Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury

Rakhshandeh, Hassan; Ghorbanzadeh, Amirhosein; Negah, Sajad Sahab; Akaberi, Maryam; Rashidi, Roghayeh; Forouzanfar, Fatemeh

doi:10.1007/s11011-021-00773-w

Cited by 22 publications

(7 citation statements)

References 32 publications

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“… 28 Consistent with our results, Rakhshandeh et al reported potential neuroprotective effects of L. inermis due to its anti-oxidant, and anti-inflammatory effects manifested by decreased level of TNF-α. 29 …”

Section: Discussionmentioning

confidence: 99%

Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

Elebeedy¹,

Ghanem²,

El‐Sayed³

et al. 2022

IDR

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Purpose The developed resistance of pathogenic microorganisms towards the currently used antimicrobial agents requires the fast search for newer potent antimicrobials. One of the most important ways to combat the previously mentioned disaster is the use of natural alternatives like medicinal plants. Our study aimed to estimate the anti-inflammatory property, and antibacterial effects of probiotics Lactiplantibacillus plantarum and ethanol extracts of Lawsonia inermis leaves against Staphylococcus aureus when they were used separately or collectively as synergism. Material and Methods Experimentally induced infected wound model in mice was created and divided into 10 groups then treated for two days by L. plantarum and L. inermis individually or in combination, followed by biochemical assays. The antibacterial, anti-inflammatory, and wound healing activity were evaluated through histopathological sections taken before and after treatment. Results Our results revealed that L. plantarum and L. inermis mixture could inhibit growth of S. aureus and decrease the minimal inhibitory concentration (MIC) of L. plantarum to 2 mg/mL. The mixture decreased level of both interleukin 6 (IL-6) and interferon-alpha (TNF-α) to a level near the normal uninfected group. Histopathological study showed that animals treated with both L. plantarum and L. inermis had achieved almost 90% healing. Conclusion These results suggest that L. plantarum and L. inermis mixture has synergistic effect on healing of infected wound.

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Section: Discussionmentioning

confidence: 99%

Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

Elebeedy¹,

Ghanem²,

El‐Sayed³

et al. 2022

IDR

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“…L. inermis extract (250 mg/kg and 500 mg/kg) and gabapentin (100 mg/kg) were given intraperitoneally for 14 days following the CCI operation. According to the study's conclusions, L. inermis' anti-oxidant and anti-inflammatory activities may have neuroprotective effects against CCI-induced neuropathic pain (Rakhshandeh et al, 2021).…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 97%

An Up-to-Date Review on the Phytochemical and Pharmacological Aspects of the Lawsonia Inermis

2023

THE JAPS

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Medicinal plants are extensively used throughout the world to treat a variety of ailments because of their safety, efficacy and affordability. Lawsonia inermis or Henna is commonly used in folk medicine for the cure of several illnesses. Particularly, it is used as a hair and hand dye. The objective of this study is to offer the most recent information regarding the pharmacological and phytochemical profile of the medicinal plant that is backed by evidence. Only indexed research and review papers were taken into account for the present study's data gathering in order to ensure authenticity. Only articles published in English language were considered for this study. To conduct a literature survey, various databases such as Scopus, Google Scholar, PubMed, Science Direct, and MEDLINE were searched without any year limit. The following keywords are used to search the data: "Lawsonia inermis", "medicinal plants", "herbs", "phytochemical", "pharmacological", "in vivo", "in vitro", "Henna" and "toxicity". The study's findings showed that the plant contains a variety of potent phytochemicals, including Lawsona, linarigenin, linarisenin, luteolin, lawsochrysin, lawsoniaside, lawsonaphthoate e.tc. The fruits, leaves, and stems of L. inermis have all been demonstrated to have potential pharmacological effects in previous investigations. So far, its antioxidant, cytotoxic, antimicrobial, antiprotozoal, immunomodulatory, hypoglycemic, anti-inflammatory, and anticancer properties have been documented. Even though many aspects of the plant have been researched, additional study is still necessary to completely understand the mechanism behind its pharmacological actions, to confirm its medicinal efficacy, and to justify its usage in traditional medicine.

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“…Long-term use of analgesic drugs has its limitations, such as adverse effects and drug-to-drug interactions (Mercer Lindsay et al, 2021;Negah et al, 2021). Medicinal plants are a source of an infinite range of phytochemicals that have consistently been shown analgesic therapeutic properties (Forouzanfar et al, 2023;Negah et al, 2023;Rakhshandeh et al, 2021). A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications (Izzo et al, 2016).…”

Section: Painmentioning

confidence: 99%

Saffron (Crocus sativus) and its constituents for pain management: A review of current evidence

Pourbagher‐Shahri

Forouzanfar

2023

Phytotherapy Research

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Pain can become a chronic and deliberating experience with a significant burden. In preclinical and clinical studies, Saffron (Crocus sativus L.) has shown analgesic activities. Considering the unsatisfactory results of current therapeutic management for chronic pain conditions, we aimed to review saffron's analgesic activity and underlying mechanisms. Saffron showed antinociceptive activities in formalin‐, carrageenan‐, and capsaicin‐induced experimental pain models. Saffron analgesic activities affected several targets, including ion channels of nociceptors; the adrenergic system and central histaminic system; inhibition of inflammatory pathways, apoptotic pathways, and oxidative stress; regulation of NO pathway, and the endocannabinoid system. Clinical studies showed analgesia of Saffron in rheumatoid arthritis, after‐pain following childbirth, dysmenorrhea, and fibromyalgia. Our literature review showed that saffron can be beneficial as an adjunct therapy to commonly used analgesics in practice, particularly in chronic pain conditions.

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Pain-relieving effects of Lawsonia inermis on neuropathic pain induced by chronic constriction injury

Cited by 22 publications

References 32 publications

Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus

An Up-to-Date Review on the Phytochemical and Pharmacological Aspects of the Lawsonia Inermis

Saffron (Crocus sativus) and its constituents for pain management: A review of current evidence

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