Pain perception threshold in major depression

Adler, Georg; Gattaz, Wagner F.

doi:10.1016/0006-3223(93)90041-b

Cited by 133 publications

(66 citation statements)

References 7 publications

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“…Although depressed patients report significantly more frequent and intense pain, pain thresholds to pressure and cold stimuli may be increased (Lautenbacher et al, 1999). In contrast, depressed patients report a non-painful warm stimulus as more unpleasant compared with healthy control subjects (Strigo et al, 2008) and reduced pain perception threshold to a high frequency electrical skin stimulation (Adler and Gattaz, 1993). Due to the complex nature of the association between depression and pain, there is an increasing need to investigate the common neurobiological mechanisms that underlie this co-morbidity.…”

Section: Introductionmentioning

confidence: 99%

Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions

et al. 2010

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(2010). Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions. Neuroscience, 171: 1300-1313. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 Abbreviations: 5-HT serotonin; 5-HIAA 5-hydroxyindoleacetic acid; NA Noradrenaline; OB Olfactory Bulbectomy; PFC prefrontal cortex; SD Sprague Dawley; WKY Wistar-Kyoto rat 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 3 AbstractAltered pain responding in depression is a widely recognized but poorly understood phenomenon. The present study investigated nociceptive responding to acute (thermal and mechanical) and persistent (inflammatory) noxious stimuli in two animal models of depression, the olfactory bulbectomised (OB) and the Wistar-Kyoto (WKY) rat. In addition, this study examined if altered nociceptive behaviour was associated with changes in monoamine levels in discrete brain regions. OB rats exhibited mechanical allodynia (von Frey test) but not thermal hyperalgesia (hot plate and tail-flick tests) when compared to shamoperated counterparts. Formalin-induced nociceptive behaviour was both heightened and prolonged in OB versus sham-operated controls. An inverse correlation was observed between 5-hydroxyindoleacetic acid (5-HIAA) concentration in the hippocampus and amygdaloid cortex and nociceptive behaviour in the formalin test. In comparison, WKY rats exhibited thermal hyperalgesia in the hot plate test, while behaviour in the tail-flick and vonFrey tests did not differ between WKY and Sprague-Dawley rats. Furthermore, WKY rats exhibited enhanced formalin-evoked nociceptive responding up to 40 minutes post administration, an effect inversely correlated with serotonin and 5-HIAA levels in the hypothalamus. In conclusion, these findings demonstrate that altered pain responding observed in clinically depressed patients can be modelled pre-clinically, providing a means of investigating the neurochemical basis of, and possible treatments for, this phenomenon.Keyword: olfactory bulbectomy, Wistar-Kayto rat, hot plate, formalin test, mechanical allodynia, serotonin 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 4 The clinical connection between pain and depression has long been recognised.Epidemiological studies indicate that up to 66% of major depressed patients report co-morbid chronic pain (Bair et al., 2003;Bair et al., 2004;Arnow et al., 2006) and chronic pain patients are up ...

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Section: Introductionmentioning

confidence: 99%

Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions

et al. 2010

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“…In addition, it plays important roles in processes such as thermoregulation, antibody formation, vitamin D formation, lipid secretion, respiration, pigmentation and perception. [1][2][3][4][5][6] Stress disturbs the homeostasis, and may induce various disorders. For example, various kinds of physiological and psychological stress influence the hypothalamic-pituitaryadrenocortical axis, the hypothalamic-pituitary-gonadal axis, sympatho-adrenomedullary system and sympathetic nervous system, leading to changes in a number of organs.…”

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confidence: 99%

“…Gels were fixed by immersion in EtOH-H 2 O-AcOH (14 : 5 : 1) and scanned using a densitometer (Densitograph AE 6905, ATTO Corp., Tokyo). Control LDH isozymes, LDH 1 , LDH 2 , LDH 3 , LDH 4 and LDH 5 , were prepared from thymus of the hairless mouse. LDH activity of each isozyme was determined by multiplying the total LDH activity of each sample by the relative fraction of each isozyme determined by densitometry.…”

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confidence: 99%

Study of Active Substances Involved in Skin Dysfunction Induced by Crowding Stress. I. Effect of Crowding and Isolation on Some Physiological Variables, Skin Function and Skin Blood Perfusion in Hairless Mice.

Ishida

Mitsui

Nukaya

et al. 2003

Biological & Pharmaceutical Bulletin

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Human skin functions not only as a barrier to retain the internal components and to protect internal organs from external stimulation or invasion, but also as a sensory organ to maintain homeostasis. In addition, it plays important roles in processes such as thermoregulation, antibody formation, vitamin D formation, lipid secretion, respiration, pigmentation and perception. [1][2][3][4][5][6] Stress disturbs the homeostasis, and may induce various disorders. For example, various kinds of physiological and psychological stress influence the hypothalamic-pituitaryadrenocortical axis, the hypothalamic-pituitary-gonadal axis, sympatho-adrenomedullary system and sympathetic nervous system, leading to changes in a number of organs. Stress has been implicated in hypertension, arteriosclerosis, diabetes mellitus, and other diseases in clinical and epidemiological studies.7) Skin function should also be influenced by stress, because it is primarily regulated by the autonomic nervous system and the endocrine system. This idea is supported by clinical reports showing that some skin disorders, including psoriasis and atopic dermatitis, are exacerbated by anxiety. 8)In addition, recent cutaneous biological studies have revealed that immobilization stress and/or overcrowding stress induced a decrease in lipogenesis in sebaceous glands, delay of skin barrier recovery and disruption of the skin barrier in rats, Syrian hamsters, and/or BALB/c mice.9-11) Barrier function and water retention are important cutaneous functions to maintain homeostasis. However, the relationship between stressful stimuli and skin dysfunction has not been established yet.Psychological stress activates the sympathetic nervous system, resulting in increases in the levels of glucocorticoids, catecholamines and angiotensin II in the circulating blood. Excess of glucocorticoid and angiotensin II can elevate blood pressure and excess of catecholamine increases cardiac output and peripheral resistance. Thus, stress induces acute hypertonic and chronic circulatory disorders. Hypertension causes hematogeneous disorder in the microvasculature. Therefore, concomitant reduced blood supply may contribute to peripheral ischemia. It is also suggested that mental stress induces transient endothelial dysfunction in humans. 12) Indeed, it is well recognized that psychological stress elevates blood pressure and that long-term stress causes dysfunction of the skin and various organs, such as ovary, kidney, thymus and adrenal glands.Recently, the laser Doppler perfusion-imaging technique has made it possible to map accurately changes of blood perfusion over a large area with good time resolution, and this method has been used to measure microcirculatory changes of the skin, mucosa, kidney and eye. 13,14) It has also been used for detecting abnormal blood flow in pathologically changed skin. 15)In this study, we have examined the relationship between blood perfusion and skin dysfunction mediated by catecholamines in animals exposed to a crowded environment. This approach ha...

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“…Embora não existam estudos específicos dirigidos para a dor torácica não cardíaca, alguns dados indiretos dão suporte a essa hipótese. Em primeiro lugar, tem sido relatado que a depressão com sintomas ansiosos se associa a uma diminuição do limiar de percepção da dor 19 . Também se descreveu um uso excessivo dos serviços de saúde em pacientes com depressão em comorbidade com outras variedades da dor crônica 20 .…”

Section: Discussionunclassified

Depressão maior em pacientes com dor torácica não cardíaca: Quem vai tratar?

Fráguas

Nobre²,

Wajngarten³

et al. 2009

Rev. psiquiatr. clín.

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Objetivo: Investigar a presença de transtornos psiquiátricos em pacientes com dor torácica de origem não cardíaca que não respondem aos tratamentos regulares. Método: Dezoito pacientes com dor torácica sem origem cardíaca e considerados por seus clínicos como não respondentes aos tratamentos regulares instituídos foram avaliados por um psiquiatra treinado. As entrevistas foram realizadas com base no Present State Examination e os diagnósticos psiquiá-tricos, de acordo com os critérios do Manual de Diagnóstico e Estatística da Associação Psiquiátrica Americana, 3ª Edição Revisada (DSM-III-R). Resultados: Depressão maior no momento da avaliação foi diagnosticada em 6 (30%) pacientes, somatização em 1 (6%) e transtorno do pânico em 1 (6%) paciente. Sete pacientes estavam recebendo antidepressivos tricíclicos com doses < 75 mg/dia. Conclusões: A baixa dose de ADTs usadas para o tratamento da dor nesses pacientes pode ter melhorado parcialmente os sintomas depressivos, tornando mais difíceis o diagnóstico e o tratamento apropriado(s) da depressão e, assim, contribuindo para a persistência da dor e outras queixas. As futuras pesquisas deverão focalizar a eficácia do tratamento da depressão nesses pacientes e o impacto deste no alívio da dor torácica não cardíaca. Fráguas R, et al. / Rev Psiq Clín. 2009;36(3):83-7Palavras-chave: Depressão, cardiologia, dor, tratamento, atenção primária. AbstractObjective: To investigate the presence of psychiatric disorders in patients with chest pain not responsive to treatment. Method: We evaluated 18 patients judged by their physicians to have a chest pain not responsive to usual treatment, which included anti-pain medicines and investigation and treatment of possible etiological causes such as coronary artery disease, and gastroesophageal reflux disease. A psychiatrist interviewed the patients using the Present State Examination and made the diagnosis based on the DSM-III-R criteria. Current major depression was diagnosed in 6 (30%) patients, somatization in 1 (6%) and panic disorder in 1 (6%) patient. Seven patients were receiving tricyclics antidepressant with doses ≥ 75 mg/day. Discussion: Patients were receiving doses of tricyclics antidepressants efficacious for pain but not for major depression. It is possible that the low dose of antidepressants used to treat pain Chest Pain Outpatient Care Unit at

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Pain perception threshold in major depression

Cited by 133 publications

References 7 publications

Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions

Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions

Study of Active Substances Involved in Skin Dysfunction Induced by Crowding Stress. I. Effect of Crowding and Isolation on Some Physiological Variables, Skin Function and Skin Blood Perfusion in Hairless Mice.

Depressão maior em pacientes com dor torácica não cardíaca: Quem vai tratar?

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