Introduction: Pain results from real or potential tissue damage that involves a disagreement sensory and emotional experience. Poor practice in post-operative pain management results in negative clinical outcomes, chronic pain, financial burden, and a reduction in patient functionality and productivity. The study was used for the hospitals administrations, health professionals, committee that develop the pain management guideline, researcher, and governmental health institutions regarding the practice of postoperative pain management. Objective: To assess postoperative pain management practices and associated factors towards healthcare professionals working in governmental hospitals in South Wollo Zone, Northeast Ethiopia, 2020. Method and Materials:-Cross-sectional study design was conducted from 20/02/2020 to 25/03/2020. The study population was selected from south Wollo zone governmental hospitals and 386 samples were collected using a selfadministered tool and verified, coded, and entered to Epi-data software version 3.1 and exported to SPSS software version 23 for analysis. To summarize descriptive statistics frequencies, percentages, and mean were used and presented with tables, charts, and figures. Result: The response rate of the study participants were 95.8%. Among the participants 57.5%, of the study respondents had good practice and 42.5% had poor practice of postoperative pain management. The variable, working intensive care unit (AOR (95%CI)=14.5 (1.503-139.93)), using assessment tool (AOR (95%CI)=10.622 (4.776-23.621)), using Pain scale (AOR (95%CI)=10. 614 (4.803-23.456)), Do documentation (AOR (95%CI)=6.748 (2.977-15.294)), take training (AOR (95%CI)=4.126 (1.707-9.977)), had past pain experience (AOR (95%CI)=4.174 (1.821-9.564)), favorable attitude (AOR (95%CI) =2.592 (1.191-5.643)); such independent variables were significantly association with the postoperative pain management practice. Conclusion: The overall level of poor postoperative pain management practice among health professionals in the study area was low.