PairK: Pairwise k-mer alignment for quantifying protein motif conservation in disordered regions
Jackson C. Halpin,
Amy E. Keating
Abstract:Protein-protein interactions are often mediated by a modular peptide recognition domain binding to a short linear motif (SLiM) in the disordered region of another protein. The ability to predict domain-SLiM interactions would allow researchers to map protein interaction networks, predict the effects of perturbations to those networks, and develop biologically meaningful hypotheses. Unfortunately, sequence database searches for SLiMs generally yield mostly biologically irrelevant motif matches or false positive… Show more
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