Paired choice reaction tasks in patients with Parkinson's disease

Nakashima, Kenichiro; Shimoyama, Reiko; Takahashi, Kentaro

doi:10.1111/j.1600-0404.1993.tb04097.x

Cited by 11 publications

(3 citation statements)

References 18 publications

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“…Most studies focused on differences between various subgroups of PD (Pessiglione et al, 2005 ; O’Callaghan et al, 2013 ; Cohen et al, 2014 ; Marzinzik et al, 2015 ; Peterson et al, 2015 ). Other studies compared PD performance to that of healthy, age-matched controls (Nakashima et al, 1993 ; Cooper et al, 1994 ; Franz and Miller, 2002 ; Dujardin et al, 2013 ). However, few studies have sought to understand the effect of dopaminergic therapy on motor impulsivity in PD, contrasting performance in the ON and OFF dopaminergic states (Farid et al, 2009 ; Antonelli et al, 2014 ; Herz et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease

Yang

Lauzon

Seergobin

et al. 2018

Front. Hum. Neurosci.

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Parkinson’s disease (PD) is characterized by resting tremor, rigidity and bradykinesia. Dopaminergic medications such as L-dopa treat these motor symptoms, but can have complex effects on cognition. Impulse control is an essential cognitive function. Impulsivity is multifaceted in nature. Motor impulsivity involves the inability to withhold pre-potent, automatic, erroneous responses. In contrast, cognitive impulsivity refers to improper risk-reward assessment guiding behavior. Informed by our previous research, we anticipated that dopaminergic therapy would decrease motor impulsivity though it is well known to enhance cognitive impulsivity. We employed the Go/No-go paradigm to assess motor impulsivity in PD. Patients with PD were tested using a Go/No-go task on and off their normal dopaminergic medication. Participants completed cognitive, mood, and physiological measures. PD patients on medication had a significantly higher proportion of Go trial Timeouts (i.e., trials in which Go responses were not completed prior to a deadline of 750 ms) compared to off medication (p = 0.01). No significant ON-OFF differences were found for Go trial or No-go trial response times (RTs), or for number of No-go errors. We interpret that dopaminergic therapy induces a more conservative response set, reflected in Go trial Timeouts in PD patients. In this way, dopaminergic therapy decreased motor impulsivity in PD patients. This is in contrast to the widely recognized effects of dopaminergic therapy on cognitive impulsivity leading in some patients to impulse control disorders. Understanding the nuanced effects of dopaminergic treatment in PD on cognitive functions such as impulse control will clarify therapeutic decisions.

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Section: Introductionmentioning

confidence: 99%

Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease

Yang

Lauzon

Seergobin

et al. 2018

Front. Hum. Neurosci.

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“…In the evaluation of the patients' SF-36 quality of life physical and mental section scores, a statistically significant difference was not found between the prior to and after the exercise program values (p>0.05) ( difference. In the same study, it was determined that the difference between simple and optional MT durations was more significant in Parkinson's patients 6 . Since the shortening in HZ values was not found significant in this study, sufficient evidence could not be provided on this subject.…”

Section: Resultsmentioning

confidence: 94%

“…RT and MT are divided into two groups; (1) simple, where the stimulus and response are always the same, and (2) optional, where the stimulus and response can be different 4 . It is known that simple RT is disrupted and MT gets longer in PD [5][6][7] . There are studies in the literature about the positive effects of exercise on RT and MT.…”

Section: Introductionmentioning

confidence: 99%

Effects of a rehabilitation program for Parkinson’s patients on reaction and movement time: an electromyographic study

KIZIL

Öğüt

Okuyucu

et al. 2022

Cukurova Medical Journal

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Purpose: The aim of the study was to investigate the effects of a rehabilitation program consisting of specific exercises for Parkinson's Disease (PD) patients on reaction time (RT), movement time (MT), quality of life and disease activity. Materials and Methods: A total of 26 idiopathic PD patients were included in the study. The exercises specific to Parkinson’s were applied to the patients for 16 weeks. The evaluation of the patients were done before and after the treatment. The disease severity was measured with Unified Parkinson’s Disease Rating Scale (UPDRS), quality of life was measured with Short Form-36 (SF-36). RT and MT measurements were done electromyographically. Results: There was no statistically significant difference in UPDRS total and sub-section values and SF-36 quality of life evaluation before and after the exercise program. While a significant decrease was observed in the RT values of the patients after the 16 week exercise program compared to prior to the program (Deltoid RT 370.46 ± 25 to 219.58 ± 17, biceps RT 370.42 ± 27 to 216.49 ± 14 and triceps RT 445.21 ± 31 to 247.53 ± 23, respectively). Conclusion: In PD, the rehabilitation program specific to the disease leads to a significant decrease in RT. Although the exercise has no statistically significant effect on disease activity, quality of life and MT values, it was seen that it still led to improvement.

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Event‐Related desynchronization to contingent negative variation and Self‐Paced movement paradigms in Parkinson's disease

et al. 1998

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The event-related desynchronization (ERD) to voluntary movement is an indicator of cortical activation with a high time resolution and a specific spatial representation. We have evaluated 10 patients affected by Parkinson's disease (PD), free from L-dopa treatment for at least 12 hours, and 10 control subjects. Each subject underwent ERD examination during self-paced movement (SPM) and during contingent negative variation (CNV) paradigms. ERD was measured as the percentage decrease of alpha band power and calculated for frequency bands of 1 Hz, ranging between 8 and 12 Hz. For group comparisons, the frequency showing the highest ERD was selected for each subject and for each side. In the control group, ERD in the CNV paradigm began over the contralateral centroparietal electrodes 1475 ms before movement onset of the right hand and 1375 ms for the left. In the SPM paradigm, ERD started over the contralateral central electrodes 2150 ms and 1775 ms before movement onset of the right and left hand, respectively. In the PD group, ERD started over the contralateral central areas 800 ms and 475 ms before movement onset of the right and left hand, respectively, for CNV paradigm and 1200 ms and 750 ms for the right and left hand, respectively, for SPM paradigm. Therefore, contralateral ERD began closer to movement onset in PD compared with the control group in both paradigms. ERD over the sensorimotor areas ipsilateral to the movement was not significantly different in PD compared with the control group. The finding of delayed contralateral ERD in PD is according to the view that functional cortical activation related to movement preparation is impaired in PD. The lack of group differences in the onset of ipsilateral ERD, which appears close to movement execution than contralateral ERD both in normal subjects and in PD, suggests that different mechanisms may be involved in generating ERD over the hemispheres ipsilateral and contralateral to the movement, and that only the latter are impaired in PD.

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Paired choice reaction tasks in patients with Parkinson's disease

Cited by 11 publications

References 18 publications

Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease

Dopaminergic Therapy Increases Go Timeouts in the Go/No-Go Task in Patients with Parkinson’s Disease

Effects of a rehabilitation program for Parkinson’s patients on reaction and movement time: an electromyographic study

Event‐Related desynchronization to contingent negative variation and Self‐Paced movement paradigms in Parkinson's disease

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