Pain in Rheumatoid Arthritis: Models and Mechanisms

Baş, Duygu B.; Su, Jie; Wigerblad, Gustaf; Svensson, Camilla I.

doi:10.2217/pmt.16.4

Cited by 60 publications

(57 citation statements)

References 135 publications

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“…CIA mice display decreased climbing, locomotion and grooming behaviours [73], thermal hypersensitivity [73,83], and mechanical hypersensitivity, which develops prior to inflammation [11,12] and lasts for at least 28 days following arthritis-onset [73].…”

Section: Immunization Modelsmentioning

confidence: 99%

“…In both models development of mechanical hypersensitivity precedes inflammation, is maintained during inflammation and persists for several weeks after the resolution of joint inflammation [3,10,17,19,29,31,165]. In addition, mice display thermal hypersensitivity [10,11,29,30] and reduced locomotor activity [19,150,158,166] Although not yet an established model of RA, transfer of ACPA IgG isolated from patients or patient B-cell derived murinized monoclonal ACPA to naïve mice leads to mechanical and thermal hypersensitivity, decreased locomotor activity and bone erosion in the absence of joint inflammation or sickness [92,180]. The pain-like behavior develops within 3-7 days and lasts up to 28 days post injection.…”

Section: Transfer Modelsmentioning

confidence: 99%

“…Comprehensive reviews of mechanisms focusing on particular cell types (i.e. glia) [11] and on RA inflammation and joint destruction can be found elsewhere [13,88,113].…”

Section: Mechanismsmentioning

confidence: 99%

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Pain pathogenesis in rheumatoid arthritis—what have we learned from animal models?

Krock

Jurczak²,

Svensson³

2018

Pain

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Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as pain, will disappear. However, pain is the most common complaint of RA patients, is often still present following the resolution of inflammation, and can develop prior to the onset of inflammation. Thus, further research is needed to better understand RA-associated pain mechanisms. A number of preclinical rodent models commonly used in rheumatology research have been developed based on bedside-to-bench and reverse translational approaches. These models include collagen-induced arthritis, antigen-induced arthritis, streptococcal

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Section: Immunization Modelsmentioning

confidence: 99%

Section: Transfer Modelsmentioning

confidence: 99%

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Pain pathogenesis in rheumatoid arthritis—what have we learned from animal models?

Krock

Jurczak²,

Svensson³

2018

Pain

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“…Although animal models of arthritis have been widely utilized for decades to study not just disease pathogenesis and candidate therapeutics, only in the past 10–15 years have the biological properties of pain in these systems begun to be investigated systematically [46, 47]. …”

Section: Introductionmentioning

confidence: 99%

“…In addition, age may be an additional variable, because adjuvant-induced arthritis evoked similar inflammatory responses in young and old mice, but induced higher levels of mechanical hypersensitivity in younger mice using the von Frey test [48]. These discordances aside, sensitization of pain pathways is typically concomitant with the appearance of clinical signs of inflammation, and in some cases it can precede them [46, 49]. This is consistent with pain often being the earliest disease manifestation in human RA patients [1, 50].…”

Section: Introductionmentioning

confidence: 99%

Animal models of rheumatoid pain: experimental systems and insights

et al. 2017

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Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of the neuroadaptive mechanisms acting in nociceptors and in the central nervous system in the establishment of chronic and neuropathic pain are still poorly understood, representing an area of intense study and translational priority. Several well-established inducible and spontaneous animal models are available to study the onset, progression and chronicization of inflammatory joint disease, and have been instrumental in elucidating its immunopathogenesis. However, quantitative assessment of pain in animal models is technically and conceptually challenging, and it is only in recent years that inflammatory arthritis models have begun to be utilized systematically in experimental pain studies using behavioral and neurophysiological approaches to characterize acute and chronic pain stages. This article aims primarily to provide clinical and experimental rheumatologists with an overview of current animal models of arthritis pain, and to summarize emerging findings, challenges and unanswered questions in the field.

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Pain in Biologic‐Treated Rheumatoid Arthritis Patients: The Role of Illness Perception Before and After the COVID‐19 Pandemic

Theofanidis,

Timkova,

Macejova

et al. 2024

Musculoskeletal Care

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BackgroundWe aimed to assess the role of the COVID‐19 pandemic in the association of clinical, physical, and psychological factors with pain in Rheumatoid Arthritis (RA) patients.MethodsWe included 103 RA patients (81.6% females; mean age 56.1 ± 13.8 years). Patients filled out the VAS‐pain, GAD‐7, PHQ‐9, MFI‐20, and B‐IPQ. Paired sample t‐tests, correlations, and multiple regression analyses were used to analyse the data.ResultsOur results showed significantly worsened pain in the data collected post‐pandemic (p ≤ 0.05). Pre‐pandemic, the final regression models showed an association between functional disability (β = 0.24; p ≤ 0.05), illness perception (β = 0.34; p ≤ 0.05) and pain. In post‐pandemic models, significant associations were found between fatigue (β = 0.33; p ≤ 0.01) and illness perception (β = 0.36; p ≤ 0.01) with pain. Positive illness perception was able to alleviate the associations between fatigue and depression with pain before and after the pandemic.ConclusionFindings indicate that patients with RA may have been negatively affected by the COVID‐19 pandemic given their vulnerability. Even though pharmacological treatment was not interrupted, post‐pandemic results showed significantly higher levels of experienced pain. Therefore, in addition to biological therapy, non‐pharmacological interventions, including psychological support aimed at diminishing negative illness perception, may be beneficial in reducing RA‐related pain, especially when dealing with a crisis.

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Pain in Rheumatoid Arthritis: Models and Mechanisms

Cited by 60 publications

References 135 publications

Pain pathogenesis in rheumatoid arthritis—what have we learned from animal models?

Pain pathogenesis in rheumatoid arthritis—what have we learned from animal models?

Animal models of rheumatoid pain: experimental systems and insights

Pain in Biologic‐Treated Rheumatoid Arthritis Patients: The Role of Illness Perception Before and After the COVID‐19 Pandemic

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