Pain perception in people diagnosed with schizophrenia: where we are and where we are going

Sakson-Obada, Olga

doi:10.1080/17522439.2017.1344294

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…Similar findings of altered pain perception are shown in the schizophrenia literature, too (Sakson-Obada, 2017;Urban-Kowalczyk et al, 2015;Stubbs et al, 2015). Stubbs et al (2015) conducted a meta-analysis of all research conducted on pain perception in those with schizophrenia compared to healthy controls and found a consistent, moderate effect that those with schizophrenia-spectrum disorder had elevated pain thresholds (Hedge's g ¼ 0.493), with an even higher effect size in those who were not prescribed anti-psychotics (g ¼ 0.599), and an increased pain tolerance (g ¼ 0.566) and threshold (g ¼ 0.696) in those with a diagnosis of schizophrenia.…”

Section: The Role Of Endogenous Opioids In Social Bonding Disorderssupporting

confidence: 88%

The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids

Charles¹,

Farias²,

Dunbar³

2019

Preprint

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The American National Institute for Mental Health (NIMH) has put out a set of research goals that include a long-term plan to identify more reliable endogenous explanations for a wide variety of mental health disorders (Insel, 2013). In response to this, we have identified a major symptom that underlies multiple mental health disorders – social bonding dysfunction. We suggest that endogenous opioid abnormalities can lead to altered social bonding, which is a symptom of various mental health disorders, including depression, schizophrenia and ASD. This article first outlines how endogenous opioids play a role in social bonding. Then we show their association with the body’s inflammation immune function, and review recent literature linking inflammation to mental health ‘immunophenotypes’. We finish by explaining how these immunophenotypes may be caused by alterations in the endogenous opioid system. This is the first overview of the role of inflammation across multiple disorders where we provide a biochemical explanation for why immunophenotypes might exist across diagnoses. We propose a novel mechanism of how the immune system may be causing ‘sickness-type’ behaviours (fatigue, appetite change, social withdrawal and inhibited motivation) in those who have these immunophenotypes. We hope that this novel aetiology can be used as a basis for future research in mental health.

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Section: The Role Of Endogenous Opioids In Social Bonding Disorderssupporting

confidence: 88%

The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids

Charles¹,

Farias²,

Dunbar³

2019

Preprint

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“…In our study, we included 24 patients with SCZ and 12 healthy controls and we used the nociceptive reflex as the tool for pain assessment. We found that there was no significant difference between the case and control groups regarding the nociceptive threshold; however, there was significant difference regarding subjective pain threshold indicating that SCZ is associated with decreased pain sensitivity only when subjective pain assessment is tested as concluded in the systematic review done by Sakson-Obada, and that the physiological and basic affective responses to pain are intact, but the complex psychological elaboration seems to be impaired [6]. This is in agreement with Levesque et al, who used intermittent, transcutaneous stimulations of the left sural nerve, and found that, compared with controls, subjects with SCZ presented a specific experimental pain response profile, characterized by elevated sensitivity to acute pain but reduced sensitivity to prolonged pain.…”

Section: Discussionmentioning

confidence: 65%

“…Neuroleptic-induced analgesia, influence of neuropeptides with analgesic properties, lesions in the pain pathway, severe negative symptoms and cognitive impairment have been suggested. The hypothesis of an increased level of endogenous opioids was proposed but the results of the few studies are contradictory [6,7].…”

Section: Introductionmentioning

confidence: 99%

Nociceptive Reflex in Patients With Schizophrenia: A Case-Control Study

Elshony

Hamrawy

2021

J Neurol Res

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“…Current literature on the perceptions of pain in those with schizophrenia are mixed. Studies have found a decreased sensitivity to pain in patients with schizophrenia during laboratory nociceptive stimulations [10]. Patients with schizophrenia have also been found to show minor physical indications of pain when they have major medical injuries, and there is a low prevalence of schizophrenia diagnosis in chronic pain patients [11].…”

Section: Introductionmentioning

confidence: 99%

Pain and Psychotic-like Experiences in Young People Using Cannabis

Wilson

Constable

Mason

et al. 2022

The 3rd International Electronic Conference on Environmental Research and Public Health—Public Health Issues in the C

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Research has demonstrated that cannabis use is linked with a greater risk of psychoticlike experiences (PLEs), particularly in young people. As many use cannabis for the alleviation of pain, it is important to examine the impact that PLEs have on pain. This is because current literature finds that psychotic and schizophrenic disorders impact pain experience, and PLEs are subclinical positive symptoms of psychosis. There is limited research on the impact of PLEs on pain experience, particularly in cannabis users, and thus the current study aims to address this gap in the literature. The study also examines whether childhood trauma and mental health problems contribute to the heightened risk of pain in cannabis users, and whether these relationships are moderated by PLEs. The current study was a cross-sectional design in young cannabis users aged 18-25 (N = 2630). Participants completed questionnaire measures of cannabis use, PLEs, self-reported pain, childhood trauma, anxiety, and depression. Logistic regression analyses revealed that young cannabis users experiencing more PLEs reported significantly higher pain. Additionally, experiencing a history of childhood trauma and depression were also found to result in higher pain in these cannabis users. Moderation analyses revealed that PLEs moderated the relationship between depression and pain; however, in contrast to our predictions, PLEs did not moderate the relationship between childhood trauma and pain. Anxiety did not significantly predict higher pain. The results of the current study have important implications for the use and legalisation of THC medically and the social, emotional, and cognitive aspects of pain and cannabis use. We propose recommendations for mitigating the risk of PLEs associated with cannabis use in chronic pain patients medically prescribed THC for its analgesic effects and suggestions for future research.

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Pain perception in people diagnosed with schizophrenia: where we are and where we are going

Cited by 10 publications

References 24 publications

The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids

The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids

Nociceptive Reflex in Patients With Schizophrenia: A Case-Control Study

Pain and Psychotic-like Experiences in Young People Using Cannabis

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