Pain management in Guillain–Barre syndrome: A systematic review

Peña, Laura; Moreno, Carlos B.; Gutiérrez-Álvarez, Ángela María

doi:10.1016/j.nrleng.2014.04.001

Cited by 13 publications

(19 citation statements)

References 40 publications

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“…Every year, 1.1 to 1.8 per 100,000 persons suffer from GBS [ 13 ]. It is caused by autoantibodies that attack peripheral nerve components [ 14 ]. The symptoms range from ascending bilateral limb weakness to decreased reflexes and severe back or extremity pain [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Pain drawings as a diagnostic tool for the differentiation between two pain-associated rare diseases (Ehlers-Danlos-Syndrome, Guillain-Barré-Syndrome)

Wester

Mücke

Bender

et al. 2020

Orphanet J Rare Dis

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Background The diagnosis of rare diseases poses a particular challenge to clinicians. This study analyzes whether patients’ pain drawings (PDs) help in the differentiation of two pain-associated rare diseases, Ehlers-Danlos Syndrome (EDS) and Guillain-Barré Syndrome (GBS). Method The study was designed as a prospective, observational, single-center study. The sample comprised 60 patients with EDS (3 male, 52 female, 5 without gender information; 39.2 ± 11.4 years) and 32 patients with GBS (10 male, 20 female, 2 without gender information; 50.5 ± 13.7 years). Patients marked areas afflicted by pain on a sketch of a human body with anterior, posterior, and lateral views. PDs were electronically scanned and processed. Each PD was classified based on the Ružička similarity to the EDS and the GBS averaged image (pain profile) in a leave-one-out cross validation approach. A receiver operating characteristic (ROC) curve was plotted. Results 60–80% of EDS patients marked the vertebral column with the neck and the tailbone and the knee joints as pain areas, 40–50% the shoulder-region, the elbows and the thumb saddle joint. 60–70% of GBS patients marked the dorsal and plantar side of the feet as pain areas, 40–50% the palmar side of the fingertips, the dorsal side of the left palm and the tailbone. 86% of the EDS patients and 96% of the GBS patients were correctly identified by computing the Ružička similarity. The ROC curve yielded an excellent area under the curve value of 0.95. Conclusion PDs are a useful and economic tool to differentiate between GBS and EDS. Further studies should investigate its usefulness in the diagnosis of other pain-associated rare diseases. This study was registered in the German Clinical Trials Register, No. DRKS00014777 (Deutsches Register klinischer Studien, DRKS), on 01.06.2018.

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Section: Introductionmentioning

confidence: 99%

Pain drawings as a diagnostic tool for the differentiation between two pain-associated rare diseases (Ehlers-Danlos-Syndrome, Guillain-Barré-Syndrome)

Wester

Mücke

Bender

et al. 2020

Orphanet J Rare Dis

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“…The other drugs used for neuropathic pain include tricyclic antidepressants, lidocaine, SSRI (selective norepinephrine and serotonin reuptake inhibitors), and topical capsaicin. 48 Adequate high-energy nutrition with high caloric protein diet should be instituted early through enteral feeding. 7 Nutrition plays an important role to prevent muscle wasting and helps in weaning patients from ventilatory support.…”

Section: General Supportive Carementioning

confidence: 99%

Management of Guillain-Barré Syndrome

Gopalakrishna

Ramesh

2019

Journal of Neuroanaesthesiology and Critical Care

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Guillain-Barré syndrome (GBS) is the most common, immune-mediated acute polyneuropathy characterized by variable degree of motor weakness, often presenting with quadriparesis. GBS with respiratory failure requiring endotracheal intubation with mechanical ventilation is common, affecting approximately 30% of patients. In addition, they present with sensory features, cranial nerve involvement, and autonomic disturbance. The majority of GBS patients have preceding respiratory tract infection or gastroenteritis. The diagnosis of GBS is based on clinical features supported by cerebrospinal fluid (CSF) examination and nerve conduction studies. Early course of the GBS requires meticulous monitoring and early initiation of immunotherapy. Plasma exchange (PE) and intravenous immunoglobulin (IVIg) are the proven therapies, and both have been shown to be equally effective. General supportive care is an important part of management of GBS. A multidisciplinary approach to prevent and manage potential complications in rapidly progressing GBS is important to reduce morbidity and mortality.

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“…The cardinal clinical features of Guillain-Barre syndrome (GBS) are: rapidly progressive, ascending muscle weakness, starting in the lower limbs and progressing to the upper limbs and face; poorly delimited distal sensory disorder in the limbs, accompanied by absent or reduced deep tendon reflexes [3,4]. Neurological symptoms reach the maximum degree of disability within a range of hours to four weeks.…”

Section: Clinical Conditionmentioning

confidence: 99%

“…Guillain-Barré Syndrome (GBS) is the most significant cause of generalized flaccid paralysis in the world [1,2], with an annual incidence of 1-4 cases per 100,000 population and a peak between 20 and 40 years of age [3]. GBS is an autoimmune disease that primarily affects the myelin of the proximal portion of the peripheral nerves, either acute or subacute.…”

Section: Introductionmentioning

confidence: 99%

Guillain-Barre syndrome

Lacerda

Galvão

Ferreira

et al. 2019

GSC Biol. and Pharm. Sci.

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Guillain-Barre syndrome is the most common and most severe acute flaccid paralysis, usually preceded by an infection or immune stimulation. A literature review of the last five years in Pubmed, Scopus, Embase, and Web of Science databases was done. Data were collected from epidemiological studies using the keywords. Guillain-Barrè syndrome (GBS) is an acute, severe, and fulminant polyradiculoneuropathy. It has ascending muscle weakness, rapid evolution, the involvement of respiratory muscles with an evolution period of up to four weeks. It has the Classic and Variant forms of clinical presentation. Guillain-Barrè Syndrome is a rapidly progressive disease. The diagnosis is clinical but requires exams such as electroneuromyography and cerebrospinal fluid analysis, so that treatment can be started as soon as possible to improve prognosis and increase survival of affected patients.

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Pain management in Guillain–Barre syndrome: A systematic review

Cited by 13 publications

References 40 publications

Pain drawings as a diagnostic tool for the differentiation between two pain-associated rare diseases (Ehlers-Danlos-Syndrome, Guillain-Barré-Syndrome)

Pain drawings as a diagnostic tool for the differentiation between two pain-associated rare diseases (Ehlers-Danlos-Syndrome, Guillain-Barré-Syndrome)

Management of Guillain-Barré Syndrome

Guillain-Barre syndrome

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