Pain Palliation in Patients with Bone Metastases Using MR-Guided Focused Ultrasound Surgery: A Multicenter Study

“…Liberman et al in 2009 published the first multicenter clinical study on the use of FUS for pain palliation of bone metastases [21]. This report includes previous pioneer work from [18] and [20], comprising 31 patients and 32 bone lesions.…”

Section: Metastatic Bone Tumorsmentioning

confidence: 99%

Focused ultrasound for treatment of bone tumours

Rodrigues

Stauffer

Vrba

et al. 2015

International Journal of Hyperthermia

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“…This technology is a noninvasive treatment modality that is FDA-approved for the treatment of uterine fibroids and bone metastasis. Several studies have demonstrated that focused ultrasound ablation can cause regression of uterine fibroids and alleviate pain from bone metastasis [12,15,20]. MRgFUS may also be useful in the treatment of extremity soft tissue tumors; however, investigations for this application have not to our knowledge been published.…”

Section: Introductionmentioning

confidence: 99%

Is MR-guided High-intensity Focused Ultrasound a Feasible Treatment Modality for Desmoid Tumors?

Avedian

Bitton

Gold

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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Background MR-guided high-intensity focused ultrasound is a noninvasive treatment modality that uses focused ultrasound waves to thermally ablate tumors within the human body while minimizing side effects to surrounding healthy tissues. This technology is FDAapproved for certain tumors and has potential to be a noninvasive treatment option for extremity soft tissue tumors. Development of treatment modalities that achieve tumor control, decrease morbidity, or both might be of great benefit for patients. We wanted to assess the potential use of this technology in the treatment of extremity desmoid tumors. Questions/purposes (1) Can we use MR-guided highintensity focused ultrasound to accurately ablate a predetermined target volume within a human cadaver extremity? (2) Does MR-guided high-intensity focused ultrasound treatment stop progression and/or cause regression of extremity desmoid tumors? Methods Simulated tumor volumes in four human cadavers, created by using plastic markers, were ablated using a commercially available focused ultrasound system. Accuracy was determined in accordance with the International Organization of Standards location error by measuring the farthest distance between the ablated tissue and the plane corresponding to the target. Between 2012 and 2014, we treated nine patients with desmoid tumors using focused ultrasound ablation. Indications for this were tumor-related symptoms or failure of conventional treatment. Of those, five of them were available for MRI followup at 12 months or longer (mean, 18.2 months; range, 12-23 months). The radiographic and clinical outcomes of five patients who had desmoid tumors treated with focused ultrasound were prospectively recorded. Patients were assessed preoperatively with MRI and followed at routine intervals after treatment with MRI scans and clinical examination. Results The ablation accuracy for the four cadaver extremities was 5 mm, 3 mm, 8 mm, and 8 mm. Four patients' tumors became smaller after treatment and one patient has slight progression at the time of last followup. The mean decrease in tumor size determined by MRI measurements was 36% (95% confidence interval, 7%-66%). No patient has received additional adjuvant systemic or local treatment. Treatment-related adverse events included first-and second-degree skin burns occurring in

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“…Moreover, external-beam radiation cannot reach the dose for killing the bone tumor because of nearby vital organs. Previously, multiple minimally invasive imageguided ablation strategies have been studied as treatments for painful bone metastases [23,24]. Cryoablation and RF ablation have been the most studied techniques demonstrating significantly reduced pain in patients who are unresponsive or incompletely responsive to standard conventional therapies.…”

Section: Discussionmentioning

confidence: 99%

125 I Brachytherapy in the Palliation of Painful Bone Metastases from Lung Cancer After Failure or Rejection of Conventional Treatments

Xiang

2017

Brachytherapy

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Pain Palliation in Patients with Bone Metastases Using MR-Guided Focused Ultrasound Surgery: A Multicenter Study

Abstract: The results suggest that MRgFUS has the ability to provide an accurate, effective, and safe noninvasive palliative treatment for patients with bone metastases.

Cited by 269 publications

References 36 publications

Focused ultrasound for treatment of bone tumours

Focused ultrasound for treatment of bone tumours

Is MR-guided High-intensity Focused Ultrasound a Feasible Treatment Modality for Desmoid Tumors?

125 I Brachytherapy in the Palliation of Painful Bone Metastases from Lung Cancer After Failure or Rejection of Conventional Treatments

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