Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease

Lawn, Timothy; Aman, Yahyah; Rukavina, Katarina; Sideris-Lampretsas, George; Howard, Matthew A.; Ballard, Clive; Malcangio, Marzia

doi:10.1097/j.pain.0000000000002111

Cited by 26 publications

(24 citation statements)

References 158 publications

(62 reference statements)

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“…Although there is an overlap between DLB and Parkinson's disease dementia (PDD), with some clinicians placing them on the same disease continuum, current consensus diagnostic criteria categorize them as two specific disorders based on the temporal onset of dementia relative to parkinsonism: dementia occurring within the first year following the onset of parkinsonism is diagnosed as DLB [96,97]. Here, we focus primarily on DLB, as pain in Parkinson's has been reviewed elsewhere [1,2,98,99].…”

Section: Pain In Dementia With Lewy Bodiesmentioning

confidence: 99%

Pain in neurodegenerative diseases with atypical parkinsonis a systematic review on prevalence, clinical presentation, and findings from experimental studies

Chang¹,

Rukavina²,

Lawn³

2021

Journal of Integrative Neuroscience

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Parkinson's disease-related pain has increasingly been investigated in research studies. Still, only a few studies have addressed the prevalence and clinical characteristics of pain in neurodegenerative disorders with atypical parkinsonism. The existing evidence, although scarce, suggests that, similarly as in Parkinson's disease, individuals with neurodegenerative diseases with atypical parkinsonism might be predisposed to the development of persistent pain. Today, as the global population is aging and we face an epidemic of neurodegenerative disorders, under-treated pain is taking a great toll on an everrising number of people. Here, we provide an up-to-date review of the current knowledge on the prevalence of pain, its clinical features, and findings from experimental studies that might signpost altered pain processing in the most prevalent neurodegenerative disorders with atypical parkinsonism: multiple system atrophy, progressive supranuclear palsy, corticobasal syndrome, frontotemporal dementia, and dementia with Lewy bodies. Finally, we point out the current gaps and unmet needs that future research studies should focus on. Large-scale, high-quality clinical trials, coupled with pre-clinical research, are urgently needed to reveal the exact pathophysiological mechanisms underpinning heightened pain and pave the path for mechanistically-driven analgesic interventions to be developed, ultimately leading to an improvement in the quality of life of individuals with neurodegenerative disorders.

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Section: Pain In Dementia With Lewy Bodiesmentioning

confidence: 99%

Pain in neurodegenerative diseases with atypical parkinsonis a systematic review on prevalence, clinical presentation, and findings from experimental studies

Chang¹,

Rukavina²,

Lawn³

2021

Journal of Integrative Neuroscience

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“…Chronic pain, present in over 80% People with Parkinson's disease (PD, PwP), is a challenging non-motor symptom (NMS), adversely affecting the health-related quality of life. [1][2][3] In individuals from ethnic minorities, a distinctive non-motor dominant clinical phenotype of PD, marked by a greater NMS burden, including heightened pain experience, has been reported. 4 Disparities in diagnosis, treatment and survival of PwP from ethnic minorities, compared to White PD patients, exist.…”

Section: Resultsmentioning

confidence: 99%

“…Conclusions Conclusions: Ethnic disparities in the analgesic use among PwP with chronic pain living in the UK are evident in this retrospective analysis, prompting large-scale studies and reinforcement of interventions to tackle the impact ethnicity might have on the successful analgesia.Chronic pain, present in over 80% People with Parkinson's disease (PD, PwP), is a challenging non-motor symptom (NMS), adversely affecting the health-related quality of life. [1][2][3] In individuals from ethnic minorities, a distinctive non-motor dominant clinical phenotype of PD, marked by a greater NMS burden, including heightened pain experience, has been reported. 4 Disparities in diagnosis, treatment and survival of PwP from ethnic minorities, compared to White PD patients, exist.…”

mentioning

confidence: 99%

Ethnic Disparities in Treatment of Chronic Pain in Individuals with Parkinson's Disease Living in the United Kingdom

Rukavina

Ocloo

Skorić

et al. 2022

Movement Disord Clin Pract

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Background Over 80% people with Parkinson's disease (PD; PwP) live with chronic pain. Objective Whether ethnic disparities in receipt of appropriate analgesia exist among PwP with chronic pain living in the United Kingdom (UK). Methods A retrospective datamining of an existing King's PD Pain Questionnaire validation study dataset enrolling 300 PwP. Results 69 PwP: 23 Black (57% female), 23 Asian (57% female) and 23 White (65% female) had similar pain burden on the King's PD Pain Scale. Significantly more White PwP (83%) received pain relief compared to Black (48%) and Asian (43%) PwP (p = 0.016). The difference was most evident for opioid analgesics (White 43% vs. Black 4% vs. Asian 4%, p ≤ 0.001). Conclusions Ethnic disparities in the analgesic use among PwP with chronic pain living in the UK are evident in this retrospective analysis, prompting large‐scale studies and reinforcement of interventions to tackle the impact ethnicity might have on the successful analgesia.

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“…Studies formally characterizing sensory function in different Alzheimer’s disease mouse models are not abundant (Reviewed by Lawn et al, 2021 ). In our hands, sensory evaluations did not yield a distinct functional difference between 5XFAD and wild-type animals.…”

Section: Discussionmentioning

confidence: 99%

Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation

Uddin

Arakawa

Raver

et al. 2021

Neurobiology of Pain

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Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease

Cited by 26 publications

References 158 publications

Pain in neurodegenerative diseases with atypical parkinsonis a systematic review on prevalence, clinical presentation, and findings from experimental studies

Pain in neurodegenerative diseases with atypical parkinsonis a systematic review on prevalence, clinical presentation, and findings from experimental studies

Ethnic Disparities in Treatment of Chronic Pain in Individuals with Parkinson's Disease Living in the United Kingdom

Patterns of cognitive decline and somatosensory processing in a mouse model of amyloid accumulation

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