Pain management of the cancer patient

Schug, Stephan A.; Chandrasena, Chandani

doi:10.1517/14656566.2015.980723

Cited by 54 publications

(47 citation statements)

References 87 publications

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“…For instance the Neuropathic Pain Assessment incorporates both qualitative descriptors according to the patient as well as clinical exam maneuvers for allodynia and hypesthesia . Distinguishing neuropathic from nociceptive pain is critical because co‐analgesics such as tricyclic antidepressants, gabapentin, pregabalin, and certain anticonvulsants may be more effective for neuropathic pain than opioids . Finally, patients were treated at a single institution, which may not necessarily represent opioid prescribing patterns on a national scale.…”

Section: Discussionmentioning

confidence: 99%

“…34 Distinguishing neuropathic from nociceptive pain is critical because co-analgesics such as tricyclic antidepressants, gabapentin, pregabalin, and certain anticonvulsants may be more effective for neuropathic pain than opioids. [35][36][37] Finally, patients were treated at a single institution, which may not necessarily represent opioid prescribing patterns on a national scale. Future studies involving prospective, multi-institutional data are warranted and may provide additional insights; however, the present study reflects the best available evidence on the topic.…”

Section: Discussionmentioning

confidence: 99%

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Opioid prescribing practices in patients undergoing surgery for oral cavity cancer

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Opioid prescribing practices in patients undergoing surgery for oral cavity cancer

et al. 2018

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“…The mainstay of cancer pain management is systemic pharmacotherapy [50]. The World Health Organization (WHO) has developed a 3-step pain ladder to help the health care professional effectively manage pain, classifying pain intensity according to severity and recommending analgesic agents based on their strength [51].…”

Section: General Approach In Cancer Pain Managementmentioning

confidence: 99%

Pain Management in Lung Cancer

Nurwidya

Syahruddin

Yunus

2016

Advances in Respiratory Medicine

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Lung cancer is the leading cause of cancer-related mortality worldwide. Not only burdened by the limited overall survival, lung cancer patient also suffer from various symptoms, such as pain, that implicated in the quality of life. Cancer pain is a complicated and transiently dynamic symptom that results from multiple mechanisms. This review will describe the pathophysiology of cancer pain and general approach in managing a patient with lung cancer pain. The use of opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and adjuvant analgesia, as part of the pharmacology therapy along with interventional strategy, will also be discussed.

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“…Unfortunately, current CIBP therapeutic strategies are still insufficient for some patients . One reason is related to the unwanted side effects of opiates and nonsteroidal anti‐inflammatory drugs . The other reason, may be due to an incomplete understanding of the underlying mechanisms of CIBP .…”

Section: Introductionmentioning

confidence: 99%

Spinal SET7/9 may contribute to the maintenance of cancer‐induced bone pain in mice

Hang

Wei

et al. 2017

Clin Exp Pharma Physio

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Cancer-induced bone pain (CIBP) profoundly influences patients' quality of life. Exploring the mechanisms by which CIBP occurs is essential for developing efficacious therapies. Various studies have shown that proinflammatory factors were involved in CIBP. SET domain containing lysine methyltransferase 7/9 (SET7/9) may modulate the expression of NF-κB-dependent proinflammatory genes in vitro. However, whether SET7/9 may participate in the maintenance of CIBP remains unknown. In this study, NCTC 2472 cells were inoculated into the intramedullary space of the femur to establish a mouse model of CIBP. Upregulation of spinal SET7/9 expression was related to pain behaviours in tumour-inoculated mice. Intrathecal cyproheptadine (10 or 20 nmol) attenuated response to painful stimuli in a dose-dependent manner. Moreover, there was a concomitant decrease in spinal SET7/9 and RANTES expression. The antinociceptive effects of cyproheptadine were abolished by pre-intrathecal administration of SET 7/9 (0.2 μg) for 30 minutes before intrathecal cyproheptadine (20 nmol) administration. These results indicated that spinal SET7/9 may contribute to the maintenance of CIBP in mice. Hence, targeting of spinal SET7/9 might be a useful alternative therapy for the treatment of CIBP.

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Pain management of the cancer patient

Abstract: There is a major need for more and better randomized controlled trials in the setting of cancer pain as the lack of evidence is hampering the improvement of current treatment guidelines.

Cited by 54 publications

References 87 publications

Opioid prescribing practices in patients undergoing surgery for oral cavity cancer

Opioid prescribing practices in patients undergoing surgery for oral cavity cancer

Pain Management in Lung Cancer

Spinal SET7/9 may contribute to the maintenance of cancer‐induced bone pain in mice

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