Pain in amyotrophic lateral sclerosis: a population‐based controlled study

Chiò, Adriano; Canosa, Antonio; Gallo, Silvia; Moglia, Cristina; Ilardi, Antonio; Cammarosano, Stefania; Papurello, D.; Calvo, Andrea

doi:10.1111/j.1468-1331.2011.03540.x

Cited by 87 publications

(121 citation statements)

References 23 publications

(36 reference statements)

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“…Pain in our series was, on average, moderate in intensity, but was severe in some patients, and a barrier to daily life activities. Similar findings have been observed by others (2,3,6) and by us in a previous series of patients recruited by a different method (23). Importantly, relief as a result of pain treatments was not impressive, averaging less than 50% (100% ¼ complete relief).…”

Section: Discussionsupporting

confidence: 74%

“…Nearly a quarter of the sample experienced no pain relief, and this is a major concern. Others have found that the use of opioids is common, yet those same series demonstrate significant average pain (2,3,6). It is unknown whether the poor pain control is due to lack of adequate assessment of pain by the health care team, ineffective treatments, or other causes, but it certainly is meaningful that almost 30% of our study patients were not receiving any treatment for their pain.…”

Section: Discussionmentioning

confidence: 80%

“…It is experienced in all stages of the disease, and has a moderately severe impact on patients' daily activities (1)(2)(3)(4)(5)(6). Many factors contribute to pain in these patients, including muscle atrophy, damage to connective tissue, increased strain on joints, joint contractures and discomfort from pressure due to limited mobility, and muscle cramps and spasms (4).…”

Section: Introductionmentioning

confidence: 99%

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The role of mental health and self-efficacy in the pain experience of patients with amyotrophic lateral sclerosis

Stephens

Lehman

Raheja

et al. 2016

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Complex interactions between pain, depression, and anxiety impact quality of life in patients with ALS. Psychological approaches to pain control may be useful. This study explored the role of self-efficacy in mitigating pain. Individuals registered with the Agency for Toxic Substances and Disease Registry National ALS Registry and who experienced pain were invited to participate in an online survey. Subjects completed the Brief Pain Inventory-Short Form, Hospital Anxiety and Depression Scale, and Chronic Pain Self-Efficacy Scale. Correlations between variables were determined. Multiple linear regression models assessed relationships between depression, anxiety and self-efficacy predictions, and pain severity, interference, and relief. Results recorded that there were 197 participants (58% males, mean age 59 AE 10 years). Cases or borderline cases of depression or anxiety were common. Mean levels of pain were moderate. Higher pain self-efficacy scores predicted lower pain severity, lower pain interference, and higher pain relief with treatment. As depression scores increased, pain interference with daily life was higher. In conclusion, anxiety and depression are common in patients with ALS and pain. Self-efficacy appears to mitigate pain. A multifactorial approach to pain management should be considered in these patients, addressing mental health and self-efficacy to augment pharmacologic pain treatments.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The role of mental health and self-efficacy in the pain experience of patients with amyotrophic lateral sclerosis

Stephens

Lehman

Raheja

et al. 2016

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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“…The most often reported locations are the upper and lower extremities, shoulders, and hips 9 . Odynophagia is perceived as pain evoked during swallowing 10 .…”

mentioning

confidence: 99%

Higher risk of complications in odynophagia-associated dysphagia in amyotrophic lateral sclerosis

Luchesi

Kitamura

Mourão

2014

Arq. Neuro-Psiquiatr.

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Objective: This investigation aimed to identify associated factors with dysphagia severity in amyotrophic lateral sclerosis (ALS). Method: We performed a cross-sectional study of 49 patients with ALS. All patients underwent fiberoptic endoscopy evaluation of swallowing and answered a verbal questionnaire about swallowing complaints. The patients were divided into groups according to dysphagia severity. Results: Among the factors analyzed, only odynophagia was associated with moderate or severe dysphagia. Conclusion: Odynophagia was associated with moderate and severe dysphagia in ALS and suggests a high risk of pulmonary and nutritional complications.Keywords: amyotrophic lateral sclerosis, dysphagia, neurodegenerative disorders, malnutrition, pneumonia, pain. RESUMOObjetivo: Identificar fatores associados com a gravidade da disfagia na esclerose lateral amiotrófica (ELA). Método: Estudo transversal incluindo 49 sujeitos com esclerose lateral amiotrófica. Todos foram submetidos à videoendoscopia da deglutição e responderam a um questionário sobre queixas de deglutição. Foram divididos em grupos de acordo com a gravidade da disfagia. Resultados: Dentre os fatores estudados, apenas a odinofagia foi significantemente associada à disfagia moderada ou grave. Conclusão: A odinofagia foi associada à disfagia moderada ou grave na ELA e sua presença sugere maior risco para complicações pulmonares e nutricionais.Palavras-chave: esclerose lateral amiotrófica, disfagia, doenças neurodegenerativas, desnutrição, pneumonia, dor.

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“…11 However, many articles pointed out that pain in ALS or MND has under-recognized and underestimated. 12,13 This study focused on end-of-life care involving the use of NIV. The aim of this study was to clarify the aspects of pain experienced by patients with ALS receiving NIV at end-of-life.…”

Section: Introductionmentioning

confidence: 99%

Pain at end-of-life among patients with amyotrophic lateral sclerosis receiving noninvasive ventilation

Ushikubo

2017

IJND

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Abstract:The purpose of this study was to clarify aspects of pain before death among patients with amyotrophic lateral sclerosis (ALS) receiving noninvasive positive pressure ventilation (NPPV).The participant in this study was anexcellent nurse manager. We conducted a semi-structured interview regarding three ALS patients who had been receiving NPPV during the last month before death. Data were analyzed using inductive qualitative analysis. The deceased ALS patients who had been receiving NPPV were two males and one female ranging in age between their 60s and 70s. The period from onset of ALS to death ranged from 18-31 months. The duration of NPPV use ranged from 1.5 months to 2 years. The following seven categories were extracted as aspects of patients' pain: physical pain; anxiety about their children; regrets about life; pain from a bad family relationship; pain from strong pride; pain from fluctuating decision making about medical treatment for respiratory problems; and pain from not being able to express gratitude to others. Nurses and other health care professions should employ the concept of "Total Pain"and a community-integrated approach toprovide palliative care to ALS patients receiving NPPV at end-of-life.

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Pain in amyotrophic lateral sclerosis: a population‐based controlled study

Cited by 87 publications

References 23 publications

The role of mental health and self-efficacy in the pain experience of patients with amyotrophic lateral sclerosis

The role of mental health and self-efficacy in the pain experience of patients with amyotrophic lateral sclerosis

Higher risk of complications in odynophagia-associated dysphagia in amyotrophic lateral sclerosis

Pain at end-of-life among patients with amyotrophic lateral sclerosis receiving noninvasive ventilation

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