Painful Eccrine Spiradenoma Containing Nerve Fibers: A Case Report

Park, Hye Ran; Im, Soo Bin; Kim, Hee Kyung; Shin, Dong Seong; Park, Young Lip

doi:10.1159/000339768

Cited by 12 publications

(9 citation statements)

References 36 publications

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“…Correct diagnosis is critical due to the potential for malignancy. The primarily clinical feature of ES is the presence of pain in the patient (8) and painful dermal tumors should be taken into consideration on initial evaluation. Entities including angioma, angioleiomyoma and neuroma should be considered in the further differential diagnosis of ES given their similar presentations.…”

Section: Discussionmentioning

confidence: 99%

Differential diagnosis of eccrine spiradenoma: A case report

Zheng

Tian

Wang

et al. 2014

Experimental and Therapeutic Medicine

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Eccrine spiradenoma (ES) is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. A 44-year-old male with a blue-colored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Dermatological examination was undertaken, followed by surgical excision of the subcutaneous lesion and histopathological examination of the tissue. Subjective symptoms included tenderness upon palpation and routine investigations were within normal limits. Immunohistochemical analysis of the tumor cells demonstrated positive staining for CK5/CK6, CK8/CK18, S100, as well as small vacuole-like positive for EMA, and was therefore diagnosed as ES. The results of the present study suggest that immunohistochemical assays may be helpful to clarify the diagnosis and differentiate ES from other painful subcutaneous tumors exhibiting similar clinical and histological presentations.

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Section: Discussionmentioning

confidence: 99%

Differential diagnosis of eccrine spiradenoma: A case report

Zheng

Tian

Wang

et al. 2014

Experimental and Therapeutic Medicine

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“…The characteristics of both tumors in all reported cases in the literature over the past 76 years are displayed in Table 1. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]…”

Section: Introductionmentioning

confidence: 99%

Spiradenoma of the breast and review of cases over 76-years

Dick

Sharma

2019

CRCP

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Spiradenomas stem from eccrine and apocrine glands to form benign cutaneous tumors. When arising on the breast, nipple, and areola region, spiradenomas can be difficult to differentiate from more worrisome breast masses. This is particularly true in patients with a prior history of breast cancer. These tumors can be mimicked by a wide range of adnexal growths and play a role in syndromic conditions. We present a case of a 56-year-old female with a 20-year enlarging left lower inner quadrant breast mass reviewed on mammography which was later excised and histopathologically diagnosed as a spiradenoma. Spiradenomas can be challenging to diagnose as they can present with similar findings on inexpensive and non-invasive testing such as ultrasound and mammogram. While a biopsy is a definitive tool for diagnosis, this is contraindicated in some spiradenoma mimickers such as epidermal cysts complicating diagnosis. To our knowledge, there are only six case reports of breast spiradenomas. We have reviewed the histopathology of this case and summarized all cases of breast spiradenomas and their malignant counterpart spiradenocarcinomas available in the literature compiling their presentations and imaging findings.

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“…Tumors arising from the sweat glands of the eyelids are uncommon, and the differences in their structure have given rise to much confusion [1-4]. A spiradenoma is a type of sweat gland tumor which has a comparatively good clinically course although it appears to be malignant [1,5].…”

Section: Introductionmentioning

confidence: 99%

Case of recurrence of spiradenoma in palpebral conjunctiva

et al. 2014

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BackgroundTo report a rare case of a recurrence of spiradenoma that developed in the upper eyelid.Case presentationA 49-year-old woman who had a second recurrence of a tumor in the right palpebral conjunctiva underwent local resection of the lesion with adjunctive cryotherapy to the surgical site. The tumor consisted of smooth, round to oval nodular lesions approximately 1–3 mm in size with enlarged blood vessels. Histopathologically, the solid and well-circumscribed nodule was located beneath the conjunctival epithelium. It was composed of cells with slightly basophilic-to-clear cytoplasm and round-to-oval nuclei arranged in a trabecular pattern. Periodic acid-Schiff stain was positive in the cytoplasm, and the staining disappeared after digesting by diastase. Many cells in mitosis were observed throughout the tumor but no necrotic cells. Immunohistochemistry showed that the Ki-67 labeling index was 12%. From these findings, we diagnosed this tumor as a recurrence of the spiradenoma. There has been no recurrence and no signs of malignancy in the 6 months after the surgical excision.ConclusionOur findings indicate that a spiradenoma should be completely excised surgically because of malignant transformation after repeated recurrences.

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Painful Eccrine Spiradenoma Containing Nerve Fibers: A Case Report

Cited by 12 publications

References 36 publications

Differential diagnosis of eccrine spiradenoma: A case report

Differential diagnosis of eccrine spiradenoma: A case report

Spiradenoma of the breast and review of cases over 76-years

Case of recurrence of spiradenoma in palpebral conjunctiva

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