Pain and functional improvement effects of methylene blue injection on the soft tissue around fusion site after traumatic thoracolumbar fixation: A double-blind, randomized placebo-controlled study

Farrokhi, Majid Reza; Yazdanpanah, Hamed; Gholami, Mehrnaz; Farrokhi, Farnaz; Mesbahi, Amir Reza

doi:10.1016/j.clineuro.2016.08.018

Cited by 15 publications

(22 citation statements)

References 58 publications

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“…As shown in Fig. 1, 17 articles were included in our review and are summarized in Tables 1 and 2 for interventional [4,[10][11][12][13][14][15][16] and observational [6][7][8][9][17][18][19][20][21][22] studies, respectively. Only seven articles of the 17 (41.2%) were interventional studies, all of which were in the form of randomized controlled trials (RCTs).…”

Section: Resultsmentioning

confidence: 99%

“…Non-specific pain, disability, poor quality of life (QOL), and prolonged hospital stay are important determinants of postoperative patient satisfaction [6,7,13,16].…”

Section: Patient Satisfaction and Long-term Outcomesmentioning

confidence: 99%

“…Farrokhi et al [16] investigated pain and functional improvements with methylene blue (MB) injection on the soft tissue surrounding the fusion site following traumatic thoracolumbar fixation. Patients who underwent posterior pedicle screw fixation following thoracolumbar fractures received 1 mL of MB at a concentration of 0.5%.…”

Section: Patient Satisfaction and Long-term Outcomesmentioning

confidence: 99%

“…That indicated improved functional QOL. Although a few patients admitted using additional analgesic drugs, a single dose of MB injection was considered adequate to render the pain bearable following surgery, and QOL showed notable improvement [16]. Furthermore, Farrokhi et al [13] investigated the effects of postoperative MB injection on LBP and functional outcomes following lumbar open discectomy in 115 patients.…”

Section: Patient Satisfaction and Long-term Outcomesmentioning

confidence: 99%

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Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

et al. 2019

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Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs as a part of the medical management of diseases of the spine. Our review article describes a systematic method using the PubMed/Medline database with a specific set of keywords to identify such benefits and drawbacks based on 17 original relevant articles published between January 2000 and February 2018; this provides the community of spine surgeons with available cumulative evidence contained within two tables illustrating both observational (10 studies; three cross-sectional, three case-control, and four cohort studies) and interventional (seven randomized clinical trials) studies. While tricyclic antidepressants (e.g., amitriptyline) and duloxetine can be effective in the treatment of neuropathic pain caused by root compression, venlafaxine may be more appropriate for patients with spinal cord injury presenting with depression and/or nociceptive pain. Despite the potential associated consequences of a prolonged hospital stay, higher cost, and controversial reports regarding the lowering of bone mineral density in the elderly, antidepressants may improve patient satisfaction and quality of life following surgery, and reduce postoperative pain and risk of delirium. The preoperative treatment of preexisting psychiatric diseases, such as anxiety and depression, can improve outcomes for patients with spinal cord injury-related disabilities; however, a preoperative platelet function assay is advocated prior to major spine surgical procedures to protect against significant intraoperative blood loss, as serotonergic antidepressants (e.g., selective serotonin reuptake inhibitors) and bupropion can increase the likelihood of bleeding intraoperatively due to drug-induced platelet dysfunction. This comprehensive review of this evolving topic can assist spine surgeons in better understanding the benefits and risks of antidepressant drugs to optimize outcomes and avoid potential hazards in a spine surgical setting.

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Section: Resultsmentioning

confidence: 99%

“…Non-specific pain, disability, poor quality of life (QOL), and prolonged hospital stay are important determinants of postoperative patient satisfaction [6,7,13,16].…”

Section: Patient Satisfaction and Long-term Outcomesmentioning

confidence: 99%

Section: Patient Satisfaction and Long-term Outcomesmentioning

confidence: 99%

Section: Patient Satisfaction and Long-term Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

et al. 2019

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“…At each follow-up visit, a complete neurological examination was performed. The degree of sagittal and coronal angle correction was also measured [20][21][22][23]. The patients' LBP was assessed using Occupational Low Back Pain (OLBP) scale at each follow-up.…”

Section: Outcome Measurementsmentioning

confidence: 99%

Treatment of 44 Cases With Lumbar Spine Stenosis and Degenerative Instability: Outcomes of Surgical Intervention

Farrokhi

Yadollahikhales

Gholami

2017

IrJNS

Self Cite

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Background and Aim: Degenerative lumbar spine disease can lead to lumbar spine instability. The patients can present with Low Back Pain (LBP), radicular pain, and motor and sensory dysfunction. Age >50, female sex and pregnancies are among prevalent risk factors. The degeneration process usually starts from the intervertebral discs progressing to involve facet joints, ligaments, and vertebral bodies leading to spinal instability and deformity. This study aims to evaluate the effect of lumbar decompression and Posterolateral Fusion (PLF) on the short-and long-term outcomes of these patients. Methods and Materials/Patients:This prospective study assessed the effect of lumbar decompression and PLF in patients with lumbar instability referred to the Neurosurgery Clinic of Chamran hospital between March 2011 and March 2013. Forty-four patients with degenerative lumbar spine instability and stenosis were eligible for participation to undergo lumbar decompression and PLF. Its clinical effect was evaluated using Visual Analogue Scale (VAS) score and Oswestry Disability Index (ODI). The change in sagittal and coronal planes was also assessed according to pre-and post-operative findings at 2-year follow-up. The statistical method of assessment was repeated using paired t-test. P<0.05 was considered statistically significant. Results:The mean preoperative VAS score decreased significantly at 2 years after the surgery (6.87±1.07 vs. 2.20±1.15; P<0.001). The comparison between preoperative ODI and its 6-month, 1 and 2-year counterparts showed a significant improvement (P<0.001). Moreover, 82.7% of the patients showed a good fusion rate. The sagittal and coronal angles were reduced significantly after the surgery (P<0.05). Short vs. long segment fusion and inclusion of sacral body did not significantly affect the VAS, ODI scores and the deformity angles. Conclusion:Lumbar decompression and PLF is a safe and effective method for patients suffering from degenerative lumbar instability.

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Spinal sagittal balance and spinopelvic parameters in patients with degenerative lumbar spinal stenosis; a comparative study

Farrokhi

Haghnegahdar

Rezaee

et al. 2016

Clinical Neurology and Neurosurgery

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Pain and functional improvement effects of methylene blue injection on the soft tissue around fusion site after traumatic thoracolumbar fixation: A double-blind, randomized placebo-controlled study

Cited by 15 publications

References 58 publications

Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks

Treatment of 44 Cases With Lumbar Spine Stenosis and Degenerative Instability: Outcomes of Surgical Intervention

Spinal sagittal balance and spinopelvic parameters in patients with degenerative lumbar spinal stenosis; a comparative study

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