Pain relief and pain intensity response to GLP-1 receptor agonist ROSE-010 in irritable bowel syndrome; clinical study cross-analysis with respect to patient characteristics

Touny, Aya A; Kenny, Enda; Månsson, Mattias; Webb, Dominic-Luc; Hellström, Per M.

doi:10.1080/00365521.2022.2041084

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…The secretion of glucagon-like peptide 1 (GLP-1) by L cells, expression of the surface receptor TGR5 by intestinal L cells, and induction of GLP-1 release from enteroendocrine cells by the TGR5 agonist 6α-ethyl-23(S)-methylcholic acid (EMCA, INT-777) inhibits glucagon secretion and gastric emptying and suppresses food uptake (Thomas et al, 2009 ). One study demonstrated that the glucagon-like peptide-1 receptor agonist ROSE-010 reduced pain during IBS episodes (Touny et al, 2022 ). However, GLP-1 acts on the enteric nervous system by reducing excitatory cholinergic neurotransmitters and regulating nitric oxide release through presynaptic GLP-1Rs (Amato et al, 2010 ).…”

Section: Endocrine System Abnormalitiesmentioning

confidence: 99%

A review of neuroendocrine immune system abnormalities in IBS based on the brain–gut axis and research progress of acupuncture intervention

et al. 2023

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Irritable bowel syndrome (IBS) is a common digestive disorder observed in clinics. Current studies suggest that the pathogenesis of the disease is closely related to abnormal brain–gut interactions, hypokinesia, visceral sensory hypersensitivity in the gastrointestinal tract, and alterations in the intestinal microenvironment. However, it is difficult for a single factor to explain the heterogeneity of symptoms. The Rome IV criteria emphasized the holistic biologic-psycho-social model of IBS, suggesting that symptoms of the disease are closely related to neurogastroenterology and various abnormalities in brain–gut interaction. This study comprehensively reviewed the relationship between the brain–gut axis and IBS, the structure of the brain–gut axis, and the relationship between the brain–gut axis and intestinal microenvironment, and discussed the relationship between the abnormal regulation of the nervous system, endocrine system, and immune system and the incidence of IBS on the basis of brain–gut axis. In terms of treatment, acupuncture therapy can regulate the neuroendocrine-immune system of the body and improve the intestinal microenvironment, and it has the advantages of safety, economy, and effectiveness. We study the pathogenesis of IBS from local to global and micro to macro, and review the use of acupuncture to treat the disease as a whole so as to provide new ideas for the treatment of the disease.

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Section: Endocrine System Abnormalitiesmentioning

confidence: 99%

A review of neuroendocrine immune system abnormalities in IBS based on the brain–gut axis and research progress of acupuncture intervention

et al. 2023

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“…In animal models, a GLP1 analogue or GLP1R agonist improved the visceral pain hypersensitivity in rats [ 110 , 111 ]. New evidence in clinical trials has shown that the subcutaneous injection of a GLP1 analogue, ROSE-010, decreased pain hypersensitivity [ 112 , 113 ]. Although these exogenous peptide treatment data strongly support the connection between GLP1 and visceral pain, less research has been performed to understand the effects of endogenous EECs-derived GLP1 in mediating visceral pain.…”

Section: Enteroendocrine Cells In Visceral Pain and Neuropathic Painmentioning

confidence: 99%

Involvement of Intestinal Enteroendocrine Cells in Neurological and Psychiatric Disorders

2022

Biomedicines

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Neurological and psychiatric patients have increased dramatically in number in the past few decades. However, effective treatments for these diseases and disorders are limited due to heterogeneous and unclear pathogenic mechanisms. Therefore, further exploration of the biological aspects of the disease, and the identification of novel targets to develop alternative treatment strategies, is urgently required. Systems-level investigations have indicated the potential involvement of the brain–gut axis and intestinal microbiota in the pathogenesis and regulation of neurological and psychiatric disorders. While intestinal microbiota is crucial for maintaining host physiology, some important sensory and regulatory cells in the host should not be overlooked. Intestinal epithelial enteroendocrine cells (EECs) residing in the epithelium throughout intestine are the key regulators orchestrating the communication along the brain-gut-microbiota axis. On one hand, EECs sense changes in luminal microorganisms via microbial metabolites; on the other hand, they communicate with host body systems via neuroendocrine molecules. Therefore, EECs are believed to play important roles in neurological and psychiatric disorders. This review highlights the involvement of EECs and subtype cells, via secretion of endocrine molecules, in the development and regulation of neurological and psychiatric disorders, including Parkinson’s disease (PD), schizophrenia, visceral pain, neuropathic pain, and depression. Moreover, the current paper summarizes the potential mechanism of EECs in contributing to disease pathogenesis. Examination of these mechanisms may inspire and lead to the development of new aspects of treatment strategies for neurological and psychiatric disorders in the future.

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Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome

O’Malley

2023

Visceral Pain

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Pain relief and pain intensity response to GLP-1 receptor agonist ROSE-010 in irritable bowel syndrome; clinical study cross-analysis with respect to patient characteristics

Cited by 5 publications

References 39 publications

A review of neuroendocrine immune system abnormalities in IBS based on the brain–gut axis and research progress of acupuncture intervention

A review of neuroendocrine immune system abnormalities in IBS based on the brain–gut axis and research progress of acupuncture intervention

Involvement of Intestinal Enteroendocrine Cells in Neurological and Psychiatric Disorders

Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome

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