low" WF values, less than 4 eV. They do not show carcinogenic effect [18]. On the contrary, one half of the substances in the other group, where WF exceeds 4 eV, are recognized as carcinogens.…”

“…Its similarity with the mechanism of the hydrogen formation has jointed positron chemistry with radiation chemistry. It is based on our proposed method for detecting carcinogens and anticarcinogens, the essence of which we now briefly reproduce [16][17][18].…”

“…Instead, it is sufficient to limit oneself to only one measurement of the yield of Ps in the test substance itself. As a result, the duration of [17,18]. In substances that biologists consider carcinogens, the probability of Ps formation does not exceed 2-3%.…”

Carcinogenicity Screening of Chemicals Using Positron Annihilation Spectroscopy

“…To measure this probability and predict carcinogenic hazard of the tested substances, one may use standard techniques of positron annihilation spectroscopy [7]. The proposed method also allows to estimate anticarcinogenic properties of chemical compounds by the presence of an antiinhibition effect of Ps formation [8].…”