Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

Ganzewinkel, Christ-jan van; Been, Jasper V; Verbeek, Inge; Loo, Tera Boelen van der; Pal, S.M. van der; Kramer, Boris W.; Andriessen, Peter

doi:10.1016/j.earlhumdev.2017.05.001

Cited by 18 publications

(21 citation statements)

References 32 publications

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“…In our study, sex differences in sensory and pain thresholds (females more sensitive than males) were consistent across the VLBW and control groups. Although research on sex differences in pain sensitivity in the healthy population is not conclusive, 24 our findings agree with previous studies on thermal detection thresholds 4 and thermal and pressure pain 23 in healthy adults, as well as studies on pressure pain sensitivity 6 and cold pain sensitivity 31 among VLBW adolescents.…”

Section: Discussionsupporting

confidence: 89%

Pain Sensitivity and Thermal Detection Thresholds in Young Adults Born Preterm With Very Low Birth Weight or Small for Gestational Age at Term Compared With Controls

Iversen

Uglem

Indredavik

et al. 2018

The Journal of Pain

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Section: Discussionsupporting

confidence: 89%

Pain Sensitivity and Thermal Detection Thresholds in Young Adults Born Preterm With Very Low Birth Weight or Small for Gestational Age at Term Compared With Controls

Iversen

Uglem

Indredavik

et al. 2018

The Journal of Pain

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“…It was also observed that males with 15 and 180 days of life presented increased SP protein compared to females of the same age. This is consistent with the fact that women are less tolerant to painful procedures compared to men (Bartley and Fillingim, ), particularly when exposed to early pain (van Ganzewinkel et al, ).…”

Section: Discussionsupporting

confidence: 80%

Substance P in Dorsal Root Ganglion Neurons in Young and Adult Rats, after Nociceptive Stimulation during the Neonatal Period

Simões

Silva

Giorgetto

et al. 2018

The Anatomical Record

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The nervous system is highly plastic during the neonatal period, being sensitive to noxious stimuli, which may cause short- and long-term pain responsivity changes. Understanding plasticity in peripheral pain pathways is crucial, particularly when the nervous system is still under development and remodeling process. Substance P (SP) is widely used as a marker for peripheral neurons with unmyelinated and small myelinated fibers. We investigated the number of SP immunoreactive neurons in the dorsal root ganglion (DRG) of male and female Wistar rats, 15 and 180 days after nociceptive stimulation during the neonatal period. Right and left 5th lumbar (L5) DRG were incubated in rabbit polyclonal anti-substance P primary followed by biotinylated donkey anti-rabbit secondary antibodies. Reaction was revealed with a nickel-diaminobenzidine solution. Labeled neurons were counted and compared between ages, genders and groups. Gender differences were present in both ages, with the number of SP-positive DRG neurons being larger in 15-days-old males on both sides. After 180 days, males showed a larger number of SP-positive neurons than females only on the nociceptive stimulated side. An increased number of SP-positive neurons in the DRG on the stimulated side was present in females, immediately after nociceptive stimulation, but not after 180 days. In conclusion, neonatal noxious stimulation caused a permanent increase in SP-positive DRG neurons in males that was not observed in females, suggesting that differences in pain processing/responsivity between genders could be related to morphological alterations of the nervous system. Anat Rec, 301:849-861, 2018. © 2017 Wiley Periodicals, Inc.

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“…In prior research, school-aged children who had been born prematurely and hospitalized in NICU settings demonstrated altered pain responses and activation of specific brain regions by functional magnetic resonance imaging not evident in healthy controls (Hohmeister, Demirakça, Zohsel, Flor, & Hermann, 2008; Hohmeister et al, 2010; Slater et al, 2010; Walker, 2013). van Ganzewinkel et al (2017) conducted one of the largest studies of the later life effects of early exposure to painful experiences (412 adolescents, 19 years of age, born prematurely [gestational age <32 weeks] or with birth weight <1,500 g) and observed lower pain threshold and tolerance and higher pain intensity in these adolescents with experimentally induced pain using the cold pressor test.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic Modifications Following Noxious Stimuli in Infants

Hatfield

Hoffman

Polomano

et al. 2018

Biological Research For Nursing

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Pain threshold, tolerance and intensity in adolescents born very preterm or with low birth weight

Cited by 18 publications

References 32 publications

Pain Sensitivity and Thermal Detection Thresholds in Young Adults Born Preterm With Very Low Birth Weight or Small for Gestational Age at Term Compared With Controls

Pain Sensitivity and Thermal Detection Thresholds in Young Adults Born Preterm With Very Low Birth Weight or Small for Gestational Age at Term Compared With Controls

Substance P in Dorsal Root Ganglion Neurons in Young and Adult Rats, after Nociceptive Stimulation during the Neonatal Period

Epigenetic Modifications Following Noxious Stimuli in Infants

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