Pain control for laparoscopic hysterectomy with magnesium versus nalbuphine added to intraperitoneal bupivacaine: a randomized double-blinded study

Elbeialy, Marwa Ahmed Khairy; Mowafi, Marwa M.; Elsenity, Mohamed

doi:10.4103/roaic.roaic_50_18

Cited by 1 publication

(4 citation statements)

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“…According to Elbeialy et al regarding total diclofenac consumption per 24 h, it was significantly higher in BM group when compared with BN group. 32 Moreover, rescue analgesia time was significantly shorter in BM group when compared with BN group. Badawy et al noted a significant increase in the time required for 1st analgesia in bupivacaine and magnesium sulphate group than without instillation group, also the amount of analgesia needed was significantly less in study group than comparison group, and number of patients need for opioids in were more in group receiving no any intraperitoneal instillation than compared to patients receiving instillation of bupivacaine and magnesium sulphate.…”

Section: Discussionmentioning

confidence: 91%

“…Similar results were reported by Elbeialy et al for use of intraperitoneal bupivacaine with nalbuphine compared to magnessium postoperatively at 6 and 12 hours but it was opposite at 1, 2, 4, and 12 hours. 32 Badawy et al reported significantly lower VAS in Bupivacaine and Magnesium Sulphate group at 6, 12 and 24 hours after laparoscopy than a placebo group, while difference was insignificant after 7 days. 3 A significant reduction in pain intensity was noted in bupivacaine and magnesium sulphate group.…”

Section: Discussionmentioning

confidence: 96%

“…3 Intraperitoneal instillation of local anesthetics, with or without adjuncts, has become a popular way to manage postlaparoscopic pain. 32 The present study was aimed to compare the efficacy of intraperitoneal instillation of bupivacaine versus placebo for post-operative analgesia after laparoscopic hysterectomy. Among 2 groups with 25 patients in each group viz.…”

Section: Discussionmentioning

confidence: 99%

“…They also provide antinociception by affecting nerve membrane-associated proteins and inhibiting the release of prostaglandins that stimulate nociceptors and boost the inflammatory process. 32 Systemic absorption of local anesthetic from the peritoneal cavity may also play a part in reduced nociception although this would be expected to occur after any local anesthetic technique. Systemic levels of local anesthetic are detectable in the serum circulation as soon as 2 minutes after bolus instillation into the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Randomized control trial of intra-peritoneal instillation of bupivacaine versus placebo for post-operative analgesia after laparoscopic hysterectomy

Dudam

Barsode

Borse

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Laparoscopy is an established method to perform major surgeries, with many advantages over open surgeries. Hysterectomy is a common procedure performed with increased use of laparoscopy, having postoperative pain management is a major issue. Effective pain management promotes early ambulation, lowering the risk of DVT and PE.Methods: The present study aimed to assess effect of bupivacaine intraperitoneally during laparoscopic hysterectomy to reduce postoperative pain. 48 women undergoing laparoscopic hysterectomy under ASA I and II general anesthesia were included, divided into 2 groups, group A receiving 0.25% bupivacaine intraperitoneally; group B receiving saline. A blind observer observed both groups for 6 hours post-surgery or until the VAS was 4, whichever came first, need for rescue analgesia, side-effects, and total dose of analgesia required in 24 hours. Diclofenac sodium and paracetamol was used as rescue analgesia for both groups.Results: There was no significant difference reported in demographic parameters between two study groups. The VAS scores at 6, 12 and 24 hours after laparoscopy was significantly lower in group A than group B. There was significant increase in the time required for 1st analgesia, while amount of analgesia required was significantly low in group A as compared to group B. There were significantly more number of patients in group B who needed opioids than group A.Conclusions: Peritoneal bupivacaine instillation after laparoscopic hysterectomy was found to be useful to reduce the pain as compared to use of saline (placebo), significant reduction in need for analgesics in the postoperative period.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 96%