Pain in hereditary neuropathy with liability to pressure palsy: An association with fibromyalgia syndrome?

Yılmaz, Uğur; Bird, Thomas T.; Carter, Gregory T.; Wang, Leo H.; Weiss, Michael D.

doi:10.1002/mus.24331

Cited by 20 publications

(23 citation statements)

References 23 publications

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“…Pain is rarely reported in HNPP 2,16 and is considered a very uncommon in the acute episodes of nerve paralysis 2 , but may be the initial manifestation of the disease 17 or a chronic component of this neuropathy 18,19 . Interestingly, it has been recently described a HNPP family due to a point mutation, whose main manifestations were pain and paresthesias, without recurrent palsies 18 .…”

Section: Discussionmentioning

confidence: 99%

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Clinical and neurophysiological features of the hereditary neuropathy with liability to pressure palsy due to the 17p11.2 deletion

Oliveira

Pereira

Onofre

et al. 2016

Arq. Neuro-Psiquiatr.

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The hereditary neuropathy with liability to pressure palsies (HNPP) is an autossomal dominant disorder manifesting recurrent mononeuropathies. Objective Evaluate its clinical and nerve conduction studies (NCS) characteristics, searching for diagnostic particularities. Method We reviewed the neurological manifestations of 39 and the NCS of 33 patients. Results Family history was absent in 16/39 (41%). The onset complaints were weakness in 24, pain in 6, sensory deficit in 5 and paresthesias in 4. Pain was seen in 3 other patients. The following neuropathy patterns were found: multiple mononeuropathy (26), mononeuropathy (7), chronic sensorimotor polyneuropathy (4), chronic sensory polyneuropathy (1) and unilateral brachial plexopathy (1). NCS showed a sensorimotor neuropathy with focal conduction slowing in 31, two had mononeuropathy and another brachial plexopathy. Conclusion HNPP presentation is variable and may include pain. The most frequent pattern is of an asymmetrical sensory and motor neuropathy with focal slowing at specific topographies on NCS.

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Section: Discussionmentioning

confidence: 99%

“…Pain was considered rare 2,16 , but recent studies described pain in patients with upper limbs mononeuropathies 17,18 and occasionally neuropathic pain may be found 17 . Some patients present musculoskeletal pain that meet the fibromyalgia criteria, potentially delaying diagnosis 19 .…”

mentioning

confidence: 99%

Clinical and neurophysiological features of the hereditary neuropathy with liability to pressure palsy due to the 17p11.2 deletion

Oliveira

Pereira

Onofre

et al. 2016

Arq. Neuro-Psiquiatr.

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show abstract

“…The pain in these nine individuals was deemed neuropathic, seemingly based on clinical presentation. Another retrospective review of 32 people with genetic confirmation of HNPP provided a more detailed characterisation of pain [30]. Twenty four (75%) people reported pain.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of pain in people with hereditary neuropathy with liability to pressure palsy

et al. 2017

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Hereditary neuropathy with liability to pressure palsy (HNPP) has historically been considered a pain-free condition, though some people with HNPP also complain of pain. This study characterised persistent pain in people with HNPP. Participants provided cross-sectional demographic data, information on the presence of neurological and persistent pain symptoms, and the degree to which these interfered with daily life. The painDETECT and Central Sensitization Inventory questionnaires were used to indicate potential neuropathic, central sensitisation and musculoskeletal (nociceptive) pain mechanisms. Additionally, participants were asked if they thought that pain was related to/part of HNPP. 32/43 (74%) subjects with HNPP had persistent pain and experience this pain in the last week. Of those with pain, 24 (75%) were likely to have neuropathic pain and 27 (84%) were likely to have central sensitisation. All 32 participants felt that their pain could be related to/part of their HNPP. Significant negative impact of the pain was common. Pain characterisation identified neuropathic pain and/or central sensitisation as common, potential underlying processes. Pain may plausibly be directly related to the underlying pathophysiology of HNPP. Further consideration of including pain as a primary symptom of HNPP is warranted.

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“…10,11 However, there have been reports of both neuropathic and musculoskeletal pain related to HNPP. 8 Symptoms of pain may precede the more classic symptoms of transient paresthesias or weakness in HNPP. Of note, diagnosis may be delayed in patients who present with pain.…”

mentioning

confidence: 99%

“…Of note, diagnosis may be delayed in patients who present with pain. 8 Moreover, absence of family history should not preclude the diagnosis of HNPP. Approximately 20% of HNPP cases are sporadic due to de novo mutations in PMP22.…”

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confidence: 99%

Sleep palsy involving different nerves: Role of ultrasound

et al. 2016

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Pain in hereditary neuropathy with liability to pressure palsy: An association with fibromyalgia syndrome?

Abstract: Neuropathic and musculoskeletal pain occur commonly in HNPP and may be a presenting symptom. Additionally, HNPP with predominantly musculoskeletal pain may meet criteria for FMS and potentially delay the diagnosis.

Cited by 20 publications

References 23 publications

Clinical and neurophysiological features of the hereditary neuropathy with liability to pressure palsy due to the 17p11.2 deletion

Clinical and neurophysiological features of the hereditary neuropathy with liability to pressure palsy due to the 17p11.2 deletion

Characterisation of pain in people with hereditary neuropathy with liability to pressure palsy

Sleep palsy involving different nerves: Role of ultrasound

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