Pain and gastrointestinal dysfunction are significant associations with psychiatric disorders in patients with Ehlers–Danlos syndrome and hypermobility spectrum disorders: a retrospective study

Wasim, Syed; Suddaby, Jessica S.; Parikh, Manasi; Leylachian, S; Ho, Bernice; Guerin, Andrea; So, Joyce

doi:10.1007/s00296-019-04293-w

Cited by 23 publications

(42 citation statements)

References 42 publications

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“…Subjects were also asked whether they were taking analgesics and neuromodulators, given that pain and psychological distress is commonly associated with HSD/hEDS. 3,19 2. Patient health questionnaire (PHQ)-9 and General anxiety disorder (GAD)-7 questionnaire-These are nine-and seven-item questionnaires, respectively, which are widely used and validated to assess severity of symptoms of depression and generalized anxiety.…”

Section: Key Pointsmentioning

confidence: 99%

“…With diagnosis based entirely on clinical evaluation, HSD and hEDS have historically been merged as indistinct conditions by patients and research groups, although recent data suggest that under the new classification system the vast proportion of subjects with HSD/hEDS are represented by HSD. 3 The majority of subjects with HSD/hEDS are young-to-middle aged women, 1,2 in whom co-morbidity commonly stems from gastrointestinal complaints, which are most often attributable to functional gastrointestinal disorders (FGIDs). 4 Between 60% to over 90% of individuals with HSD/hEDS fulfill criteria for a Rome IV FGID, 4,5 with widespread somatic symptom reporting and opiate use being important mediating factors for gut symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Functional gastrointestinal disorders are increased in joint hypermobility‐related disorders with concomitant postural orthostatic tachycardia syndrome

Tai

Palsson

Lam

et al. 2020

Neurogastroenterology Motil

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Section: Key Pointsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional gastrointestinal disorders are increased in joint hypermobility‐related disorders with concomitant postural orthostatic tachycardia syndrome

Tai

Palsson

Lam

et al. 2020

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…Delays in diagnosis and treatment of anxiety can lead to poorer social functioning, as well as pain catastrophizing and sensory amplification [3]. For example, patients with EDS who were found to be highly anxious scored significantly higher in pain catastrophizing and somatosensory amplification when compared to their non-anxious counterparts [1].…”

Section: Discussionmentioning

confidence: 99%

“…Some examples of these disorders include anxiety, depression, eating disorders, and neuro-developmental disorders [2]. In a systematic, retrospective chart review of 391 patients, 49.4% were reported to have a psychiatric disorder, with 28.9% having two or more disorders, and 26.6% having an anxiety disorder [3]. These patients often also suffer from chronic pain, which is associated with an increased incidence of comorbid psychiatric disorders [3].…”

Section: Introductionmentioning

confidence: 99%

“…In a systematic, retrospective chart review of 391 patients, 49.4% were reported to have a psychiatric disorder, with 28.9% having two or more disorders, and 26.6% having an anxiety disorder [3]. These patients often also suffer from chronic pain, which is associated with an increased incidence of comorbid psychiatric disorders [3]. For example, one study found that 29% of patients with chronic pain also suffer from depression [4].…”

Section: Introductionmentioning

confidence: 99%

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Risperidone for the Management of Treatment-Resistant Anxiety in a Patient with Ehlers-Danlos Syndrome: A Case Report

Niedt

Young

Sharoha

2020

Cureus

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Patients with Ehlers-Danlos syndrome (EDS) have a higher prevalence of comorbid anxiety disorders. Due to the complex nature of these patients, there is often a delay in the diagnosis of these disorders as well as insufficient management of their anxiety symptoms. Current treatment options are often insufficient or poorly tolerated by patients, creating barriers to proper treatment. We hypothesized that patients with EDS and comorbid anxiety, who have failed multiple medication trials, may benefit from a trial of risperidone. In this case report, we discuss the successful management of treatment-resistant anxiety in a patient with EDS with the use of risperidone. Management of comorbid anxiety in these patients is essential, as untreated anxiety can result in increased somatic sensation sensitivity and poor social functioning. Once underlying anxiety disorders are addressed, patients with EDS can better cope with chronic pain symptoms and are more likely to build a therapeutic alliance with their treating physicians. This results in an improved prognosis, social functioning, and overall quality of life.

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Heritable connective tissue disorders in childhood: Decreased health‐related quality of life and mental health

Warnink‐Kavelaars

Koning

Rombaut

et al. 2022

American J of Med Genetics Pt A

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The psychosocial consequences of growing up with Heritable Connective Tissue Disorders (HCTD) are largely unknown. We aimed to assess Health‐Related Quality of Life (HRQoL) and mental health of children and adolescents with HCTD. This observational multicenter study included 126 children, aged 4–18 years, with Marfan syndrome (MFS, n = 74), Loeys–Dietz syndrome (n = 8), molecular confirmed Ehlers–Danlos syndromes (n = 15), and hypermobile Ehlers–Danlos syndrome (hEDS, n = 29). HRQoL and mental health were assessed through the parent and child‐reported Child Health Questionnaires (CHQ‐PF50 and CHQ‐CF45, respectively) and the parent‐reported Strengths and Difficulties Questionnaire. Compared with a representative general population sample, parent‐reported HRQoL of the HCTD‐group showed significantly decreased Physical sum scores (p < 0.001, d = 0.9) and Psychosocial sum scores (p = 0.024, d = 0.2), indicating decreased HRQoL. Similar findings were obtained for child‐reported HRQoL. The parent‐reported mental health of the HCTD‐group showed significantly increased Total difficulties sum scores (p = 0.01, d = 0.3), indicating decreased mental health. While the male and female MFS‐ and hEDS‐subgroups both reported decreased HRQoL, only the hEDS‐subgroup reported decreased mental health. In conclusion, children and adolescents with HCTD report decreased HRQoL and mental health, with most adverse outcomes reported in children with hEDS and least in those with MFS. These findings call for systematic monitoring and tailored interventions.

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Pain and gastrointestinal dysfunction are significant associations with psychiatric disorders in patients with Ehlers–Danlos syndrome and hypermobility spectrum disorders: a retrospective study

Cited by 23 publications

References 42 publications

Functional gastrointestinal disorders are increased in joint hypermobility‐related disorders with concomitant postural orthostatic tachycardia syndrome

Functional gastrointestinal disorders are increased in joint hypermobility‐related disorders with concomitant postural orthostatic tachycardia syndrome

Risperidone for the Management of Treatment-Resistant Anxiety in a Patient with Ehlers-Danlos Syndrome: A Case Report

Heritable connective tissue disorders in childhood: Decreased health‐related quality of life and mental health

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