Pain exacerbation as a major source of lost productive time in US workers with arthritis

Ricci, Judith A.; Stewart, Walter F.; Chee, Elsbeth; Leotta, Carol; Foley, Kathleen A.; Hochberg, Marc C.

doi:10.1002/art.21453

Cited by 106 publications

(67 citation statements)

References 14 publications

(18 reference statements)

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“…Pain is a most important symptom in arthritic patients, frequently leading to loss of function (45). Previous studies (27,46) have clearly shown an essential role for neutrophils in mediating inflammatory-related hypernociception in mice subjected to AIA.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis

Sachs¹

2010

The Journal of Immunology

156

107

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Activation of the renin-angiotensin (Ang) system induces inflammation via interaction between Ang II and type 1 receptor on leukocytes. The relevance of the new arm of the renin-Ang system, namely Ang-converting enzyme-2/Ang-(1–7)/Mas receptor, for inflammatory responses is not known and was investigated in this study. For this purpose, two experimental models were used: Ag-induced arthritis (AIA) in mice and adjuvant-induced arthritis (AdIA) in rats. Male C57BL/6 wild-type or Mas−/− mice were subjected to AIA and treated with Ang-(1–7), the Mas agonist AVE 0991, or vehicle. AdIA was performed in female rats that were given AVE 0991 or vehicle. In wild-type mice, Mas protein is expressed in arthritic joints. Administration of AVE 0991 or Ang-(1–7) decreased AIA-induced neutrophil accumulation, hypernociception, and production of TNF-α, IL-1β, and CXCL1. Histopathological analysis showed significant reduction of inflammation. Mechanistically, AVE 0991 reduced leukocyte rolling and adhesion, even when given after Ag challenge. Mas−/− mice subjected to AIA developed slightly more pronounced inflammation, as observed by greater neutrophil accumulation and cytokine release. Administration of AVE 0991 was without effect in Mas−/− mice subjected to AIA. In rats, administration of AVE 0991 decreased edema, neutrophil accumulation, histopathological score, and production of IL-1β and CXCL1 induced by AdIA. Therefore, activation of Mas receptors decreases neutrophil influx and cytokine production and causes significant amelioration of arthritis in experimental models of arthritis in rats and mice. This approach might represent a novel therapeutic opportunity for arthritis.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis

Sachs¹

2010

The Journal of Immunology

156

107

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“…OA has been found to have average direct yearly costs between $2,650 and $5,700 per person (3,4). More than half of the societal costs of OA are lost productive work time, which has been estimated at $7.1 billion (5,6).…”

Section: Introductionmentioning

confidence: 99%

The incidence of primary hip osteoarthritis in active duty US military servicemembers

Scher

Belmont

Mountcastle

et al. 2009

Arthritis & Rheumatism

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Objective. Although multiple studies have reported the prevalence of primary hip osteoarthritis (OA), little has been reported on incidence rates of hip OA. We sought to determine the incidence rate and demographic risk factors of hip OA in an ethnically diverse and physically active population of US military servicemembers. Methods. A query was performed using the US Defense Medical Epidemiology Database for the International Classification of Diseases, Ninth Revision, Clinical Modification code for hip OA (715.95). Multivariate Poisson regression analysis was used to estimate the rate of hip OA per 100,000 person-years, controlling for sex, race, age, rank, and service. Results. The overall unadjusted incidence rate of hip OA was 35 per 100,000 person-years. Women, compared with men, had a significantly increased adjusted incidence rate ratio for hip OA of 1.87 (95% confidence interval [95% CI] 1.73-2.01). The adjusted incidence rate ratio for black servicemembers when compared with white servicemembers was 1.32 (95% CI 1.23-1.41). The adjusted incidence rate ratio for the >40-year-old age group compared with the 20-year-old group was 22.21 (95% CI 17.54 -28.14). With junior officers as the referent category, junior enlisted, senior enlisted, and senior officers rank groups had a significantly increased adjusted incidence rate ratio for hip OA. With the Air Force as the referent category, each service had a significantly increased adjusted incidence rate ratio for hip OA. Conclusion. Female sex; black race; age >40 years; junior enlisted, senior enlisted, and senior officer rank groups; and military service in the Navy, Army, or Marines were all risk factors for hip OA.

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“…Disease exacerbations and pain control are also related to work loss. Almost one fourth of workers with arthritis currently experiencing a pain exacerbation reported lost productive time from work, compared to 13.1% with arthritis who were not experiencing a pain exacerbation (Ricci et al 2005). …”

Section: Frameworkmentioning

confidence: 99%

Cost-Sharing and Productivity

Gibson¹,

Fendrick²,

Chernew³

2012

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A growing body of literature examines the cross price elasticities between different health care services. For example, increasing the patient out of pocket price for some health care services increases the utilization of other health care services. Yet, the literature has generally ignored the connection between cost sharing for health care services and labor market outcomes. This paper examines the direction and magnitude of the reduced form relationship between patient cost-sharing and work loss following methods used to study the impact of cost-sharing and medical spending, finding a positive, quantitatively meaningful association between cost-sharing and hours absent. We find no such association between cost-sharing and the probability of incurring short-term disability days. This suggests that the cross-market ramifications of higher patient cost sharing extend beyond other health care services to include broad labor market outcomes.

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Pain exacerbation as a major source of lost productive time in US workers with arthritis

Abstract: Objective. To estimate the prevalence of arthritis and arthritis pain exacerbations in US workers including impact on functioning and lost productive work time (LPT).

Cited by 106 publications

References 14 publications

Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis

Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis

The incidence of primary hip osteoarthritis in active duty US military servicemembers

Cost-Sharing and Productivity

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