Pain Among Ambulatory HIV/AIDS Patients: Multicenter Study of Prevalence, Intensity, Associated Factors, and Effect

Namisango, Eve; Harding, Richard; Atuhaire, Leonard; Ddungu, Henry; Katabira, Elly; Muwanika, Fred Roland; Powell, Richard A.

doi:10.1016/j.jpain.2012.04.007

Cited by 46 publications

(40 citation statements)

References 56 publications

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“…18,19 Unlike Harding and colleagues, we did not find that female gender was correlated with symptom burden. 20 This difference may rest in the fact that we investigated correlates of pain only, while Harding and colleagues investigated correlates of physical burden as a whole, including but not limited to pain.…”

Section: Discussioncontrasting

confidence: 99%

“…[14][15][16][17] Research on the correlates of pain in SSA has found that in HIV patients, pain has been associated with increasing age, female gender, not being on antiretroviral therapy, number of symptoms, advanced disease, number of medical comorbidities, and reduced functional performance scores. [18][19][20] These studies are specific to ambulatory HIV/AIDS patients, and to date no research has been conducted to determine the burden of pain in a mixed inpatient hospital setting in SSA.…”

mentioning

confidence: 99%

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Prevalence and Correlates of Pain and Pain Treatment in a Western Kenya Referral Hospital

Huang

Owino

Gramelspacher

et al. 2013

Journal of Palliative Medicine

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Background: Pain is often inadequately evaluated and treated in sub-Saharan Africa (SSA). Objective: We sought to assess pain levels and pain treatment in 400 hospitalized patients at a national referral hospital in western Kenya, and to identify factors associated with pain and pain treatment. Design: Using face-validated Kiswahili versions of two single-item pain assessment tools, the Numerical Rating Scale (NRS) and the Faces Pain Scale-Revised (FPS-R), we determined patients' pain levels. Additional data collected included patient demographics, prescribed analgesics, and administered analgesics. We calculated mean pain ratings and pain management index (PMI) scores. Results: Averaged between the NRS and FPS-R, 80.5% of patients endorsed a nonzero level of pain and 30% of patients reported moderate to severe pain. Older patients, patients with HIV, and cancer patients had higher pain ratings. Sixty-six percent of patients had been prescribed analgesics at some point during their hospitalization, the majority of which were nonopioids. A majority of patients (66%) had undertreated pain (negative scores on the PMI). Conclusion: This study shows that hospitalized patients in Kenya are experiencing pain and that this pain is often undertreated.

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Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

Prevalence and Correlates of Pain and Pain Treatment in a Western Kenya Referral Hospital

Huang

Owino

Gramelspacher

et al. 2013

Journal of Palliative Medicine

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“…This ADR was very troublesome for HIV-infected patients. Our results confirm those of several authors on the frequency of neuropathies and risk factors during antiretroviral treatment [31,33,38,39]. This observation indicates that the ADR, however frequent and inconvenient, were supported by patients.…”

Section: Discussionsupporting

confidence: 92%

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Oumar¹,

Abdoulaye²,

Maiga³

et al. 2017

J Pharmacovigilance

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Objective: The purpose of this study was to evaluate the adverse effects of Antiretroviral Therapy (ART) in adult HIV-infected patients in decentralized setting of Sikasso, in Mali.Methods: This is a proactive study that took place from 2 January 2011 to 30 December 2012 at the Hospital of Sikasso (Department of Medicine). HIV-infected adult patients who have started ART at least 3 months before were included in this study to monitor the laboratory and clinical Adverse Drug Reactions (ADR) for at least 6 months. The WHO classification of adverse drug reactions has been used to investigate the causality of antiretrovirals.Results: Women were the most represented with 58% of the cases. The most represented age range was 26-47 years with 73.6%. Of the 178 patients enrolled, 61.2% had an ADR. ADR were neurological (40.4%), digestive (35.8%), cutaneous (18.3%) and hematological (5.5%). Stavudine was the most incriminated molecule, in 24.8% of the cases. The WHO grade 4 classification of ART toxicity was represented in 3.4% of the cases. The WHO causality score of "certain" was found in 29.8% of the cases. Conclusion:Adverse effects of Antiretrovirals are frequent and could be life-threatening in short and long terms. Regular follow-up of patients receiving these triple therapies, and the associated complications, is essential. We recommend active surveillance of antiretroviral therapy to strengthen Pharmacovigilance in Mali.

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“…Among patients with HIV, chronic pain is associated with worse quality of life [32, 33] and increased psychological distress [11, 34] as well as increased healthcare utilization [35] and among some, suboptimal adherence [36]. We are unaware of any prior studies that have examined associations between pain interference and mortality in people with HIV infection.…”

Section: Discussionmentioning

confidence: 99%

Pain and Mortality Risk in a Cohort of HIV-Infected Persons with Alcohol Use Disorders

et al. 2015

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Pain has been associated with increased risk for mortality in some studies. We analyzed data from a cohort study [HIV-longitudinal interrelationships of viruses and ethanol (HIV-LIVE)] of HIV-infected persons with alcohol use disorders enrolled 2001–2003 to explore whether reporting moderate or greater pain interference was associated with mortality. The main independent variable was pain that at least moderately interfered with work based on a single question from the SF-12. Primary analyses dichotomized at “moderately” or above. Cox proportional hazards models assessed the association between pain interference and death adjusting for demographics, substance use, CD4 count, HIV viral load and co-morbidities. Although significant in unadjusted models (HR = 1.58 (95 % CI 1.03–2.41; p value = 0.04)), after adjusting for confounders, ≥moderate pain interference was not associated with an increased risk of death [aHR = 1.30 (95 % CI 0.81–2.11, p value = 0.28)]. Among HIV-infected persons with alcohol use disorders, we did not detect a statistically significant independent association between pain interference and risk of death after adjustment for potential confounders.

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Pain Among Ambulatory HIV/AIDS Patients: Multicenter Study of Prevalence, Intensity, Associated Factors, and Effect

Cited by 46 publications

References 56 publications

Prevalence and Correlates of Pain and Pain Treatment in a Western Kenya Referral Hospital

Prevalence and Correlates of Pain and Pain Treatment in a Western Kenya Referral Hospital

Adverse Drug Reactions to Antiretroviral Therapy (ART): Prospective Study in HIV Infected Adults in Sikasso (Mali)

Pain and Mortality Risk in a Cohort of HIV-Infected Persons with Alcohol Use Disorders

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