Pagetoid dyskeratosis of the prepuce. An incidental histologic finding resembling extramammary Paget's disease

Abstract

The pathologist should be familiar with the histologic features of pagetoid dyskeratosis in the foreskin in order to avoid misdiagnosis and unnecessary treatment. Routine histologic study is usually sufficient to identify the lesion.

Two Case Reports of Columnar Dyskeratosis, an Unusual Keratinisation Disorder

“…In PD, dyskeratotic cells are individually dispersed in the stratum spinosum, not arranged in columns, and are absent in the stratum corneum [7]. They also show strikingly pyknotic nuclei, unlike in our patients, where pyknosis is less expressed.…”

Comparative Study of Pagetoid Dyskeratosis Between Acrochordons and Soft Fibromas

“…For EMA and low weight cytokeratin, the reaction is similar to the surrounding keratinocytes. 1 All these findings allow PD to be distinguished from other entities with epidermal pale cells such as mammary Paget's disease, 9 primary extrammamary Paget's disease, 10 secondary extrammamary Paget's disease, warts (koilocytes), 4 clear cell Bowen's disease, 5 pagetoid melanoma, clear cell papulosis, 9 Toker's cells of the nipple, 11 or artifacts. Table 2 shows some of the differences among these types of clear cells.…”

“…Since then, only the Val-Bernal group has studied this condition. [3][4][5][6] They demonstrated its high prevalence on the foreskin of patients treated for phimosis (37.4% of cases), 3 on the lips of patients treated for other conditions, 4 on the cervix in uterine prolapse, 5 or in hemorrhoidal disease. 6 Currently, PD is considered an incidental finding, 1 however; it seems to be the unique pathological finding in some cases of patchy discoloration of the dorsal aspect of the hand.…”

Pagetoid dyskeratosis of the forehead

“…who have described it in various locations, such as lips,[2] nipple,[4] prepuce,[5] hemorrhoids,[6] and cervix of the prolapsed uterus. [7] Lee et al .…”