“…Through a hypothesized inhibitory effect of dexamethasone on nociceptive pain fibers, upregulation of inhibitory potassium channels, and a regional decrease in blood flow to slow the dissipation of an infiltrated anesthetic, the majority of published randomized control trials in the orthopedic, gynecologic, and general surgery literature have demonstrated promising outcomes associated with bupivacaine-dexamethasone mixtures relative to bupivacaine alone, through prolonged durations of analgesia and decreased opioid consumption. 7 A recent study by Taylor et al was the first in plastic surgery to report on use of bupivacaine-dexamethasone blocks, demonstrating significant reductions in postoperative pain in patients undergoing reduction mammaplasty receiving this formulation in pectoralis nerve blocks. 7 …”