Pain TRP‐ed up by PARs

Surprenant, Annmarie

doi:10.1113/jphysiol.2006.126425

Cited by 8 publications

(5 citation statements)

References 8 publications

(14 reference statements)

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“…PAR2 agonists sensitize activation of TRPV4 by 4α‐PDD and hypotonic cell swelling probably via PLCβ, PKA, PKC and protein kinase D (Grant et al . , Surprenant ).In what concerns TRPV4 antagonism, the classic TRP channel blocker ruthenium red reversibly inhibits inward but not outward TRPV4 currents(Watanabe et al . ).…”

Section: Trp Antagonistsmentioning

confidence: 99%

Transient receptor potential channels in bladder function

et al. 2012

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The transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons. The urothelium and some interstitial cells also express several TRP channels. In this review, we describe the expression and the known roles of some members of TRP subfamilies, namely TRPV, TRPM and TRPA, in the urinary bladder. The therapeutic interest of modulating the activity of TRP channels to treat bladder dysfunctions is also discussed.

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Section: Trp Antagonistsmentioning

confidence: 99%

Transient receptor potential channels in bladder function

et al. 2012

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“…PAR2 is colocalized with PKC and PKA and causes upon stimulation PKC and PKA dependent activation of TRPV1 [63]. Activation of PAR2 causes via TRPV1 thermal hyperalgesia, which may underlie inflammatory pain [64,67].…”

Section: Modulationmentioning

confidence: 99%

Vanilloid Transient Receptor Potential Cation Channels: An Overview

Vennekens

Owsianik²,

Nilius³

2008

CPD

163

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The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ('Mucolipin') and the TRPA ('Ankyrin') group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-sensing (TRPV1, TRPV2, TRPV3, TRPV4) as well as highly Ca2+ selective channels involved in Ca2+ absorption/reabsorption in mammals (TRPV5, TRPV6). In this review we summarize fundamental physiological properties of all TRPV members in the light of various cellular functions of these channels and their significance in the systemic context of the mammalian organism.

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“…Of note, PAR-2 also sensitizes TRPV1 (Amadesi et al, 2004(Amadesi et al, , 2006 and TRPA1 (Tarada et al, 2013). Thus, PAR-2 appears to function as a regulator of TRP channels (Surprenant, 2007). Since gut bacteria produce high amounts of PAR-2, TRPV4 (along with TRPV1 and TRPA1) may be an attractive pharmacological target to relieve visceral pain.…”

Section: Transient Receptor Potential Channels: Acquired Diseasesmentioning

confidence: 99%