Abstract:As a highly conserved and ubiquitously expressed serine/threonine kinase, p21-activated kinase 2 (Pak2) participates in diverse biologic events. However, its roles in mouse oocyte meiotic maturation remain unclear. The present study revealed that mouse oocytes depleted of Pak2 were unable to completely progress through meiosis and that a majority were arrested at metaphase I. Pak2 depletion thus prompted MI arrest and induced meiotic apparatus assembly defects in mouse oocytes, in part due to a reduction in po… Show more
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