Pain Management in Older Adults with Chronic Wounds

Dubský, Michal; Fejfarová, Vladimı́ra; Bém, Robert; Jude, Edward B.

doi:10.1007/s40266-022-00963-w

Cited by 5 publications

(1 citation statement)

References 55 publications

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“…Ectopic pain often occurs following peripheral nerve injury and inflammation. In clinical practice, older people complain of pain more frequently than young people (30). The majority of elderly people also routinely experience pain in areas with no disease or injury (31).…”

Section: Discussionmentioning

confidence: 99%

Age-related Changes in Trigeminal Ganglion Macrophages Enhance Orofacial Ectopic Pain After Inferior Alveolar Nerve Injury

Fujiwara

Urata

Oto

et al. 2023

In Vivo

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Background/Aim: The ectopic pain associated with inferior alveolar nerve (IAN) injury has been reported to involve macrophage expression in the trigeminal ganglion (TG). However, the effect of age-related changes on this abnormal pain conditions are still unknown. This study sought to clarify the involvement of age-related changes in macrophage expression and phenotypic conversion in the TG and how these changes enhance ectopic mechanical allodynia after IAN transection (IANX). Materials and Methods: We used senescence-accelerated mouse (SAM)-prone 8 (SAMP8) and SAM-resistance 1 (SAMR1) mice, which are commonly used to study ageing-related changes. Mechanical stimulation was applied to the whisker pad skin under light anaesthesia; the mechanical head withdrawal threshold (MHWT) was measured for 21 d post-IANX. We subsequently counted the numbers of Iba1 (macrophage marker)-immunoreactive (IR) cells, Iba1/CD11c (M1-like inflammatory macrophage marker)-co-IR cells, and Iba1/CD206 (M2-like anti-inflammatory macrophage marker)-co-IR cells in the TG innervating the whisker pad skin. After continuous intra-TG administration of liposomal clodronate Clophosome® -A (LCCA) to IANX-treated SAMP8mice, the MHWT values of the whisker pad skin were examined. Results: Five days post-IANX, the MHWT had significantly decreased in SAMP8 mice compared to SAMR1-mice. Iba1-IR and Iba1/CD11c-co-IR cell counts were significantly increased in SAMP8 mice compared to SAMR1 mice 5 d post-IANX. LCCA administration significantly restored MHWT compared to control-LCCA administration. Conclusion: Ectopic mechanical allodynia of whisker pad skin after IANX is exacerbated by ageing, which involves increases in M1-like inflammatory macrophages in the TG.

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Section: Discussionmentioning

confidence: 99%