Pain in malignant hematology

Niscola, Pasquale; Tendas, Andrea; Scaramucci, Laura; Giovaninni, Marco; Cupelli, Luca; Sanctis, Vitaliana De; Brunetti, Gregorio Antonio; Bondanini, Francesco; Palumbo, Roberto; Lamanda, Michela; Battistini, Roberta; Cartoni, Claudio; Romani, Claudio; Arcuri, Edoardo

doi:10.1586/ehm.10.79

Cited by 26 publications

(16 citation statements)

References 81 publications

(153 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study of 464 patients affected by hematological cancer revealed 284 different pain syndromes in this group, with 56% diagnosed as deep somatic, 15% as superficial somatic, 14% as visceral, 7% as neuropathic, and 8% mixed. In Table 2 are reported the most common pain syndromes in patients with hematological malignancies [26,27].…”

Section: Clinical Presentation and Assessment Of Painmentioning

confidence: 99%

Cancer Pain Assessment and Classification

Caraceni

Shkodra

2019

Cancers

163

130

View full text Add to dashboard Cite

More than half of patients affected by cancer experience pain of moderate-to-severe intensity, often in multiple sites, and of different etiologies and underlying mechanisms. The heterogeneity of pain mechanisms is expressed with the fluctuating nature of cancer pain intensity and clinical characteristics. Traditional ways of classifying pain in the cancer population include distinguishing pain etiology, clinical characteristics related to pain and the patient, pathophysiology, and the use of already validated classification systems. Concepts like breakthrough, nociceptive, neuropathic, and mixed pain are very important in the assessment of pain in this population of patients. When dealing with patients affected by cancer pain it is also very important to be familiar to the characteristics of specific pain syndromes that are usually encountered. In this article we review methods presently applied for classifying cancer pain highlighting the importance of an accurate clinical evaluation in providing adequate analgesia to patients.

show abstract

Section: Clinical Presentation and Assessment Of Painmentioning

confidence: 99%

Cancer Pain Assessment and Classification

Caraceni

Shkodra

2019

Cancers

163

130

View full text Add to dashboard Cite

show abstract

“…Bone pain is a common and severe symptom in cancer patients, especially in advanced stage ( Jimenez-Andrade et al, 2010 ; Kane, Hoskin & Bennett, 2015 ; Mantyh, 2014 ; Mantyh & Hunt, 2004 ). Many patients with hematological malignancies (leukemia, lymphoma, myeloma, myelodysplastic syndromes and myeloproliferative neoplasms) frequently experience pain ( Niscola et al, 2011 ). Currently the molecular mechanisms underlying leukemia bone pain are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Analgesic effects of lappaconitine in leukemia bone pain in a mouse model

Zhu

Wang

et al. 2015

PeerJ

View full text Add to dashboard Cite

Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results showed that the lappaconitine treatment at day 15, 17 and 19 could effectively reduce the spontaneous pain scoring values, restore reduced degree in the inclined-plate test induced by injection of K562 cells, as well as restore paw mechanical withdrawal threshold and paw withdrawal thermal latency induced by injection of K562 cells to the normal levels. Additionally, the molecular mechanisms of lappaconitine’s analgesic effects may be related to affect the expression levels of endogenous opioid system genes (POMC, PENK and MOR), as well as apoptosis-related genes (Xiap, Smac, Bim, NF-κB and p53). Our present results indicated that lappaconitine may become a new analgesic agent for leukemia bone pain management.

show abstract

“…Moreover, we observed that somatic pain was most frequently associated with leukemias, while visceral pain was most frequently associated with lymphomas (P value < 0.0005) ( Figure 4,8 & Table 1). Another study, dealing with the pain experienced by hospitalized hematologic malignancy adult patients, visceral pain was mostly observed in non-Hodgkin lymphomas [20,21].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

JCPCR

View full text Add to dashboard Cite

Background: Cancer in children is a potentially curable disease, particularly in developed countries. Conventional chemotherapy is essentially an integral part of treatment, either alone, or as a part of multimodality therapy including surgery & radiotherapy. How to deal with pain is an integral part of symptom management in pediatric cancer patients in general, with especially great importance in the context of palliative care in developing countries, in which curability lags behind that of developed countries. Proper recognition of underlying pathophysiology and various causes of pain are so essential for pain management, and for ameliorating suffering in the realm of holistic care for children with cancer. The aim of this study is to address and meticulously analyze the spectrum of pain characteristics in children with cancer at an institutional university cancer center to unravel pain profile in these patients as an experience for a developing country. Patients & Methods: A hospital based, prospective study was conducted, involving pediatric cancer patients, who presented with pain due to cancer itself or its treatment in the period from 2013 Jul to 2015 Jan. Evaluation of patients' documented pain cycles for pain cause, type, and location & also for pain treatment characteristics was done. Results: A total of 286 pain cycles was documented comprising 2216 treatment days (range 3-56 days). Disease-related pain was the most frequent cause of pain in our study. Oral mucosa was the most frequent site for treatment-related pain & strongly correlated with NHL diagnosis. Leukemia was strongly correlated with "the extremities" as a location of bone pain. Visceral pain was most often associated with lymphomas. Neuropathic pain was the least frequent type of pain, however, associated with higher initial pain intensity scores & longer pain cycle duration. Conclusion: Children with cancer in the developing countries still have more disease-related pain than their counterparts in the developed countries. Pain experience in pediatric oncology may indirectly reflect presentations of childhood cancer, and could be a surrogate profile for tumor location, metastatic sites, the degree of treatment intensity, likewise the context of the disease state either at diagnosis, during treatment, or at progression.

show abstract

Pain in malignant hematology

Cited by 26 publications

References 81 publications

Cancer Pain Assessment and Classification

Cancer Pain Assessment and Classification

Analgesic effects of lappaconitine in leukemia bone pain in a mouse model

Untitled

Contact Info

Product

Resources

About