Pain on injection with propofol

Gupta, S.; Ravalia, A.; Jonnada, H. R.

doi:10.1111/j.1365-2044.2001.2279-23.x

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…Propofol is insoluble in water and is prepared as fat emulsion. The most common side effects of propofol are local pain on injection site as well as blood pressure decline (1). The incidence of propofol pain varies from 28 % to 90% in different studies (2), with a single report of 85% in children (3).…”

Section: Introductionmentioning

confidence: 99%

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Gharavi¹,

Sabzevari²,

Ghorbanian³

et al. 2014

Iran Red Crescent Med J

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Background:Propofol is one of common anesthetic drugs used in anesthesia. The most common side effects of propofol are local pain. Pretreatment with lidocaine can reduce propofol injection pain.Objectives:The aim of the present study was to assess and compare the efficiency of lidocaine 0.4% and 2% in reducing the incidence and severity of propofol injection pain.Patients and Methods:This was a double blind prospective clinical trial on children 4-8 years old with class ASA I and II candidates who were referred to Dr. Shaikh Hospital in Mashhad for elective surgery. Sample size calculated 50 patients in each groups based on pilot study. 100 children's were randomly divided equally in two groups, who were injected with lidocaine solutions 2% and 0.4% respectively. patient's pain evaluation based on VSD (verbal descriptor scale) and NRS (Numeric Rating Scale) using patient's verbal reaction and behavior namely fretting, hand drag and tearing. The collated data was analyzed.Results:There was nosignificant difference as to the first three variables (age, gender and weight P > 0.2). The significant difference regarding pain experience in both groups was noteworthy (P > 0.2).Conclusions:Most of the studies compared lidocaine with other drugs or its efficiency at different doses. Our study is different in that we applied a constant dose of lidocaine in various volumes and concentration. This result shows that lidocaine with the same does but lower concentration and higher volume is more effective in preventing propofol injection pain. Using diluted lidocaine with the dosage of 1 mg/kg and a concentration of 0.4% is an effective way to relieve pain caused by propofol injection in children.

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Section: Introductionmentioning

confidence: 99%

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Gharavi¹,

Sabzevari²,

Ghorbanian³

et al. 2014

Iran Red Crescent Med J

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“…Procedural sedation with propofol has been shown to be safe and effective and is widely used (1–3). Notwithstanding its efficacy, propofol has some drawbacks, mainly pain on infusion and clinically far less relevant, hypotension (4). Lidocaine is frequently used to decrease the pain associated with propofol injection but the incidence of propofol infusion pain remains significant (5–8).…”

Section: Introductionmentioning

confidence: 99%

Pretreatment with intravenous ketamine reduces propofol injection pain

Barbi

Marchetti

Gerarduzzi

et al. 2003

Pediatric Anesthesia

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“…Propofol is the drug with Phenol structure whose common complication is pain at the injection site as well as low blood pressure. [ 1 ] It seems that its high solubility in fat causes pain induced by intravenous injection. To reduce the pain from the propofol injection with long-chain triglyceride, medium-chain triglyceride, and longer-chain triglyceride have been used.…”

Section: Introductionmentioning

confidence: 99%

Comparison the Effect of Granisetron and Dexamethasone on Intravenous Propofol Pain

et al. 2018

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Background:The incidence of propofol injection pain during induction of general anesthesia varies from 28% to 90%. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexamethasone and granisetron for reducing the incidence and severity of propofol injection pain.Materials and Methods:A total of 227 female subjects received 5 mL of preservative-free saline, 1 mg granisetron (5 ml), or 0.15 mg/kg of dexamethasone (5 ml), intravenously, following exsanguination and occlusion of the veins of the arm. This was followed by a 0.5 mg/kg injection of propofol. Pain scores and intensity of pain recorded immediately following the injection of propofol. Hemodynamic parameters and O2 sat were recorded 1, 3, 5, and 10 min after propofol injection.Results:The incidence pain following the injection of propofol was significantly decreased with both granisetron and dexamethasone (50.7% and 49.4%). Mean pain score in granisetron group was 3.16 ± 1.23, dexamethasone was 2.73 ± 1.03, and in saline group was 4.82 ± 1.73 (P = 0.001). Mean pain intensity in granisetron group was 1.16 ± 0.18, dexamethasone was 1.26 ± 0.14, and in saline group was 2.2 ± 0.99 (P = 0.001). There were no differences in either mean arterial pressure or O2 Sate at any time point after drugs injection among the groups. There was a significant difference in pulse rate in third minutes between three groups and in the group who received granisetron was lesser (P = 0.04).Conclusion:Pretreatment with intravenous granisetron (1 mg) and dexamethasone (0.15 mg/kg) before injection of propofol is effective and safe in reducing the incidence and severity of pain due to propofol injection.

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Pain on injection with propofol

Cited by 3 publications

References 3 publications

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Effect of Lidocaine Volume and Concentration on Preventing Incidence and Severity of Propofol Injection Pain

Pretreatment with intravenous ketamine reduces propofol injection pain

Comparison the Effect of Granisetron and Dexamethasone on Intravenous Propofol Pain

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