Pain

Herr, Keela; Gibson, Stephen; Hadjistavropoulos, Thomas

doi:10.1002/9781118772034.ch28

Cited by 3 publications

(2 citation statements)

References 112 publications

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“…Because of these concerns, the principle of 3Rs (Replacement, Reduction and Refinement) must be followed before including animals into any testing procedure 2,3 . General consensus dictates to avoid using animal tests whenever reliable and consistent alternatives are available 4 . These efforts have been instigated also by legislative powers e.g.…”

Section: Introductionmentioning

confidence: 99%

Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Paštěka

Forjan

Sauermann

et al. 2019

Sci Rep

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Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10–18 bpm) and tidal volumes (400–600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation |3σ| for both, simplified lung equivalents ( = 23.98 ± 1.04 l/min, μP = −0.78 ± 0.63 hPa) and primed porcine lungs ( = 18.87 ± 2.49 l/min, μP = −21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.

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Section: Introductionmentioning

confidence: 99%

Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Paštěka

Forjan

Sauermann

et al. 2019

Sci Rep

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“…To aid in the assessment of pain in language‐impaired populations, observational tools were developed for the assessment of pain in AD using non‐verbal assessment. These tools require additional training and many necessitate further research to determine their reliability and validity (Herr et al., 2016 , 2018 , 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Treating the most vulnerable: A discursive review of experimental pain in Alzheimer’s disease

et al. 2021

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The purpose of this discursive manuscript is to review three distinct studies that used very similar research methods, allowing the results to be critically compared. Following a series of three fictional vignettes describing various clinical scenarios managing pain, we introduce the reader to the research method of pain psychophysics.Next, we discuss how the three research studies described compliment and contrast one another. The discursive review format offers nurses an overview of a research method seldom used by nursing scientists. Psychophysical experiments allow a unique opportunity to examine the neurobiology and psychology of the pain experience in people with dementia.

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Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and non-invasive approach for the management of opioid overdose

Hasan

Imran

Kesharwani

et al. 2021

International Journal of Pharmaceutics

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Pain

Cited by 3 publications

References 112 publications

Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Treating the most vulnerable: A discursive review of experimental pain in Alzheimer’s disease

Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and non-invasive approach for the management of opioid overdose

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