Pain perception in Parkinson’s disease: A systematic review and meta-analysis of experimental studies

Thompson, Trevor; Gallop, Katy; Correll, Christoph U.; Carvalho, André F.; Veronese, Nicola; Wright, Ellen; Stubbs, Brendon

doi:10.1016/j.arr.2017.01.005

Cited by 40 publications

(27 citation statements)

References 57 publications

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“…Increased baseline pain sensitivity and the restoring effects of l ‐dopa on this sensitivity have previously been reported in patients with PD, 24,25 although the results are variable. For example, some studies using methods that incorporated substantial emotional‐motivational pain processing showed restoring effects of l ‐dopa on pain sensitivity, 26,27 whereas others with a stronger sensory‐discriminative focus did not find such effects 28,29 .…”

Section: Discussionmentioning

confidence: 93%

Recovery of Impaired Endogenous Pain Modulation by Dopaminergic Medication in Parkinson's Disease

et al. 2020

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Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcriptionprofiling data and in silico binding site prediction. Nucleic Acids Rese 2010;38(7):2332-2345. 13. Holmquist-Mengelbier L, Fredlund E, Lofstedt T, et al. Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 2006;10(5):413-423. 14. Uchida T, Rossignol F, Matthay MA, et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.

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Section: Discussionmentioning

confidence: 93%

Recovery of Impaired Endogenous Pain Modulation by Dopaminergic Medication in Parkinson's Disease

et al. 2020

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“…Another study 24 observed higher frequency of this non motor symptom in women. A higher risk for the development of pain was reported in female patients with PD, in patients with more severe parkinsonian symptoms, and in individuals with PD associated with motor complications and depression 25,26 . Nonetheless, these factors were not assessed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Should we retire statistical significance?

Correia¹,

Bagano²,

Melo³

2020

Brazilian Journal of Pain

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BACKGROUND AND OBJECTIVES: Low back pain is a non-motor symptom commonly reported by individuals with Parkinson's disease. The aim of this study was to identify the prevalence of low back pain and its characteristics in individuals with Parkinson disease from a specialized treatment center. METHODS: Individuals with idiopathic Parkinson's disease answered a questionnaire for the assessment of clinical parameters and associated pain symptoms. Pain intensity was assessed using the visual analog scale. RESULTS: One hundred and twenty-three patients with mean age 68.1±11.8 years, and disease duration of 7.0±4.9 years, answered the questionnaire. Pain was reported by 102 (82.9%) patients: 71 (57.7%) had low back pain and 31 (25.2%) had pain in other body segments. There was no difference in age, education, time of Parkinson's disease symptoms and diagnosis when comparing individuals with and without pain, as well as individuals with pain in other segments and low back pain. The group with low back pain had pain in a greater number of body segments in addition to the lumbar region, with longer duration of this symptom and more frequent use of analgesic drugs. In the low back pain group, women had greater pain intensity.

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“…Dopaminergic neurons affect nociceptive function in the spinal dorsal horn [32] and dopamine receptors are reportedly altered in patients with facial pain [33]. Interestingly, either too much or too little dopamine can produce pain [34], which is why both agonists [35] and antagonists such as antipsychotics can produce beneficial analgesic effects. A recently published article suggests that many antipsychotic drugs may prove, in the future, to be capable of providing effective analgesia [36].…”

Section: The Association Between Pain and Psychotropic Medications Inmentioning

confidence: 99%

Pain Sensitivity in Schizophrenia Spectrum Disorders: A Narrative Review of Recent Work

González-Rodríguez

Labad

Seeman

2021

Psychiatry International

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Many patients with schizophrenia seem relatively immune to physical pain while others complain of constant pain. This may result from disturbances or alterations of the sensory threshold for pain in populations with psychosis, a possibility for which there is some preliminary evidence. The inconsistency in pain perception may, in part, be explained by the treatments patients receive, but treatment-naïve patients also exhibit differences in response to pain. This suggests that decreased pain sensitivity may represent a specific psychosis endophenotype. Thus far, few experimental studies have investigated sensory thresholds, pain modalities, or other factors contributing to the perception or expression of physical pain in psychosis. A digital search for information on this topic was conducted in PubMed and Google Scholar. The result is a non-systematic, narrative review focusing on recent clinical and experimental findings of pain sensitivity in patients with psychosis. Importantly, physical and mental pain are closely connected constructs that may be difficult to differentiate. Our hope is that the review provides some clarity to the field in the specific context of schizophrenia.

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Pain perception in Parkinson’s disease: A systematic review and meta-analysis of experimental studies

Cited by 40 publications

References 57 publications

Recovery of Impaired Endogenous Pain Modulation by Dopaminergic Medication in Parkinson's Disease

Recovery of Impaired Endogenous Pain Modulation by Dopaminergic Medication in Parkinson's Disease

Should we retire statistical significance?

Pain Sensitivity in Schizophrenia Spectrum Disorders: A Narrative Review of Recent Work

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