Pain as Initial Presenting Symptom Is Associated With Delay to Seeking Medical Attention, Higher Risk of Relapse, and Shorter Survival in Patients With Early-Stage Extremity or Trunk Synovial Sarcoma

Seto, Tiffany; Morse, Lee Jae; Fang, Andrew; Song, Mee-Na; Russell, Elisabeth A.; Pan, Minggui

doi:10.7812/tpp/21.199

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Better OS for male versus female patients in metastatic colorectal, kidney, and bladder cancer was also found in a SEER database study ( 30 ). In a separate SEER database (between January 1975 and December 2016) study in patients with synovial sarcoma it was found that male patients had worse OS than female patients, ( 31 ) though in our previous synovial sarcoma cohort study we did not detect an obvious OS difference between male and female patients ( 32, 33 ). In another SEER database study on head and neck sarcoma, male patients were found to have higher risk of cause-specific death than female patients ( 34 ).…”

Section: Discussionmentioning

confidence: 65%

Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma

Pan,

Zhou,

Jiang

et al. 2023

Clinical Cancer Research

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Purpose: To examine whether overall survival (OS) differs for male and female patients with advanced soft tissue sarcoma (STS). Methods: The study included patients from Kaiser Permanente Northern California and Stanford Cancer Center with grade 2 and 3 locally advanced or metastatic STS whose tumor underwent next-generation sequencing. We used Cox regression modeling to examine association of sex and OS adjusting for other important factors. Results: Among 388 eligible patients, 174 had leiomyosarcoma (LMS), 136 had undifferentiated pleomorphic sarcoma (UPS), and 78 had LPS (Liposarcoma). OS for male versus female patients appeared to be slightly better among the full cohort (HR =0.89, [95% CI 0.66-1.20]); this association appeared to be stronger among the subsets of patients with LMS (HR = 0.76, [95% CI 0.39-1.49]) or LPS (HR = 0.74, [95% CI 0.32-1.70]). Better OS for male versus female patients was also observed among all molecular subgroups except mutRB1 and mutATRX, especially among patients whose tumor retained wtTP53 (HR = 0.73, [95% CI 0.44-1.18]), wtCDKN2A (HR = 0.85, [95% CI 0.59-1.23]), wtRB1 (HR = 0.73, [95% CI .51-1.04]) and among patients whose tumor had mutPTEN (HR = 0.37, [95% CI 0.09-1.62]). OS also appeared to be better for males in the MSK-IMPACT and TCGA datasets. Conclusions: A fairly consistent pattern of apparent better OS for males across histologic and molecular subgroups of STS was observed. If confirmed, our results could have implications for clinical practice for prognostic stratification and possibly treatment tailoring as well as for future clinical trials design.

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Section: Discussionmentioning

confidence: 65%

Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma

Pan,

Zhou,

Jiang

et al. 2023

Clinical Cancer Research

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Extradural Primary Malignant Spinal Tumors in a Population Younger than 25 Years: An Ambispective International Multicenter Study on Onco-Surgical Outcomes

Disch

Boriani

Luzzati

et al. 2023

Cancers

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Extradural malignant primary spinal tumors are rare and outcome data, especially for younger patients, is limited. In a worldwide (11 centers) study (Predictors of Mortality and Morbidity in the Surgical Management of Primary Tumors of the Spine study; ClinicalTrials.gov Identifier NCT01643174) by the AO Spine Knowledge Forum Tumor, patients surgically treated for primary tumors of the spine between 1992 and 2012, were retrospectively analyzed from a prospective database of their medical history. Medical history, tumor characteristics, diagnostics, treatments, cross-sectional survival, and local recurrences were analyzed. Sixty-eight cases (32 f; 36 m), at an average age of 18.6 ± 4.7 years at the time of diagnosis, were identified (median follow-up 2.9 years). The most common entities were Ewing’s sarcoma (42.6%). Of the patients, 28% had undergone previous spine tumor surgery in another center (84% with intralesional margins). Resection was considered “Enneking appropriate” (EA) in 47.8% of the cases. Of the patients, 77.9% underwent chemotherapy and 50% radiotherapy. A local recurrence occurred in 36.4%. Over a third of patients died within a 10-year follow-up period. Kaplan-Meier-analysis demonstrated statistically significant overall survival (p = 0.007) and local recurrence rates (p = 0.042) for tumors treated with EA surgery versus Enneking inappropriate surgery. Aggressive resection of extradural primary malignant spinal tumors combined with adjuvant therapy reveals low local recurrence rates and better outcomes overall in younger patients.

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Pain as Initial Presenting Symptom Is Associated With Delay to Seeking Medical Attention, Higher Risk of Relapse, and Shorter Survival in Patients With Early-Stage Extremity or Trunk Synovial Sarcoma

Cited by 2 publications

References 28 publications

Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma

Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma

Extradural Primary Malignant Spinal Tumors in a Population Younger than 25 Years: An Ambispective International Multicenter Study on Onco-Surgical Outcomes

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