Pain-Induced Beta Activity in the Subthalamic Nucleus of Parkinson’s Disease

Parker, Tariq; Huang, Yongzhi; Gong, Chen; Chen, Yue; Wang, Shouyan; Green, Alexander L.; Aziz, Tipu Z.; Li, Luming

doi:10.1159/000507032

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Studies in humans and rodents have revealed that the STN may play a significant role in pain perception and modulation. For instance, STN neurons have fast spontaneous firing and readily respond to painful stimuli 25,26 . Optogenetic activation of STN neurons decreases pain thresholds in mice 20 .…”

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confidence: 99%

A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors

et al. 2022

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The basal ganglia including the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) are involved in pain-related responses, but how they regulate pain processing remains unknown. Here, we identify a pathway, consisting of GABAergic neurons in the SNr (SNrGABA) and glutamatergic neurons in the STN (STNGlu) and the lateral parabrachial nucleus (LPBGlu), that modulates acute and persistent pain states in both male and female mice. The activity of STN neurons was enhanced in acute and persistent pain states. This enhancement was accompanied by hypoactivity in SNrGABA neurons and strengthening of the STN–LPB glutamatergic projection. Reversing the dysfunction in the SNrGABA-STNGlu-LPBGlu pathway attenuated activity of LPBGlu neurons and mitigated pain-like behaviors. Therefore, the SNrGABA-STNGlu-LPBGlu pathway regulates pathological pain and is a potential target for pain management.

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confidence: 99%

A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors

et al. 2022

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“…The functional connections between STN and pain processing regions in cortex, pedunculopontine nucleus, and parabrachial nucleus may play a role in this phenomenon ( 2 ). Additionally, STN local field potentials have been shown to respond to pain stimuli ( 30 ). However, the specific territories of STN involved in pain processing are not well understood.…”

Section: Discussionmentioning

confidence: 99%

Dorsal subthalamic deep brain stimulation improves pain in Parkinson's disease

Askari,

Lam,

Zhu

et al. 2023

Front. Pain Res.

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IntroductionInconsistent effects of subthalamic deep brain stimulation (STN DBS) on pain, a common non-motor symptom of Parkinson's disease (PD), may be due to variations in active contact location relative to some pain-reducing locus of stimulation. This study models and compares the loci of maximal effect for pain reduction and motor improvement in STN DBS.MethodsWe measured Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part I pain score (item-9), and MDS-UPDRS Part III motor score, preoperatively and 6–12 months after STN DBS. An ordinary least-squares regression model was used to examine active contact location as a predictor of follow-up pain score while controlling for baseline pain, age, dopaminergic medication, and motor improvement. An atlas-independent isotropic electric field model was applied to distinguish sites of maximally effective stimulation for pain and motor improvement.ResultsIn 74 PD patients, mean pain score significantly improved after STN DBS (p = 0.01). In a regression model, more dorsal active contact location was the only significant predictor of pain improvement (R2 = 0.17, p = 0.03). The stimulation locus for maximal pain improvement was lateral, anterior, and dorsal to that for maximal motor improvement.ConclusionSTN stimulation, dorsal to the site of optimal motor improvement, improves pain. This region contains the zona incerta, which is known to modulate pain in humans, and may explain this observation.

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“…The functional connections between STN and pain processing regions in cortex, pedunculopontine nucleus, and parabrachial nucleus may play a role in this phenomenon [2]. Additionally, STN local field potentials have been shown to respond to pain stimuli [30]. However, the specific territories of STN involved in pain processing are poorly described.…”

Section: Discussionmentioning

confidence: 99%

Dorsal Subthalamic Deep Brain Stimulation Improves Pain in Parkinson’s Disease

Askari

Lam

Zhu

et al. 2022

Preprint

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Introduction: Inconsistent effects of subthalamic deep brain stimulation (STN DBS) on pain, a common non-motor symptom of Parkinsons disease (PD), may be due to variations in active contact location relative to a pain-reducing locus of stimulation. Objective: To distinguish the loci of maximal effect for pain and motor improvement in the STN region. Methods: We measured Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS) Part I pain score (item-9), and MDS-UPDRS Part III motor score, preoperatively and 6-12 months after STN DBS. An ordinary least-squares regression model was used to examine active contact location as a predictor of follow-up pain score while controlling for baseline pain, age, dopaminergic medication, and motor improvement. An atlas-independent electric field model was applied to distinguish sites of maximally effective stimulation for pain and motor improvement. Results: In 74 PD patients, mean pain score significantly improved after STN DBS (p = 0.01). In a regression model, more dorsal active contact location was the only significant predictor of pain improvement (R2 = 0.17, p = 0.03). The stimulation locus for maximal pain improvement was lateral, anterior, and dorsal to that for maximal motor improvement. Conclusions: More dorsal STN DBS improves pain. Stimulation of the zona incerta, a region known to modulate pain in humans, may explain this observation.

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Pain-Induced Beta Activity in the Subthalamic Nucleus of Parkinson’s Disease

Cited by 6 publications

References 24 publications

A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors

A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors

Dorsal subthalamic deep brain stimulation improves pain in Parkinson's disease

Dorsal Subthalamic Deep Brain Stimulation Improves Pain in Parkinson’s Disease

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