Pain-depression dyad induced by reserpine is relieved by p,p'-methoxyl-diphenyl diselenide in rats

Oliveira, Carla Elena Sartori; Sari, Marcel Henrique Marcondes; Zborowski, Vanessa Angonesi; Prado, Vinicius Costa; Nogueira, Cristina W.; Zeni, Gilson

doi:10.1016/j.ejphar.2016.10.021

Cited by 18 publications

(10 citation statements)

References 51 publications

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“…In addition, antioxidant activity was implicated in at least part of the therapeutic properties of organoselenium compounds [39,40]. This effect was further showed in studies performed with cell culture [41][42][43] and animal species such as rats [44,45], fishes [46], Drosophila melanogaster [47], and Caenorhabditis elegans [48].…”

Section: Discussionmentioning

confidence: 84%

“…Indeed, several antioxidants strongly activate a signaling molecule involved in response to oxidative stress and cell survival termed nuclear factor erythroid 2-related factor 2 (Nrf2) [ 55 ]. For example, supplementation with the antioxidant p,p ′-methoxyl-diphenyl diselenide was implicated in Nrf2 activation in frontal cortex of rats submitted to experimental pain-depression dyad [ 44 ]. 3-Selena-1-dethiacephem and (PhSe) 2 were also involved in Nrf2 pathway activation, contributing for the antioxidant roles of these organoselenium compounds [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

Frizon

Cararo²,

Saba

et al. 2020

Oxidative Medicine and Cellular Longevity

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Herein, we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H2O2) in cultured mouse neurons. First, α-methylene-β-hydroxy esters were prepared as precursors of allylic bromides. A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (3a-f). We next prepared cultures of neurons from 7-day-old mice (n=36). H2O2 (10-5 M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. (PhSe)2 was used as a positive control. It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2′-nonenal, 8-isoprostane), DNA (8-hydroxy-2′-deoxyguanosine), and protein (carbonyl) modification parameters. Finally, catalase and superoxide dismutase activities were also evaluated. Among the compounds, 3b, 3d, and 3f exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)2. These novel aromatic selenocyanates could be promising to be tried in most sophisticated in vitro studies or even at the preclinical level.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

Frizon

Cararo²,

Saba

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…In addition, antioxidant activity was implicated in at least part of therapeutic properties of organoselenium compounds [39][40]. This effect was further showed in studies performed with cell culture [41][42][43] and animal species such as rats [44][45], fishes [46], Drosophila melanogaster [47], and Caenorhabditis elegans [48].…”

Section: Discussionmentioning

confidence: 85%

“…Indeed, several antioxidants strongly activate a signaling molecule involved in response to oxidative stress and cell survival termed nuclear factor erythroid 2-related factor (Nrf2) [55]. For example, supplementation with the antioxidant p,p'-methoxyl-diphenyl diselenide was implicated in Nrf2 activation in frontal cortex of rats submitted to experimental pain-depression dyad [44]. 3-Selena-1-dethiacephem and (PhSe)2 were also involved in Nrf2 pathway activation, contributing for the antioxidant roles of these organoselenium compounds [56,57].…”

Section: Discussionmentioning

confidence: 99%

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

Frizon¹,

Cararo²,

Saba³

et al. 2020

Preprint

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Herein we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H2O2) in cultured mouse neurons. First, α-methylene-β-hydroxy esters were prepared as precursors of allylic bromides. A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (3a-f). We next prepared cultures of neurons from 7-day-old-mice (n = 36). H2O2 (10⁻5 M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds. PhSe)2 was used as positive control. It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2’-nonenal, 8-isoprostane), DNA (8-hydroxy-2’-deoxyguanosine) and protein (carbonyl) modification parameters. Finally, catalase and superoxide dismutase activities were also evaluated. Among the compounds, 3b, 3d and 3f exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)2. These novel aromatic selenocyanates could be promising to be tried in most sophisticated in vitro studies or even at preclinical level.

show abstract

“…Additional data for depression-like behaviors were identified with the Tail Suspension Test (TST) paradigm [49,51,58,66], although results failing to find these effects were also highlighted [72]. Results from Sucrose Preference Test (SPT) and Novelty Suppressed Feeding Test (NSFT) assays remained consistent, such that the model reliably produced depression-like behaviors in animals as elucidated in these assessments [37,53,56,63,66,67,73]. Further investigation into depression-like behavior using the splash test yielded mixed results, with one study reporting reduced grooming behaviors [56], while others did not [53,64].…”

Section: Reserpine Evaluationmentioning

confidence: 98%

The Fibromyalgia Pain Experience: A Scoping Review of the Preclinical Evidence for Replication and Treatment of the Affective and Cognitive Pain Dimensions

Argenbright,

Bertlesman,

Russell

et al. 2024

Biomedicines

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Fibromyalgia is a chronic, widespread pain disorder that is strongly represented across the affective and cognitive dimensions of pain, given that the underlying pathophysiology of the disorder is yet to be identified. These affective and cognitive deficits are crucial to understanding and treating the fibromyalgia pain experience as a whole but replicating this multidimensionality on a preclinical level is challenging. To understand the underlying mechanisms, animal models are used. In this scoping review, we evaluate the current primary animal models of fibromyalgia regarding their translational relevance within the affective and cognitive pain realms, as well as summarize treatments that have been identified preclinically for attenuating these deficits.

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Pain-depression dyad induced by reserpine is relieved by p,p'-methoxyl-diphenyl diselenide in rats

Cited by 18 publications

References 51 publications

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress

The Fibromyalgia Pain Experience: A Scoping Review of the Preclinical Evidence for Replication and Treatment of the Affective and Cognitive Pain Dimensions

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