Paired organs-Should they be treated jointly or separately in internal dosimetry?

Parach, Ali Asghar; Rajabi, Hamid; Askari, M. A.

doi:10.1118/1.3637493

Cited by 8 publications

(19 citation statements)

References 23 publications

(31 reference statements)

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“…Several studies have assessed the applicability of the GATE Monte Carlo package for internal dosimetry of radionuclides and related applications [3,4,20,21]. A brief summary of these studies can be found in a published review by Sarrut et al [22].…”

Section: Introductionmentioning

confidence: 98%

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Asl

Nasseri

Parach

et al. 2015

Australas Phys Eng Sci Med

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Monte Carlo techniques are widely employed in internal dosimetry to obtain better estimates of absorbed dose distributions from irradiation sources in medicine. Accurate 3D absorbed dosimetry would be useful for risk assessment of inducing deterministic and stochastic biological effects for both therapeutic and diagnostic radiopharmaceuticals in nuclear medicine. The goal of this study was to experimentally evaluate the use of Geant4 application for tomographic emission (GATE) Monte Carlo package for 3D internal dosimetry using the head portion of the RANDO phantom. GATE package (version 6.1) was used to create a voxel model of a human head phantom from computed tomography (CT) images. Matrix dimensions consisted of 319 × 216 × 30 voxels (0.7871 × 0.7871 × 5 mm(3)). Measurements were made using thermoluminescent dosimeters (TLD-100). One rod-shaped source with 94 MBq activity of (99m)Tc was positioned in the brain tissue of the posterior part of the human head phantom in slice number 2. The results of the simulation were compared with measured mean absorbed dose per cumulative activity (S value). Absorbed dose was also calculated for each slice of the digital model of the head phantom and dose volume histograms (DVHs) were computed to analyze the absolute and relative doses in each slice from the simulation data. The S-values calculated by GATE and TLD methods showed a significant correlation (correlation coefficient, r(2) ≥ 0.99, p < 0.05) with each other. The maximum relative percentage differences were ≤14% for most cases. DVHs demonstrated dose decrease along the direction of movement toward the lower slices of the head phantom. Based on the results obtained from GATE Monte Carlopackage it can be deduced that a complete dosimetry simulation study, from imaging to absorbed dose map calculation, is possible to execute in a single framework.

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Section: Introductionmentioning

confidence: 98%

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Asl

Nasseri

Parach

et al. 2015

Australas Phys Eng Sci Med

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“…The SAF values reported by Parach et al . [10] and the maximum relative percentage difference (RD %) for each corresponding pair of organs were also included in the table. The comparison of electron SAFs was limited to five monoenergetic electrons since these energies were considered in the literature[10] to represent the average electron energy of 186 Re, 24 Na, 32 P, 90 Y, and 19 O radionuclides, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…On average, electron SAFs calculated by GATE Monte Carlo was also slightly higher values (+0.7%) for self-irradiation and lower values (−4.9%) for cross-irradiation than reported data from the literature. [10]…”

Section: Resultsmentioning

confidence: 99%

“…In contrast with photon energy, the average relative percentage differences are increasing with increasing electron energy for both self- and cross-irradiation. In other words, the maximum relative differences between the GATE and[10] results related to the electron energy 1200 keV for both self- and cross-irradiation.…”

Section: Resultsmentioning

confidence: 99%

“…The same SAF values calculated using the MCNP4B Monte Carlo code,[910] and the results were compared for quality assurance purpose. The relative percentage difference (RD %) between two corresponding photon and electron SAF values were calculated as:…”

Section: Methodsmentioning

confidence: 99%

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Specific absorbed fractions of internal photon and electron emitters in a human voxel-based phantom: A monte carlo study

et al. 2017

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The specific absorbed fraction (SAF) of energy is an essential element of internal dose assessment. Here reported a set of SAFs calculated for selected organs of a human voxel-based phantom. The Monte Carlo transport code GATE version 6.1 was used to simulate monoenergetic photons and electrons with energies ranging from 10 keV to 2 MeV. The particles were emitted from three source organs: kidneys, liver, and spleen. SAFs were calculated for three target regions in the body (kidneys, liver, and spleen) and compared with the results obtained using the MCNP4B and GATE/GEANT4 Monte Carlo codes. For most photon energies, the self-irradiation is higher, and the cross-irradiation is lower in the GATE results compared to the MCNP4B. The results show generally good agreement for photons and high-energy electrons with discrepancies within − 2% ±3%. Nevertheless, significant differences were found for cross-irradiation of photons of lower energy and electrons of higher energy due to statistical uncertainties larger than 10%. The comparisons of the SAF values for the human voxel phantom do not show significant differences, and the results also demonstrated the usefulness and applicability of GATE Monte Carlo package for voxel level dose calculations in nonuniform media. The present SAFs calculation for the Zubal voxel phantom is validated by the intercomparison of the results obtained by other Monte Carlo codes.

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Internal dosimetry for radioembolization therapy with Yttrium‐90 microspheres

Fallahpoor

Abbasi

Parach

et al. 2017

J Applied Clin Med Phys

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The absorbed doses in the liver and adjacent viscera in Yttrium‐90 radioembolization therapy for metastatic liver lesions are not well‐documented. We sought for a clinically practical way to determine the dosimetry of this advent treatment. Six different female XCAT BMIs and seven different male XCAT BMIs were generated. Using Monte Carlo GATE code simulation, the total of 100MBq 90Y was deposited uniformly in the source organ, liver. Self‐irradiation and absorbed doses in lung, kidney and bone marrow were calculated. The mean energy of Yittrium‐90 (i.e., 0.937 MeV) was used. The S‐values and equivalent doses in target organs were estimated. The dose absorbed in the liver was between 84 and 53 Gy and below the target of 80 to 150 Gy. The absorbed dose in the bone marrow, lungs, and kidneys are very low and below 0.1 , 0.4, and 0.5 Gy respectively. Our study indicates that larger activities than the conventional dose of 3 GBq may be both required and safe. Further confirmations in clinical settings are needed.

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Paired organs-Should they be treated jointly or separately in internal dosimetry?

Cited by 8 publications

References 23 publications

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Monte Carlo and experimental internal radionuclide dosimetry in RANDO head phantom

Specific absorbed fractions of internal photon and electron emitters in a human voxel-based phantom: A monte carlo study

Internal dosimetry for radioembolization therapy with Yttrium‐90 microspheres

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