Pain Impacts on Quality of Life and Interferes with Treatment in Adults with Cystic Fibrosis

Kelemen, L; Lee, Annemarie L.; Button, Brenda; Presnell, Scott; Wilson, John W.; Holland, Anne E

doi:10.1002/pri.524

Cited by 30 publications

(44 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study, female sex was associated with higher scores in body image and weight scales, and females reported lower physical functioning and vitality scores. 39 However, Shoff et al 40 found no significant sex differences in mean CFQ dimension scores or nutritional status scores in children and adolescents, but the strength of association between nutritional status and CFQ scores differed between boys and girls for some dimensions, such as physical functioning. In the present study, the 6MWD was an independent predictor for both WHOQOL-BREF and CFQOL scores.…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies showed that pulmonary function in adults with CF is also a significant predictor of CFQOL scores. 38,39 In a longitudinal study, Abbott et al 38 observed that the percent-of-predicted FEV 1 significantly correlated with all domains except body image. In contrast, in the present study, the percent-of-predicted FEV 1 showed an association only with the social relationship domain in the WHOQOL-BREF questionnaire and the respiratory symptom domain in the CFQOL questionnaire.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Clinical Variables and Health-Related Quality of Life in Young Adult Subjects With Cystic Fibrosis

Forte

Perin

et al. 2015

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Health-related quality of life (HRQOL) has received much attention in patients with cystic fibrosis (CF). The goal of this study was to evaluate the association between clinical, lung function, sleep quality, and polysomnographic variables with 2 HRQOL questionnaires, the shorterversion World Health Organization Quality of Life (WHOQOL-BREF) and Cystic Fibrosis Quality of Life (CFQOL) questionnaires, in adult subjects with CF. METHODS: In a cross-sectional study, 51 subjects underwent clinical evaluation and overnight polysomnography and answered WHO-QOL-BREF, CFQOL, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale questionnaires. In addition, pulmonary function tests, 6-min walk tests, and echocardiography were performed. RESULTS: For WHOQOL-BREF scores, the sleep quality index was associated with the physical domain; the percent-of-predicted 6-min walk distance (6MWD) and sleepiness scale were associated with the psychological domain; the percent-of-predicted FEV 1 and sleep quality index were associated with the social relationship domain; and the sleep quality index was associated with the environment domain. For CFQOL scores, age at diagnosis, clinical score, and sleep quality index were associated with the physical functioning domain; the percent-of-predicted 6MWD and pulmonary arterial systolic pressure were associated with the role domain; sex and sleep quality index were associated with the vitality domain; the apnea-hypopnea index was associated with the emotional functioning domain; sex and body mass index (BMI) were associated with the body image domain; the percent-of-predicted 6MWD and sleep quality index were associated with the health perception domain; age, sex, BMI, and arousal index were associated with the weight domain; age, sex, percent-of-predicted FEV 1 , percent-of-predicted 6MWD, and pulmonary arterial systolic pressure were associated with the respiratory symptom domain; and the clinical score was associated with the digestive symptom domain. CONCLUSIONS: The sleep quality index score, 6MWD, sleepiness scale score, and FEV 1 were predictors of WHOQOL-BREF scores. Age at diagnosis, clinical score, sleep quality score, 6MWD, sex, apnea-hypopnea index, BMI, current age, arousal index, FEV 1 , and pulmonary arterial systolic pressure were predictors of CFQOL scores.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Relationship Between Clinical Variables and Health-Related Quality of Life in Young Adult Subjects With Cystic Fibrosis

Forte

Perin

et al. 2015

Respir Care

View full text Add to dashboard Cite

show abstract

“…Consequently, greater attention is being paid to patients’ quality of life (QOL). CF patients frequently complain of pain, mainly back pain, chest pain and headache [4]–[11]. Although pain in adults with CF is associated with lower QOL [5]–[6], [11], increased risk of exacerbation [6] and decreased survival [6], [12], it is often neglected by the treating physicians [5], [8].…”

Section: Introductionmentioning

confidence: 99%

“…CF patients frequently complain of pain, mainly back pain, chest pain and headache [4]–[11]. Although pain in adults with CF is associated with lower QOL [5]–[6], [11], increased risk of exacerbation [6] and decreased survival [6], [12], it is often neglected by the treating physicians [5], [8]. In addition to drug treatment, many patients with CF use non-drug treatments and complementary and alternative medicine (CAM) [5]–[6], [8], [13]–[15] including osteopathic manipulative treatment (OMT).…”

Section: Introductionmentioning

confidence: 99%

Impact of Osteopathic Treatment on Pain in Adult Patients with Cystic Fibrosis – A Pilot Randomized Controlled Study

et al. 2014

View full text Add to dashboard Cite

BackgroundPain is a common complication in patients with cystic fibrosis (CF) and is associated with shorter survival. We evaluated the impact of osteopathic manipulative treatment (OMT) on pain in adults with CF.MethodsA pilot multicenter randomized controlled trial was conducted with three parallel arms: OMT (group A, 16 patients), sham OMT (sham treatment, group B, 8 patients) and no treatment (group C, 8 patients). Medical investigators and patients were double-blind to treatment for groups A and B, who received OMT or sham OMT monthly for 6 months. Pain was rated as a composite of its intensity and duration over the previous month. The evolution of chest/back pain after 6 months was compared between group A and groups B+C combined (control group). The evolution of cervical pain, headache and quality of life (QOL) were similarly evaluated.ResultsThere was no statistically significant difference between the treatment and control groups in the decrease of chest/back pain (difference = −2.20 IC95% [−4.81; 0.42], p = 0.098); also, group A did not differ from group B. However, chest/back pain decreased more in groups A (p = 0.002) and B (p = 0.006) than in group C. Cervical pain, headache and QOL scores did not differ between the treatment and control groups.ConclusionThis pilot study demonstrated the feasibility of evaluating the efficacy of OMT to treat the pain of patients with CF. The lack of difference between the group treated with OMT and the control group may be due to the small number of patients included in this trial, which also precludes any definitive conclusion about the greater decrease of pain in patients receiving OMT or sham OMT than in those with no intervention.Trial RegistrationClinicalTrials.gov NCT01293019

show abstract

“…Advances in the treatment have improved the life expectancy of people with CF [2]. The increased longevity of adults with CF is accompanied by a rising prevalence of secondary complications including pain [3], which can be associated with the diagnosis and treatment of the disease, and the disease itself [4].…”

mentioning

confidence: 99%

Hypovitaminosis D and Pain in Cystic Fibrosis

Mascitelli¹,

Goldstein

Grant

2012

Pain Med

View full text Add to dashboard Cite

Pain Impacts on Quality of Life and Interferes with Treatment in Adults with Cystic Fibrosis

Abstract: Pain is common in adults with CF, irrespective of clinical status, and may interfere with important physiotherapy treatments. Although pain intensity is generally mild, those with a negative emotional response to pain have significantly impaired HRQOL.

Cited by 30 publications

References 43 publications

Relationship Between Clinical Variables and Health-Related Quality of Life in Young Adult Subjects With Cystic Fibrosis

Relationship Between Clinical Variables and Health-Related Quality of Life in Young Adult Subjects With Cystic Fibrosis

Impact of Osteopathic Treatment on Pain in Adult Patients with Cystic Fibrosis – A Pilot Randomized Controlled Study

Hypovitaminosis D and Pain in Cystic Fibrosis

Contact Info

Product

Resources

About