Pagetoid reticulosis (epitheliotropic cutaneous T-cell lymphoma) in an adult alpaca (<i>Vicugna pacos</i>)

Hasbach, Andrea E.; Stern, Adam W.

doi:10.1177/1040638716645833

Cited by 8 publications

(15 citation statements)

References 18 publications

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“…CEL has been widely reported in dogs and cats . However, reports of CEL in other species are rare and include cows, hamsters, mice, and single reports in a rat, ferret, squirrel, coati, cuscus, chipmunk, zebrafish, hedgehog, Tasmanian devil, opossum, marsh rice rat, and alpaca . There are currently no reports of CEL in NHPs.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous epitheliotropic lymphoma in a baboon (Papiospp.): A case report and a brief literature review

Carias

DeLorenzo

Owston

et al. 2019

J of Medical Primatology

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Cutaneous epitheliotropic lymphoma (CEL) is a rare neoplasm of T-cell lymphocytes with a tropism for epidermis and adnexal components. 1-4 CEL, or epidermotropic lymphoma, 5,6 was first reported in humans as a condition called mycosis fungoides (MF). 7 CEL is extremely rare in non-canid species 4 ; there have been no reports of CEL in non-human primates (NHPs). We present a case of CEL in a 9-year-old baboon and present a brief review of CEL in veterinary literature. | C A S E REP ORTThe 9-year-old female baboon (Papio spp.) was maintained at the Southwest National Primate Research Center and presented with raised pruritic lesions on the right forearm skin. The animal was treated with cephalexin (538.5 mg, PO BID, Lupin Pharmaceuticals) for 1 week. The lesion persisted, and following the results of a skin punch biopsy, the animal was euthanized 2 months later. All animal care and procedures were approved by the Texas Biomedical Research Institute Institutional Animal Care and Use Committee.A complete necropsy was performed; except for the skin and axillary lymph node (enlarged), the rest of the organs were AbstractCutaneous epitheliotropic lymphoma (CEL) has not been reported in non-human primates. We report the first case of CEL in a 9-year-old baboon. The phenotype of the neoplastic cells in this baboon is similar to CEL in humans (CD3+, CD4+, CD8−) and different from dogs (CD3+, CD4−, CD8+).

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Section: Discussionmentioning

confidence: 99%

Cutaneous epitheliotropic lymphoma in a baboon (Papiospp.): A case report and a brief literature review

Carias

DeLorenzo

Owston

et al. 2019

J of Medical Primatology

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“…The report by Valentine et al reports only 12.5% of all neoplastic cases being lymphoma (5 out of 40 cases), and it was the third most common tumor following fibromas/fibropapillomas/fibrosarcomas and squamous cell carcinomas (3). In the published cases, lymphoma generally presented widely disseminated with rare reports of cutaneous and solitary masses (5,43,59). Phenotyping by immunohistochemistry in 63 of these cases identified 24 B cell (38%), 28 T cell (44%), 1 mixed T and B cell, and 13 (20.6%) as non-B, non-T cell lymphoma (43,(48)(49)(50)(51)(52)(54)(55)(56)(57)(58)(59).…”

Section: Literature Casesmentioning

confidence: 99%

“…In the published cases, lymphoma generally presented widely disseminated with rare reports of cutaneous and solitary masses (5,43,59). Phenotyping by immunohistochemistry in 63 of these cases identified 24 B cell (38%), 28 T cell (44%), 1 mixed T and B cell, and 13 (20.6%) as non-B, non-T cell lymphoma (43,(48)(49)(50)(51)(52)(54)(55)(56)(57)(58)(59).…”

Section: Literature Casesmentioning

confidence: 99%

Neoplasia and Proliferative Lesions of New World Camelids: A Systematic Literature Review and Retrospective Study of Cases Submitted to Colorado State University From 1995 to 2020

et al. 2021

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Camelid pathology submissions to veterinary diagnostic laboratories are on the rise given the increasing popularity and population of llamas and alpacas especially in the western United States. When compared to other animals, the field of camelid neoplasia has a relative paucity of cases reported in the literature. The Colorado State University Veterinary Diagnostic Laboratories (CSU-VDL) has had a steady increase in the numbers of camelid pathology submissions allowing for a robust review of diagnoses of neoplasia in new world camelids. Here we present a retrospective analysis of camelid neoplastic and proliferative lesions diagnosed at the CSU-VDL from 1995 to 2020, followed by an extensive literature review. Results show increasing incidence of camelid neoplasia reported in the literature, therefore becoming a common diagnosis in llamas and alpacas. Proliferative and neoplastic lesions were diagnosed in 8.8% of new world camelid submissions to CSU-VDL with the most common tumors being lymphomas, squamous cell carcinomas, fibromas, and adenocarcinomas. Risk factors are female sex and increased age except in the case of lymphoma, which tends to occur in younger camelids. Lymphomas, melanomas, and adenocarcinomas (especially of gastrointestinal tract) carry an increased risk of multiple-organ system involvement often with widespread metastases. Conditions described in camelids for the first time include osteosarcoma, cutaneous hemangiosarcoma, myxosarcoma, pilomatricoma, ovarian theca cell tumor, congenital nevus with malignant transformation, and various other neoplasia. This article will provide an operational guide for camelid neoplasia to further assist veterinary laboratory diagnosticians, researchers, and practicing veterinarians in the field of camelid medicine and pathology.

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“…In South American camelids (SAC) neoplasms are commonly seen [ 1 – 6 ]. The most frequently reported type of neoplasias are lymphomas.…”

Section: Introductionmentioning

confidence: 99%

T-cell-lymphoma presented as a solitary subcutaneous mass in the ventral cervical region of an adult llama- diagnostic and treatment

et al. 2022

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Background Neoplasm in South American camelids (SAC) are commonly described. The most frequently reported type of neoplasm are lymphomas and difference in the age suffering from lymphomas of and llamas is seen. This report describes a case of a solitary lymphoma in a 5 years and 9 month old llama mare displaying the approach of diagnostic imaging and successful surgical treatment. Case presentation The llama was referred to the clinic for dyspnoea and inspiratory abnormal respiratory sounds. The clinical examination comprised blood cell count, ultrasonographic and radiographic examinations, endoscopy and fine needle aspiration cytology of a mass detected in the mid cervical region. The mass was surgically removed. Histopathological examination of the surgically removed mass diagnosed a malignant T-cell- lymphoma. According to the results of the clinical, ultrasonographic and radiographic examinations no tumor invasion was apparent in distant organs and the llama was discharged from the clinic seven days after surgery. Conclusion Lymphoma has been reported to be the most common neoplasia in camelids and are more often described in young alpacas and in adult llamas. To the author´s knowledge the case presented here is the first that described a broad panel of diagnostic tools including ultrasound, radiographs, endoscopy, fine needle aspiration cytology and histopathoogical examination as well as a successful surgical treatment of a solitary lymphoma in camelids.

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Pagetoid reticulosis (epitheliotropic cutaneous T-cell lymphoma) in an adult alpaca (Vicugna pacos)

Cited by 8 publications

References 18 publications

Cutaneous epitheliotropic lymphoma in a baboon (Papiospp.): A case report and a brief literature review

Cutaneous epitheliotropic lymphoma in a baboon (Papiospp.): A case report and a brief literature review

Neoplasia and Proliferative Lesions of New World Camelids: A Systematic Literature Review and Retrospective Study of Cases Submitted to Colorado State University From 1995 to 2020

T-cell-lymphoma presented as a solitary subcutaneous mass in the ventral cervical region of an adult llama- diagnostic and treatment

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