Pain May Promote Tumor Progression via Substance P–Dependent Modulation of Toll-like Receptor-4

Yang, Chao; Sun, Yunheng; Ouyang, Xueyan; Li, Jing; Zhu, Zhen; Yu, Rong; Wang, Li; Ji, Lin; Ding, Gang; Wang, Yaosheng; Jiang, Feng

doi:10.1093/pm/pnaa265

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Neurotransmitters, hormones, and signaling molecules have been shown to bridge the gap between nerves and tumors, and affect the growth and malignancy of tumor cells. For example, sympathetic and parasympathetic nerves can infiltrate the tumor microenvironment and actively stimulate the progression of cancer (23)(24)(25)(26). In recent years, as medical treatments have progressed, the psychological health and quality of life of cancer patients during the treatment process have been widely discussed (27).…”

Section: Discussionmentioning

confidence: 99%

Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells

Zhu

Yang

et al. 2021

Ann Transl Med

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Background: An increasing number of studies indicate that adrenergic signaling plays a fundamental role in tumor progression and metastasis induced by chronic stress. However, despite the growing attention, an understanding of the mechanisms linking chronic stress and cancer is still insufficient. Methods: Western blot analysis and transmission electron microscopy (TEM) were used to observe the changes in autophagy level in a breast cancer cell line (MCF-7) after epinephrine treatment. Non-targeted metabolomics was also used to detect MCF-7 metabolites after epinephrine treatment. The xenograft model was used to detect the level of autophagy after epinephrine intervention. Results: The results showed that epinephrine treatment reduced the autophagy level of breast cancer cells. Epinephrine changed the level of phosphatidylethanolamine (PE) in breast cancer cells as detected by nontargeted metabolomics. Epinephrine also changed autophagy in breast cancer cells by decreasing the level of PE in cells. When autophagy decreased, the invasion and migration of breast cancer cells increased in vitro, and the progression of breast cancer accelerated in vivo.Conclusions: These findings suggest that stress-related hormones affect the tumor progression of breast cancer. Therefore, strengthening the emotional management strategies of patients during the process of antitumor treatment as a supplement to the existing treatments may be beneficial.

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Section: Discussionmentioning

confidence: 99%

Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells

Zhu

Yang

et al. 2021

Ann Transl Med

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“…Indeed, several studies have demonstrated that neuropeptide receptors are expressed on tumor cells, and their binding to neuropeptide ligands regulates various processes, including proliferation, survival, adhesion, and migration. This is particularly noteworthy, which have been shown to be involved in the progression of various cancer types, as shown in gastric, breast, and oral cancers, namely, through binding of SP to NK-1R expressed by tumor cells (213,221,(229)(230)(231)(232)(233)(234)(235)(236)(237)(238)(239)(240)(241)(242). Thus, sensory innervation could affect tumor growth not only by acting on tumor cells but also on tumor vascularization.…”

Section: Influence Of Sensory Neurons On Cancer Growthmentioning

confidence: 99%

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

Mardelle,

Bretaud,

Daher

et al. 2024

Front. Immunol.

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The nervous and immune systems are the primary sensory interfaces of the body, allowing it to recognize, process, and respond to various stimuli from both the external and internal environment. These systems work in concert through various mechanisms of neuro-immune crosstalk to detect threats, provide defense against pathogens, and maintain or restore homeostasis, but can also contribute to the development of diseases. Among peripheral sensory neurons (PSNs), nociceptive PSNs are of particular interest. They possess a remarkable capability to detect noxious stimuli in the periphery and transmit this information to the brain, resulting in the perception of pain and the activation of adaptive responses. Pain is an early symptom of cancer, often leading to its diagnosis, but it is also a major source of distress for patients as the disease progresses. In this review, we aim to provide an overview of the mechanisms within tumors that are likely to induce cancer pain, exploring a range of factors from etiological elements to cellular and molecular mediators. In addition to transmitting sensory information to the central nervous system, PSNs are also capable, when activated, to produce and release neuropeptides (e.g., CGRP and SP) from their peripheral terminals. These neuropeptides have been shown to modulate immunity in cases of inflammation, infection, and cancer. PSNs, often found within solid tumors, are likely to play a significant role in the tumor microenvironment, potentially influencing both tumor growth and anti-tumor immune responses. In this review, we discuss the current state of knowledge about the degree of sensory innervation in tumors. We also seek to understand whether and how PSNs may influence the tumor growth and associated anti-tumor immunity in different mouse models of cancer. Finally, we discuss the extent to which the tumor is able to influence the development and functions of the PSNs that innervate it.

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“…When pain cannot be effectively assessed and treated, quality of life is reduced and treatment of underlying diseases may be impaired. 47,64 The presence of chronic pain can activate the hypothalamus-pituitary-adrenal axis and alter the function of the immune and endocrine systems. 26,28,46,49,68 At the Renmin Hospital of Wuhan University, a total of 663 patients with COVID-19 admitted between January 2020 and February 2020 were enrolled in a retrospective cohort study.…”

Section: Presence Of Pain May Affect the Recovery From Covid-19mentioning

confidence: 99%

Pain during and after coronavirus disease 2019: Chinese perspectives

Jiang

Yang

Wang

et al. 2021

PR9

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The coronavirus disease 2019 (COVID-19) global pandemic poses a major threat to human health and health care systems. Urgent prevention and control measures have obstructed patients' access to pain treatment, and many patients with pain have been unable to receive adequate and timely medical services. Many patients with COVID-19 report painful symptoms including headache, muscle pain, and chest pain during the initial phase of the disease. Persistent pain sequela in patients with COVID-19 has a physical or mental impact and may also affect the immune, endocrine, and other systems. However, the management and treatment of neurological symptoms such as pain are often neglected for patients hospitalized with COVID-19. Based on the China's early experience in the management of COVID-19 symptoms, the possible negative effects of preexisting chronic pain in patients with COVID-19 and the challenges of COVID-19 prevention and control bring to the diagnosis and treatment of chronic pain are discussed. This review calls to attention the need to optimize pain management during and after COVID-19.

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Pain May Promote Tumor Progression via Substance P–Dependent Modulation of Toll-like Receptor-4

Cited by 8 publications

References 32 publications

Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells

Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells

From pain to tumor immunity: influence of peripheral sensory neurons in cancer

Pain during and after coronavirus disease 2019: Chinese perspectives

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