Painful Diabetic Peripheral Neuropathy Study of Chinese Outpatients (PDNSCOPE): A Multicentre Cross-Sectional Registry Study of Clinical Characteristics and Treatment in Mainland China

Zhang, Yuanjin; Zhang, Shaowei; Pan, Liya; Wang, Baojun; Sun, Yuanlin; Gao, Lijun; Cui, Lijuan; Zhang, Qing; Shang, Heng; Jin, Suqin; Qin, Xing; Geng, Deqin; Yu, Xihe; Yang, Lin; Li, Li; Li, Zuoxiao; Yan, Chaoli; Sun, Hongbin; Sun, Tao; Du, Bo; Cao, Junying; Hu, Fengyun; Ma, Junwu; Zhou, Shiyue; Zhao, Fei; Wei, Li; Zheng, Jianmin; Yi, Yanhui; Xu, Jing; Hu, Bo; Sheng, Bao-Ying; Li, Zhaohui; Zhao, Zhigang; Yang, Ting; Wang, Ni; Zhao, Hong-Dong; Mima, Dunzhu; Qu, Huaiqian; Wang, Yi; Song, Fu-Xia; Li, Nan

doi:10.1007/s40122-021-00281-w

Cited by 8 publications

(6 citation statements)

References 41 publications

(54 reference statements)

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“…The prevalence of pDN varies among different studies, many reasons are due to the differences, containing case definition criteria used, participants selected, sample size, and types of diabetes ( Ziegler et al, 2014 ). Amazingly, a recent study has shown a higher prevalence of neuropathic pain in patients with pDN (73.11% of 1,547) in mainland China ( Zhang et al, 2021 ), all these data demonstrate the seriousness of pDN in diabetic patients. Itching is also a relatively frequent symptom in patients with diabetes.…”

Section: Epidemiologymentioning

confidence: 80%

Neuroinflammation Involved in Diabetes-Related Pain and Itch

et al. 2022

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Diabetes mellitus (DM) is a global epidemic with increasing incidence, which results in diverse complications, seriously affects the patient quality of life, and brings huge economic burdens to society. Diabetic neuropathy is the most common chronic complication of DM, resulting in neuropathic pain and chronic itch. The precise mechanisms of diabetic neuropathy have not been fully clarified, hindering the exploration of novel therapies for diabetic neuropathy and its terrible symptoms such as diabetic pain and itch. Accumulating evidence suggests that neuroinflammation plays a critical role in the pathophysiologic process of neuropathic pain and chronic itch. Indeed, researchers have currently made significant progress in knowing the role of glial cells and the pro-inflammatory mediators produced from glial cells in the modulation of chronic pain and itch signal processing. Here, we provide an overview of the current understanding of neuroinflammation in contributing to the sensitization of the peripheral nervous system (PNS) and central nervous system (CNS). In addition, we also summarize the inflammation mechanisms that contribute to the pathogenesis of diabetic itch, including activation of glial cells, oxidative stress, and pro-inflammatory factors. Targeting excessive neuroinflammation may provide potential and effective therapies for the treatment of chronic neuropathic pain and itch in DM.

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Section: Epidemiologymentioning

confidence: 80%

Neuroinflammation Involved in Diabetes-Related Pain and Itch

et al. 2022

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“…In addition, antidepressants are used effectively to treat depression (34). It has been determined that DPN patients with high depression screening test scores feel pain more (35).…”

Section: Discussionmentioning

confidence: 99%

A higher incidence of diabetic peripheral neuropathy may be associated with decreased sleep and increased depression in older adults

Öztorun

GÖZÜKARA>

Bahşi

et al. 2022

Journal of Health Sciences and Medicine

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Aim: Diabetes mellitus (DM) tends to increase with aging. Nearly half of the patients with DM develop neuropathy (DPN). Despite its high burden and morbidity, the conditions that DPN may be associated with have not been adequately studied in older adults. We aimed to identify sleep duration and comprehensive geriatric assessment components that may be associated with DPN. Material and Method: This is a cross-sectional retrospective study. DPN diagnosed with a medical history, neurologic examination, and electromyography (EMG). 125 diabetic older patients were included. All comprehensive geriatric assessment tests and questions about sleep quality and time were performed. We divided the patients into two groups those without neuropathy and with neuropathy and compared them. Results: The median age of 125 patients was 72 (min-max; 64-94). 58.8% of them were women. The percentage of married people and living with their spouse and slept for 6 hours or more had a lower percentage in the DPN group. Polypharmacy and the percentage of heart failure were significantly higher in the DPN group. Lawton-Brody score, which shows instrumental daily living activities (IADL) and geriatric depression score (GDS) was higher in the DPN group. In logistic regression, we found that depression scores were higher and sleep duration was shorter in the DPN group (respectively, odd ratio:265 p:.012; odd ratio:.1.917 p:.045) Conclusions: DPN in older adults may affect the functionality and be associated with fewer sleep hours and depression. Not only blood glucose regulation but also other factors such as sleep duration and depressed mood may be associated with DPN in older adults.

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“…Clinically, DM is associated with several complications that deeply compromise the quality of life and life expectancy. Among these complications, diabetic peripheral neuropathy (DPN) is the most debilitating and prevalent, affecting about 2/3 of DM patients (Garoushi et al, 2019 ; Pop‐Busui et al, 2017 ; Zhang et al, 2021 ). Additionally, there are many studies demonstrating that DPN can be present even in pre‐diabetic individuals (Kirthi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus differently affects electrical membrane properties of vagal afferent neurons of rats

Silva‐Alves

Ferreira-da-Silva

Coelho‐de‐Souza

et al. 2023

Physiological Reports

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To study whether diabetes mellitus (DM) would cause electrophysiological alterations in nodose ganglion (NG) neurons, we used patch clamp and intracellular recording for voltage and current clamp configuration, respectively, on cell bodies of NG from rats with DM. Intracellular microelectrodes recording, according to the waveform of the first derivative of the action potential, revealed three neuronal groups (A 0 , A inf , and C inf ), which were differently affected. Diabetes only depolarized the resting potential of A 0 (from −55 to −44 mV) and C inf (from −49 to −45 mV) somas. In A inf neurons, diabetes increased action potential and the after‐hyperpolarization durations (from 1.9 and 18 to 2.3 and 32 ms, respectively) and reduced dV/dt desc (from −63 to ‐52 V s −1 ). Diabetes reduced the action potential amplitude while increasing the after‐hyperpolarization amplitude of C inf neurons (from 83 and −14 mV to 75 and −16 mV, respectively). Using whole cell patch clamp recording, we observed that diabetes produced an increase in peak amplitude of sodium current density (from −68 to −176 pA pF −1 ) and displacement of steady‐state inactivation to more negative values of transmembrane potential only in a group of neurons from diabetic animals (DB2). In the other group (DB1), diabetes did not change this parameter (−58 pA pF −1 ). This change in sodium current did not cause an increase in membrane excitability, probably explainable by the alterations in sodium current kinetics, which are also induced by diabetes. Our data demonstrate that diabetes differently affects membrane properties of different nodose neuron subpopulations, which likely have pathophysiological implications for diabetes mellitus.

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Painful Diabetic Peripheral Neuropathy Study of Chinese Outpatients (PDNSCOPE): A Multicentre Cross-Sectional Registry Study of Clinical Characteristics and Treatment in Mainland China

Cited by 8 publications

References 41 publications

Neuroinflammation Involved in Diabetes-Related Pain and Itch

Neuroinflammation Involved in Diabetes-Related Pain and Itch

A higher incidence of diabetic peripheral neuropathy may be associated with decreased sleep and increased depression in older adults

Diabetes mellitus differently affects electrical membrane properties of vagal afferent neurons of rats

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