Pain, Psychological Comorbidities, Disability, and Impaired Qualify of Life in Hidradenitis Suppurativa

Abstract

Purpose of Review Hidradenitis suppurativa (HS) is a chronic, painful dermatologic disease characterized by recurrent inflammatory nodules and abscesses of intertriginous areas such as the axilla and groin. People with HS suffer from greater pain and associated psychological comorbidities, including depression, anxiety, disability, and impairments in quality of life (QoL), compared to those with other dermatologic conditions. Our review focuses on the occurrence of pain and these relationships. Recent Findings The existing literature indicates that acute and chronic pain, depression, anxiety, and disability all contribute to poor quality of life in individuals with HS. Despite the central role of pain and distress in the presentation of HS, few studies have empirically evaluated the impact of pain and gaps remain in the existing psychosocial literature. There are no formal guidelines for treating HS-specific pain or psychological comorbidities. Summary The results of this review show a clear and pressing need to develop treatment recommendations and effective interventions for addressing acute and chronic pain, psychological comorbidities, disability, and impaired quality of life among people with HS. This review outlines a multidisciplinary approach to treating and managing pain and psychological comorbidities.

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

“…100 Another common association is seronegative arthritis, particularly spondylarthritis. 99,100,[105][106][107][108][109][110][111][112][113][114][115][116][117] The proper balance of intestinal Tregs and Th17 cells is important for intestinal homeostasis. 108,109 Increased Th17 cells and decreased Tregs have been reported in Crohn disease.…”

Depression Symptoms Predict Worse Clinical Response to Etanercept Treatment in Psoriasis Patients

“…In view of the fact that psychological problems have been reported to be associated with therapeutic effects in many chronic dermatologic disorders in previous studies [11, 12], we speculated that depression and anxiety might be associated with treatment outcomes in psoriasis patients. Therefore, the purpose of this study was to investigate the predictive values of depression and anxiety symptoms for clinical response to etanercept therapy in psoriasis patients.…”

Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (SHSA) 2017

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