Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review

Campanella, Edoardo; Marino, Andrea; Ceccarelli, Manuela; Gussio, Maria; Cosentino, Federica; Moscatt, Vittoria; Micali, Cristina; Nunnari, Giuseppe; Celesia, Benedetto Maurizio; Cacopardo, Bruno

doi:10.3892/wasj.2022.149

Cited by 5 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Direct viral invasion is a primary suspect, where SARS-CoV-2 infiltrates the salivary gland epithelium by binding to ACE2 receptors, causing local inflammation and cellular damage ( 14 ). Concurrently, the host's immune response, while attempting to combat the virus, may overshoot, releasing a deluge of cytokines in a detrimental ‘cytokine storm’, leading to further tissue inflammation and gland swelling ( 15 , 16 ). Compounding this, SARS-CoV-2 affects endothelial cells, causing dysfunction that manifests as increased vascular permeability and oedema, which is a condition conducive to parotitis ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review

Marino,

Cacciaguerra,

Spampinato

et al. 2024

Biomed Rep

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection usually affects the respiratory system; however, a number of atypical manifestations of this disease have also been reported, especially in children. The present study reports a case of a 12-year-old presenting with right unilateral parotitis and sialadenitis and SARS-CoV-2 infection. The young patient, after a 3-day history of fever, was brought to our clinic (Polyclinic University Hospital ‘G. Rodolico’, Catania, Italy) for the sudden onset of unilateral parotitis accompanied by sialadenitis and hyperaemia of the skin, which was tender to touch. The SARS-CoV-2 molecular swab was positive; the ultrasound of the affected region showed an increase in the volume of the parotid and sublingual gland and reactive lymph nodes compatible with parotitis and sialadenitis. This case suggests that, in the present Coronavirus disease 2019 pandemic, SARS-CoV-2 should be included in the differential diagnosis of parotitis and sialadenitis along with mumps and flue. Notably, a respiratory panel and serology for other potential causes are needed in case of parotitis-like disease.

show abstract

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review

Marino,

Cacciaguerra,

Spampinato

et al. 2024

Biomed Rep

View full text Add to dashboard Cite

show abstract

“…Patients with immunodeficiency, hypercoagulability, and pathological disorders that might cause chronic inflammation are more vulnerable to infection and an inflammatory state [ 116 ]. There is evidence that individuals with an early hyperinflammatory phenotype and organ damage in the second week following the beginning of symptoms may benefit primarily from inhibiting the IL-6 in terms of treating this sort of excessive inflammatory response in COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Hyperinflammatory Response in COVID-19: A Systematic Review

Silva

Ribeiro

Gouveia

et al. 2023

Viruses

View full text Add to dashboard Cite

COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory response that cause systemic inflammation are extremely linked to its severity. This research sought to review the immunopathological elements that contribute to its progression. This is a systematic review using the PUBMED, LILACS, MEDLINE, and SCIELO databases using articles between May 2020 and July 2022 with the following search terms in conjunction with “AND”: “SARS-CoV-2”; “COVID-19”; “ARDS” and “Cytokine Storm”. The quality appraisal and risk of bias were assessed by the JBI checklists and the Cochrane Collaboration’s RoB 2.0 and ROBINS-I tools, respectively, and the risk of bias for in vitro studies by a pre-defined standard in the literature. The search resulted in 39 articles. The main actors in this response denote SARS-CoV-2 Spike proteins, cellular proteases, leukocytes, cytokines, and proteolytic cascades. The “cytokine storm” itself brings several complications to the host through cytokines such as IL-6 and chemokines (such as CCL2), which influence tissue inflammation through apoptosis and pyroptosis. The hyperinflammatory response causes several unfavorable outcomes in patients, and systemic inflammation caused largely by the dysregulation of the immune response should be controlled for their recovery.

show abstract

“…Among bacterial and viral superinfections [ 22 , 23 , 24 ], COVID-19 has been widely associated with mucormycosis through several pathological patterns such as immune system impairment due to cytokine storm [ 25 ], impaired phagocytosis, and endothelitis [ 26 , 27 ]. In addition, immunosuppressive therapies such as corticosteroids and immunomodulatory therapies such as anti-IL6 antibodies favor the development of COVID-19 associated mucormycosis (CAM) [ 28 , 29 , 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination

et al. 2023

Self Cite

View full text Add to dashboard Cite

Hematological diseases, especially those causing severe neutropenia, represent the main factor in the development of invasive fungal infections (IFIs). Furthermore, COVID-19 has been considerably associated with IFIs due to immunological dysregulation, prolonged hospitalization in intensive care units, and immunomodulatory therapies. Opportunistic molds are correlated with elevated morbidity and mortality rates in these patients, due to immune impairment, diagnostic complexity, and therapeutic challenges. Among opportunistic fungal infections, the Mucorales and Fusarium species are considered particularly aggressive, especially during severe neutropenia. A mixed Mucorales/Fusarium infection has been rarely described in scientific literature. Herein, we report a case of Mucorales and Fusarium co-infection in a patient with acute leukemia whose clinical history was also complicated by COVID-19. Herein, we report a challenging case in order to encourage the clinical suspicion of combined fungal infections in immunosuppressed patients, performing a punctual microbiological diagnosis, and promptly administering the correct empiric and targeted antifungal therapy.

show abstract

Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review

Cited by 5 publications

References 29 publications

SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review

SARS-CoV-2 associated unilateral parotitis in children: A case report and literature review

Hyperinflammatory Response in COVID-19: A Systematic Review

Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination

Contact Info

Product

Resources

About