Painless Acanthamoeba keratitis

Kent, Shefalee S.; Robert, Marie-Claude; Tokarewicz, Alexander C.; Mather, Rookaya

doi:10.1016/j.jcjo.2012.04.015

Cited by 8 publications

(2 citation statements)

References 14 publications

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“…In a recent published series, a typical presentation with disproportionate pain, ring infiltrates, and radial keratoneuritis was observed in less than a third of cases [3]. Cases of painless AK with normal vision have also been reported [14][15][16]. The first patient of our series presented with severe anterior segment involvement, with no complain of ocular pain even after the onset of scleritis.…”

Section: Discussionmentioning

confidence: 55%

Acanthamoeba Ocular Infection: Anomalous Presentation of a Potentially Vision-Threatening Condition

Fasciani

Brocca

Agresta

et al. 2018

SN Compr. Clin. Med.

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Section: Discussionmentioning

confidence: 55%

Acanthamoeba Ocular Infection: Anomalous Presentation of a Potentially Vision-Threatening Condition

Fasciani

Brocca

Agresta

et al. 2018

SN Compr. Clin. Med.

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“…The degree of pain is classically described to be severe and disproportionate to the clinical picture [ 32 , 39 ]. However, AK can also be painless, leading to diagnostic uncertainties [ 40 , 41 , 42 ]. Dendritiform epitheliopathy resembling Herpes simplex keratitis (HSK), either with or without stromal and endothelial inflammation, often develops in the early stages of AK cases [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Acanthamoeba Keratitis: Past, Present and Future

Azzopardi

Chong

et al. 2023

Diagnostics

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Acanthamoeba keratitis (AK) is a painful and sight-threatening parasitic corneal infection. In recent years, the incidence of AK has increased. Timely and accurate diagnosis is crucial during the management of AK, as delayed diagnosis often results in poor clinical outcomes. Currently, AK diagnosis is primarily achieved through a combination of clinical suspicion, microbiological investigations and corneal imaging. Historically, corneal scraping for microbiological culture has been considered to be the gold standard. Despite its technical ease, accessibility and cost-effectiveness, the long diagnostic turnaround time and variably low sensitivity of microbiological culture limit its use as a sole diagnostic test for AK in clinical practice. In this review, we aim to provide a comprehensive overview of the diagnostic modalities that are currently used to diagnose AK, including microscopy with staining, culture, corneal biopsy, in vivo confocal microscopy, polymerase chain reaction and anterior segment optical coherence tomography. We also highlight emerging techniques, such as next-generation sequencing and artificial intelligence-assisted models, which have the potential to transform the diagnostic landscape of AK.

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Corneal Diseases in Children: Infectious Keratitis

Koo¹,

Colby

2017

Essentials in Ophthalmology

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Painless Acanthamoeba keratitis

Cited by 8 publications

References 14 publications

Acanthamoeba Ocular Infection: Anomalous Presentation of a Potentially Vision-Threatening Condition

Acanthamoeba Ocular Infection: Anomalous Presentation of a Potentially Vision-Threatening Condition

Diagnosis of Acanthamoeba Keratitis: Past, Present and Future

Corneal Diseases in Children: Infectious Keratitis

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