Pain perception decrement produced through repeated stimulation

Ernst, Monique; Lee, Mathew H.M.; Dworkin, Barry R.; Zaretsky, Herbert H.

doi:10.1016/0304-3959(86)90077-1

Cited by 69 publications

(50 citation statements)

References 20 publications

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“…Additional correction of ocular artifacts was performed using blind source separation with independent components analysis (Jung et al, 2000) on epoched data. To reduce effects of pain habituation (Ernst et al, 1986;Milne et al, 1991;Valeriani et al, 2003), the first 10 trials of the experiment were eliminated, and counterbalance order was included as a between-subjects factor in ANOVAs to exclude variance attributable to habituation (supplemental data, available at www.jneurosci.org as supplemental material).…”

Section: Methodsmentioning

confidence: 99%

Visually Induced Analgesia: Seeing the Body Reduces Pain

Longo¹,

Betti²,

Aglioti³

et al. 2009

J. Neurosci.

230

272

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Given previous reports of strong interactions between vision and somatic senses, we investigated whether vision of the body modulates pain perception. Participants looked into a mirror aligned with their body midline at either the reflection of their own left hand (creating the illusion that they were looking directly at their own right hand) or the reflection of a neutral object. We induced pain using an infrared laser and recorded nociceptive laser-evoked potentials (LEPs). We also collected subjective ratings of pain intensity and unpleasantness. Vision of the body produced clear analgesic effects on both subjective ratings of pain and the N2/P2 complex of LEPs. Similar results were found during direct vision of the hand, without the mirror. Furthermore, these effects were specific to vision of one's own hand and were absent when viewing another person's hand. These results demonstrate a novel analgesic effect of non-informative vision of the body.

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Section: Methodsmentioning

confidence: 99%

Visually Induced Analgesia: Seeing the Body Reduces Pain

Longo¹,

Betti²,

Aglioti³

et al. 2009

J. Neurosci.

230

272

View full text Add to dashboard Cite

show abstract

“…These lower ratings could reflect differences in how we conducted pre-scanning training in Notes: df ¼ 1,40; þP < 0.10; *P < 0.05; **P < 0.01. that we used a relatively extensive training procedure to ensure that the participants fully understood the task. Speculatively, this different procedure may have resulted in habituation of controls' pain ratings while in the scanner (Ernst et al, 1986;Jempa et al, 2014). During the video viewing task, pain ratings were sensitive to both the Perspective and Effectiveness manipulations across both groups.…”

Section: Behavioral Responsesmentioning

confidence: 99%

Pain empathy in schizophrenia: an fMRI study

Horan

Jimenez

Lee

et al. 2016

Social Cognitive and Affective Neuroscience

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Although it has been proposed that schizophrenia is characterized by impaired empathy, several recent studies found intact neural responses on tasks measuring the affective subdomain of empathy. This study further examined affective empathy in 21 schizophrenia outpatients and 21 healthy controls using a validated pain empathy paradigm with two components: (i) observing videos of people described as medical patients who were receiving a painful sound stimulation treatment; (ii) listening to the painful sounds (to create regions of interest). The observing videos component incorporated experimental manipulations of perspective taking (instructions to imagine 'Self' vs 'Other' experiencing pain) and cognitive appraisal (information about whether treatment was 'Effective' vs 'Not Effective'). When considering activation across experimental conditions, both groups showed similar dorsal anterior cingulate cortex (dACC) and anterior insula (AI) activation while merely observing others in pain. However, there were group differences associated with perspective taking: controls showed relatively greater dACC and AI activation for the Self vs Other contrast whereas patients showed relatively greater activation in these and additional regions for the Other vs Self contrast. Although patients demonstrated grossly intact neural activity while observing others in pain, they showed more subtle abnormalities when required to toggle between imagining themselves vs others experiencing pain.

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“…Early studies by Buchsbaum and colleagues demonstrated naloxone-related hyperalgesia (Buchsbaum et al 1977;Davis et al 1978;Buchsbaum et al 1983), although these effects were limited to specific individuals (e.g., "pain insensitive" participants) or conditions (e.g., prolonged or intense stimulation). Other studies have reported that naloxone has no effect on forearm ischemic pain (Grevert and Goldstein 1977;Grevert et al 1983a;Grevert et al 1983b;Posner and Burke 1985), cold pressor pain (Grevert and Goldstein 1978;McCubbin and Bruehl 1994), or electrocutaneous pain in response to stimulation applied to the finger (Bromm et al 1983), forearm (El-Sobky et al 1976), ear (Stacher et al 1988), or teeth (Ernst et al 1986). Finally, a few studies have suggested that, in some cases, opioid antagonists may actually inhibit pain (Volavka et al 1979;Tassorelli et al 1995;Janssen and Arntz 1997).…”

Section: Introductionmentioning

confidence: 97%

Nociceptive flexion reflex and pain rating responses during endogenous opiate blockade with naltrexone in healthy young adults

Al’Absi

Ring

Harju

et al. 2007

Biological Psychology

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The effect of opioid blockade on nociceptive flexion reflex (NFR) activity and subjective pain ratings was examined in 151 healthy young men and women. Using a within-subjects design, NFR threshold was assessed on two days after administration of either placebo or a 50 mg dose of naltrexone. Electrocutaneous pain threshold and tolerance levels were measured after NFR threshold assessment on each day. Results indicated that administration of naltrexone was consistently associated with hypoalgesic responding. Specifically, participants exhibited lower levels of NFR activity and reported lower pain ratings for electrocutaneous stimulation delivered at pain threshold and tolerance levels following administration of naltrexone as compared to placebo. These findings indicate that opiate blockade using the current standard dose may elicit hypoalgesia. A potential moderating effect of dose of opiate blockade medication and level of endogenous opioid activation should be carefully examined in future research.

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Pain perception decrement produced through repeated stimulation

Cited by 69 publications

References 20 publications

Visually Induced Analgesia: Seeing the Body Reduces Pain

Visually Induced Analgesia: Seeing the Body Reduces Pain

Pain empathy in schizophrenia: an fMRI study

Nociceptive flexion reflex and pain rating responses during endogenous opiate blockade with naltrexone in healthy young adults

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