Painful Indurated Erythema Suggestive of Kikuchi‐Fujimoto Disease in a Patient with Primary Sjögren's Syndrome

Miyashita, Yuko; Yamaguchi, M; Fujimoto, Wataru

doi:10.1111/j.1346-8138.2003.tb00443.x

Cited by 15 publications

(14 citation statements)

References 16 publications

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“…One was a 24-year-old women patient from Turkey with no follow-up data 40 while one other had skin lesions pathologically resembling KFD, 26 years after initial diagnosis of SjS. 41 A recent case series with long follow-up data reported 2 additional patients who developed Sjögren's syndrome after 2 and 10 years, respectively, following the diagnosis of KFD. 25 KFD has a variably reported recurrence rate ranging from 3% to as high as 31% in some series.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Histiocytic Necrotizing Lymphadenitis With a Long Latency in a Patient With Autoimmunity

Bogusz

Bhargava

2012

Int J Surg Pathol

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Kikuchi-Fujimoto disease (KFD), a histiocytic necrotizing lymphadenitis (HNL), characteristically presents as cervical lymphadenopathy in young Asian women. Most resolve spontaneously with rare recurrences described. We report a patient with biopsy-proven recurrence of KFD-like HNL after almost 8 years and analyze 65 additional published cases with recurrences. While those with recurrences similarly affect young (average age = 27 years), Asian (80%) women (76%), 73% had multiple sites of involvement and 32% of those tested had underlying autoimmune conditions. Our case is unusual with respect to the following: (a) Age: 50 years, the oldest among the reported patients with recurrences. (b) Race: African descent, with only 3 others reported with recurrent HNL. Of these 4 cases, 2 had underlying autoimmunity. (c) Underlying condition: Her clinical and laboratory features were best felt to represent Sjögren's syndrome (SjS). Only 2 other cases of SjS-associated HNL have been reported; in 2 recently reported cases SjS developed subsequently.

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Section: Discussionmentioning

confidence: 99%

Recurrent Histiocytic Necrotizing Lymphadenitis With a Long Latency in a Patient With Autoimmunity

Bogusz

Bhargava

2012

Int J Surg Pathol

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“…The lack of detection of monoclonal lymphocyte receptors rules out the possibility of lymphoma. 8,11,17,18 Fine-needle aspiration biopsy has an accuracy of 56%. 1,3,8,19 The differential diagnosis includes lymphoma, SLE, cat-scratch disease, Still's disease, infectious mononucleosis, drug eruptions, 5 viral lymphadenitis and tuberculosis.…”

Section: 9mentioning

confidence: 99%

“…8,11,17,18 Fine-needle aspiration biopsy has an accuracy of 56%. 1,3,8,19 The differential diagnosis includes lymphoma, SLE, cat-scratch disease, Still's disease, infectious mononucleosis, drug eruptions, 5 viral lymphadenitis and tuberculosis. 5,7,10,12,17,18 No therapy has been found to be effective so far for the treatment of histiocytic necrotizing lymphadenitis.…”

Section: 9mentioning

confidence: 99%

“…3,6,7 Rheumatological diseases such as SLE and Sjögren's syndrome may be associated with KFD, and therefore, investigation of the presence of these diseases and patient follow-up are necessary. 8 The etiology of Kikuchi-Fujimoto disease is uncertain, and speculations exist regarding relationships with previous viral infections or autoimmune processes. [1][2][3] We present three cases involving female patients of non-Asian origin with Kikuchi-Fujimoto disease who were seen between 2003 and 2006 at our outpatient department, along with a short review of the literature.…”

Section: Introductionmentioning

confidence: 99%

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Kikuchi-Fujimoto disease: three case reports

et al. 2010

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CONTEXT: Kikuchi-Fujimoto disease (KFD) manifests in most cases as unilateral cervical lymphadenomegaly, with or without accompanying fever.The disease mainly affects young women and has a self-limited course. It is more common in oriental countries, with few reports of its occurrence in Brazil. KFD should be included in the differential diagnosis of suspected cases of viral infections, tuberculosis, reactive lymphadenitis, systemic lupus erythematosus and metastatic diseases. It can be histologically confused with lymphoma. The disease is benign and self-limiting and an excisional biopsy of an affected lymph node is necessary for diagnosis. There is no specific therapy. CASE REPORTS:This study reports on three cases of non-Asian female patients with KFD who were attended at our service between 2003 and 2006. A review of the literature was carried out, with a systematic search on this topic, with the aim of informing physicians about this entity that is manifested by cervical masses and fever.RESUMO CONTEXTO: A doença de Kikuchi-Fujimoto (DKF) se manifesta na maioria das vezes como linfadenomegalia cervical unilateral, que pode ser acompanhada de febre. Afeta principalmente mulheres jovens, com evolução autolimitada. A prevalência desta doença é mais comum no oriente, havendo poucos relatos de sua ocorrência em nosso meio. DKF deve ser incluída no diagnóstico diferencial de casos suspeitos de infecções por vírus, tuberculose, linfadenite reacional, lúpus eritematoso sistêmico e doença metastática. Histologicamente pode ser confundida com linfoma. A doença é de caráter benigno, auto-limitada, a biópsia excisional do linfonodo acometido é necessária para o diagnóstico e não há tratamento específico. RELATO DE CASOS:Este trabalho relata três casos de pacientes não asiáticas do sexo feminino com DKF, atendidas em nosso serviço entre 2003 e 2006, e faz revisão da literatura com uma busca sistematizada sobre o assunto, com o objetivo de informar os médicos sobre essa entidade que se manifesta com massa cervical e febre.

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“…Additional profiles of auto-antibody titer suggested a diagnosis of Sjogren's syndrome. Concurrent KFD and Sjogren's syndrome have been described in previous reports [21,22]. Some young children with Sjogren's syndrome experience uncontrolled inflammation.…”

Section: Discussionmentioning

confidence: 83%

Kikuchi–Fujimoto disease developed into autoimmune disease: a report of two cases

et al. 2010

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We report herein the pathological findings and clinical courses of two cases of Kikuchi-Fujimoto disease (KFD) that developed into autoimmune diseases. The patients are currently undergoing treatment for a disease similar to Sjogren's syndrome and systemic lupus erythematosus/mixed connective tissue disease. KFD is not an independent condition and most likely develops due to an autoimmune mechanism. Pediatricians should pay careful attention to KFD and encourage long-term follow-up in patients with this condition.

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Painful Indurated Erythema Suggestive of Kikuchi‐Fujimoto Disease in a Patient with Primary Sjögren's Syndrome

Cited by 15 publications

References 16 publications

Recurrent Histiocytic Necrotizing Lymphadenitis With a Long Latency in a Patient With Autoimmunity

Recurrent Histiocytic Necrotizing Lymphadenitis With a Long Latency in a Patient With Autoimmunity

Kikuchi-Fujimoto disease: three case reports

Kikuchi–Fujimoto disease developed into autoimmune disease: a report of two cases

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